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39/100

✓ Peer-reviewed alzhub usefulness score 39 out of 100. Risk factors

Topic: Brain proteins, microglia and lab models

Environmental factors like neighborhood disadvantage are also associated with cognitive decline, however, few studies have integrated this with APOE research. Result CFA results supported the domain groupings (Χ 2 (34)=95.395, p < .001; RMSEA = 0.080 [90% CI=0.062, 0.100]; CFI = 0.952; TLI = 0.922). Only memory and attention domains met normality assumptions and neither the overall model for memory ( R 2 = 0.17, F (10, 75)=1.48, p = .163) or attention ( R 2 = 0.16, F (10, 75)=1.40, p = .199) were statically significant. APOE status was not a significant predictor for performance on memory ( β = ‐0.36, p = .430) or attention ( β = 0.52, p = .265) measures. ADI was not a significant predictor for performance on memory ( β = 0.15, p = .593) or attention (β=0.24, p = .414) measures. The APOE*ADI interaction was not significant for measures of memory ( β = ‐0.12, p = .486) or attention ( β = ‐0.14, p = .429).

Key findings

Environmental factors like neighborhood disadvantage are also associated with cognitive decline, however, few studies have integrated this with APOE research.
Result CFA results supported the domain groupings (Χ 2 (34)=95.395, p < .001; RMSEA = 0.080 [90% CI=0.062, 0.100]; CFI = 0.952; TLI = 0.922).
Only memory and attention domains met normality assumptions and neither the overall model for memory ( R 2 = 0.17, F (10, 75)=1.48, p = .163) or attention ( R 2 = 0.16, F (10, 75)=1.40, p = .199) were statically significant.
APOE status was not a significant predictor for performance on memory ( β = ‐0.36, p = .430) or attention ( β = 0.52, p = .265) measures.
ADI was not a significant predictor for performance on memory ( β = 0.15, p = .593) or attention (β=0.24, p = .414) measures.

Why it matters

In this study, neither APOE status, neighborhood disadvantage, nor their interaction significantly predicted memory or attention performance. The overall models were not statistically significant, so the study found no evidence that neighborhood disadvantage changes the relationship between APOE and cognition.

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Study details

Participants190
Effect size53.7%; 80.5%; 62.6%
Evidence strengthLow

How this study scored 39/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	190 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 3 year(s) since 2025
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Carmen I. Carrión: h-index 7 (OpenAlex, whole career)
Institution's track record	2 / 3	Yale University: institution h-index 1,927 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41448718)
Free to read	2 / 2	Free to read
Total	39 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

APA 7th

Wadia, L., Garriga, S. M., Belliveau, T., Arias, F., & Carrión, C. I. (2025). Does Neighborhood Disadvantage Moderate the Relationship between Apolipoprotein E Status and Cognitive Functioning? Alzheimer s & Dementia. https://doi.org/10.1002/alz70857_103936

Vancouver

Wadia L, Garriga SM, Belliveau T, Arias F, Carrión CI. Does Neighborhood Disadvantage Moderate the Relationship between Apolipoprotein E Status and Cognitive Functioning? Alzheimer s & Dementia. 2025. doi:10.1002/alz70857_103936. PMID: 41448718.

BibTeX

@article{wadia2025-41448718,
  author  = {Wadia, Lyla and Garriga, Stella M. and Belliveau, Timothy and Arias, Franchesca and Carrión, Carmen I.},
  title   = {{Does Neighborhood Disadvantage Moderate the Relationship between Apolipoprotein E Status and Cognitive Functioning?}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70857_103936},
  pmid    = {41448718},
  url     = {https://doi.org/10.1002/alz70857_103936}
}

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