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50/100

✓ Peer-reviewed alzhub usefulness score 50 out of 100. Risk factors

Topic: Brain proteins, microglia and lab models

A significant ADI × dementia interaction was observed for global atrophy (p = .005) and several other outcomes. Among participants in the 30% most disadvantaged group, dementia was associated with greater brain volume differences compared to no dementia (Table 2). Dementia was linked to greater global atrophy (Δ = +0.0502, 95% CI [0.0276, 0.0727]), lower total brain volume (Δ = -0.0435), middle temporal gyrus (Δ = -0.0009), and frontal pole (Δ = -0.0028), all p < .0001. A marginal trend was observed for parahippocampal volume (p = .074); no difference was found for hippocampus. Dementia was associated with greater global atrophy and lower brain volumes among disadvantaged individuals. These findings suggest that socioeconomic disadvantage may amplify dementia-related brain changes. The small number of participants with both dementia and high disadvantage (n = 14) is a limitation, underscoring the need for greater socioeconomic representation in future studies.

Key findings

A significant ADI × dementia interaction was observed for global atrophy (p = .005) and several other outcomes.
Among participants in the 30% most disadvantaged group, dementia was associated with greater brain volume differences compared to no dementia (Table 2).
Dementia was linked to greater global atrophy (Δ = +0.0502, 95% CI [0.0276, 0.0727]), lower total brain volume (Δ = -0.0435), middle temporal gyrus (Δ = -0.0009), and frontal pole (Δ = -0.0028), all p < .0001.
A marginal trend was observed for parahippocampal volume (p = .074); no difference was found for hippocampus.
Dementia was associated with greater global atrophy and lower brain volumes among disadvantaged individuals.

Why it matters

This brain bank study found that people with dementia living in the most disadvantaged neighborhoods had greater brain shrinkage than those without dementia. It suggests socioeconomic disadvantage may worsen dementia-related brain changes, but it does not test any treatment or prevention.

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Study details

Study designlongitudinal study
Participants14
Evidence strengthModerate

How this study scored 50/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	14 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 3 year(s) since 2025
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Barbara B. Bendlin: h-index 64 (OpenAlex, whole career)
Institution's track record	3 / 3	Stanford University: institution h-index 2,684 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 20 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41434365)
Free to read	2 / 2	Free to read
Total	50 / 100	—

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Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Hammond, A., Navaratna, R., Moody, J. F., DeWitt, A., Alosco, M. L., Atri, A., et al. (2025). Association of Neighborhood‐Level Disadvantage with Antemortem MRI Brain Volumes in a Multi‐site Brain Bank Donor Cohort. Alzheimer s & Dementia. https://doi.org/10.1002/alz70861_108929

Vancouver

Hammond A, Navaratna R, Moody JF, DeWitt A, Alosco ML, Atri A, et al. Association of Neighborhood‐Level Disadvantage with Antemortem MRI Brain Volumes in a Multi‐site Brain Bank Donor Cohort. Alzheimer s & Dementia. 2025. doi:10.1002/alz70861_108929. PMID: 41434365.

BibTeX

@article{hammond2025-41434365,
  author  = {Hammond, Angel and Navaratna, Ruvini and Moody, Jason F. and DeWitt, Amanda and Alosco, Michael Louis and Atri, Alireza and Bakulski, Kelly M. and Beach, Thomas G. and others},
  title   = {{Association of Neighborhood‐Level Disadvantage with Antemortem MRI Brain Volumes in a Multi‐site Brain Bank Donor Cohort}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70861_108929},
  pmid    = {41434365},
  url     = {https://doi.org/10.1002/alz70861_108929}
}

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