Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Download bibliography of all 8,032 studies, highest score first: BibTeX (.bib) · RIS (.ris)
Highest usefulness score first. Studies without a score come last.
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Receipt of potentially burdensome hospitalizations and treatments; receipt of postdischarge home and facility care.
Why it matters
This study found that Medicare Advantage enrollees were less likely to receive potentially burdensome treatments and less likely to die in a hospital than traditional Medicare enrollees, but when hospitalized they were more likely to die in the hospital and less likely to be transferred to rehabilitative or skilled nursing facilities. Greater use of home-based care may improve quality of care but may also leave patients without adequate assistance after hospitalization.
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Maintaining driving independence is important for older adults.
Why it matters
This study found that older adults with incident cognitive impairment used fewer distinct routes to their most common destination compared to cognitively normal adults. It suggests that driving patterns might be used as a digital biomarker for early detection, but it does not address treatment, cure, or prevention.
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TBI had the highest percentage (37%) compared to other conditions, which may be attributed to the prevalent challenge of cognitive impairment in TBI in addition to physical disability.
Why it matters
This study found that delayed discharges from rehabilitation are caused by medical complications, organizational issues, and family-related factors, with traumatic brain injury having the highest percentage. Such delays can lead to poorer health outcomes, reduced quality of life, and increased healthcare costs.
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Large pre-trained models, also known as foundation models (FMs), are trained in a task-agnostic manner on large-scale data and can be adapted to a wide range of downstream tasks by fine-tuning, few-shot, or even zero-shot learning.
Why it matters
This vision paper tested existing foundation models on geospatial tasks, including US state-level and county-level dementia time series forecasting, where large language models outperformed task-specific models in zero-shot or few-shot settings. It is a methods paper about geospatial artificial intelligence and does not address treating, curing, or preventing Alzheimer's disease.
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48/100
This study projects that the total cost of caring for Americans with Alzheimer's and related dementias will grow enormously over the coming decades, driven by an aging population.
Why it matters
This modelling study projects that the total cost of caring for Americans with Alzheimer's and related dementias will grow enormously over the coming decades, driven by an aging population. It underscores how much of the true cost of dementia care is currently invisible because it is provided for free by family members.
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A communication and relationship-centered definitional framework of ACP in dementia evolved through international consensus supporting inclusiveness of persons with dementia and their family.
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We are conducting a single-blinded, National Institutes of Health stage-2, randomized clinical trial to establish the efficacy of AB versus a time-matched and dose-matched education control (Health Enhancement Program [HEP]) in improving self-reported and objective outcomes of physical, cognitive, and emotional functions in 260 participants.
Why it matters
This is a protocol describing an ongoing trial of a remote program for older adults with chronic pain and early cognitive decline, and only recruitment information is reported. No results on treating, curing or preventing Alzheimer's disease are available yet.
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We will use results from this study to develop the first live video telehealth dyadic resiliency intervention focused on the prevention of chronic emotional distress in couples shortly after ADRD diagnoses.
Why it matters
This is a protocol for a study to develop a live video intervention aimed at preventing chronic emotional distress in couples after a dementia diagnosis. No results are reported, and it concerns emotional distress rather than treating, curing or preventing Alzheimer's disease.
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A higher degree of neighborhood disadvantage may contribute to the excess risk of MCI or dementia found among AA.
Why it matters
In two cohort studies in a disadvantaged Rust Belt community, African Americans had a higher proportion of mild cognitive impairment or dementia than European Americans and higher neighborhood disadvantage. The study used weighting to examine whether neighborhood disadvantage independent of individual socioeconomic status contributes to this difference.
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For automatic EEG diagnosis, this paper presents a new EEG data set with well-organized clinical annotations called Chung-Ang University Hospital EEG (CAUEEG), which has event history, patient's age, and corresponding diagnosis labels.
Why it matters
A deep learning model analyzing EEG data classified normal, mild cognitive impairment and dementia with an ROC-AUC of 0.9, and normal versus abnormal with 0.86. This supports automatic screening for early diagnosis, but it does not provide a treatment, cure or prevention.
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Many studies have examined factors associated with individuals of high or low healthcare spending in a given year.
Why it matters
This study used national survey data to track how Medicare beneficiaries move between low, medium, and high healthcare spending categories over three years. It is about spending patterns, not about treating, curing, or preventing Alzheimer's disease.
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Process evaluations confirmed satisfaction and high completion rates of the program.
Why it matters
In this randomized trial of 150 store workers in Japan, a dementia-friendly mobile microlearning program significantly improved attitude and knowledge after one month compared with controls, and all outcomes remained significantly improved after four months. Helping behavior increased in the intervention group but did not differ significantly between the groups, so the training may reduce stigma and increase helping behavior in stores.
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After adjusting for sex, years of education, smoking status, diabetes, hypertension, apolipoprotein E ε4 carriership, and hearing rehabilitation (defined as hearing aid or cochlear implant use), neither PTA (hazard ratio [HR] per 10-decibels hearing level increase of 0·99 (95% CI 0·89-1·12; p=0·91) nor WRS (HR per 10% decrease of 0·98, 95% CI 0·89-1 ·07; p=0·65) was significantly associated with the development of dementia.
Why it matters
In this population-based study, objective audiometric measures of hearing loss were not significantly associated with developing dementia, though they were linked to worse cognitive test performance over time. Subjective hearing difficulties reported by a study partner were associated with dementia, but this does not show that treating hearing loss prevents dementia.
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Dementia is a leading global cause of morbidity and mortality.
Why it matters
This review of economic studies found that community and population interventions targeting risk factors like smoking, education, and physical inactivity were highly cost-effective or cost-saving. This supports prevention strategies at a population level, but it is a review of costs, not a test of whether these interventions actually prevent dementia.
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The model accurately identified dementia subtypes using measures readily available in underrepresented settings, with a similar performance than advanced biomarkers.
Why it matters
This study developed a machine learning model combining demographic, neuropsychological, MRI, and connectivity data to distinguish behavioral variant frontotemporal dementia from Alzheimer's disease and healthy controls. It is about diagnosis in underrepresented settings, not about treating or curing Alzheimer's disease.
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Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer's Disease (AD).
Why it matters
This study looked at sex differences in how the hippocampus connects to other brain regions in people with mild cognitive impairment. It is about understanding why females may be more affected, and does not test any treatment, cure, or prevention.
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A comprehensive outcome monitoring system to monitor the quality and safety of care and variation for HCP recipients was developed.
Why it matters
This cross-sectional study developed quality and safety indicators for older Australians receiving government-funded home care packages. It is about monitoring home care, not about treating, curing or preventing Alzheimer's disease.
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The national prevalence of stunting was 36.81% (95% CI, 35.48%-38.15%), with significant spatial variations across Ethiopia.
Why it matters
This study is about stunting in children under 5 in Ethiopia and does not address Alzheimer's disease, dementia, or any related treatment, cure, or prevention.
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A consequence of our progressively ageing global population is the increasing prevalence of worldwide age-related cognitive decline and dementia.
Why it matters
This review suggests the microbiota-gut-brain axis may contribute to cognitive health and disease, but states the exact mechanisms remain undefined. It reports no treatment, cure, or prevention for Alzheimer's disease.
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This study describes the philosophy of expert practice and outlines a set of best practice principles when working with people with PPA.Implications for rehabilitationPrimary progressive aphasia (PPA) describes a group of language led dementias which deteriorate inexorably over time.
Why it matters
This consensus report describes the philosophy and practical approaches that speech and language therapists use when working with people who have primary progressive aphasia. It offers guidance on care delivery and does not report any treatment that cures, prevents, or modifies Alzheimer's disease.
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A growing body of research has shown that people with dementia are using digital technologies to enhance lived experience.
Why it matters
People with mild-to-moderate dementia used digital technologies during the COVID-19 pandemic to reduce isolation, access support and support well-being, though they also reported cognitive fatigue and usability problems. This is about supporting daily life and well-being, not about treating, curing or preventing dementia.
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Hysterectomy is often recommended for gynaecological symptomatology because menstruation inevitably ceases, and the mortality rate associated with this operation is low3.
Why it matters
This paper discusses hysterectomy for abnormal uterine bleeding, noting that the levonorgestrel-releasing intrauterine system was more effective than cyclical norethisterone with better compliance. It also notes that in Australia hysterectomy was over-represented in regional compared to metropolitan areas where limited access to primary health services reduced access to conservative treatments.
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Additionally, it is unknown whether the benefits of this cap would vary between Medicare patients with type 1 versus type 2 diabetes.
Why it matters
This study estimated how many Medicare patients with diabetes would benefit from a $35 monthly cap on insulin cost sharing and how much they would save. It provides no information on treating, curing or preventing Alzheimer's disease.
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Why it matters
No key findings were provided for this study, so no conclusions about treating, curing, or preventing Alzheimer's disease can be drawn from it.
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Our analysis included 12 364 adults aged 55-73 years from the UK Biobank cohort.
Why it matters
This UK Biobank analysis of 12,364 adults examined whether eye and systemic conditions are linked to incident dementia over follow-up. It is an observational study, so it cannot show that treating these conditions prevents dementia.
From across this topic
10 of the 7,981 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Does the High Prevalence of Vitamin D Deficiency in African Americans Contribute to Health Disparities?
- Sleep Duration and Sleep Quality in Caregivers of Patients With Dementia: A Systematic Review and Meta-analysis
- Changes to Medicare Advantage Risk Adjustment and Dementia Diagnosis in Older Adults
- Vitamin D and risk of cognitive decline in elderly persons
- Diagnostic Accuracy of FDG‐PET‐CT in Dementia: Assessing False Negatives in Clinical Practice
- Retinal vascular caliber and risk of dementia: the Rotterdam study
- The CES-D Scale
- Cognitive performance classification of older patients using machine learning and electronic medical records
- Age-related immune alterations and cerebrovascular inflammation
- Deep Learning-Based Framework for Predicting Mild Cognitive Impairment Progression in Neurology Using Longitudinal MRI