Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Concurrent diarrhea and wasting (DW) among children aged 6–24 months represents a critical public health threat in East Africa, exacerbating infection susceptibility, stunting, cognitive impairment, and mortality.
Why it matters
This study is about diarrhea and wasting in young children in East Africa and does not address treating, curing, or preventing Alzheimer's disease. It reports no findings on Alzheimer's disease.
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SCD participants were older, had fewer years of education, more depressive symptoms, and more subjective cognitive complaints than CU participants.
Why it matters
This study found that baseline free recall measures could identify people without objective cognitive impairment who later declined, and that poorer recall of middle position items specifically differentiated those with subjective cognitive decline who progressed to MCI from those who remained stable. The findings relate to prediction of progression, not treatment or prevention.
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Each 10% increase in UPF intake was associated with lower attention scores (-0.05 points) and higher dementia risk (+0.24 points), independent of Mediterranean diet adherence.
Why it matters
This cross-sectional study found that each 10% increase in ultra-processed food intake was associated with lower attention scores and higher dementia risk scores. It shows associations only and cannot prove that reducing ultra-processed food prevents dementia.
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Family caregivers had information, psychosocial, and self-care needs that were deeply intertwined and frequently coexisted at the same time.
Why it matters
Family caregivers of people with late-stage dementia reported overlapping needs for information, emotional support and self-care, and nursing home placement did not remove the burden of caregiving. The authors say these findings should lead to practical actions, such as mapping community resources, rather than just listing needs.
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= 0.049, respectively), followed by musculoskeletal pain in the back and lower limbs.
Why it matters
This cross-sectional study found that caregiver mental health was a key determinant of perceived burden of caring for people with dementia and cerebral palsy, exerting a stronger influence than patient dependence or physical demands, while patient-related variables such as functional dependence or disability were not directly associated with burden. It recommends integrating psychological screening and mental health support, but does not test any treatment, cure or prevention for Alzheimer's disease.
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There are well-documented racial disparities in the provision of end-of-life care and advance care planning (ACP).
Why it matters
This analysis of hospital records found that an apparent racial disparity in receiving advance care planning services did not persist after adjusting for age, sex, insurance and medical conditions. It concerns equity in end-of-life care delivery, not treating, curing or preventing Alzheimer's disease.
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Identity-by-descent (IBD) mapping provides complementary signals to genome-wide association studies (GWASs) when multiple causal haplotypes or variants are present but not directly tested.
Why it matters
This methods paper describes a new identity-by-descent mapping approach for finding Alzheimer's disease risk loci and identified six genome-wide significant signals in African, European, and Amish samples. It is a statistical genetics method and does not test or propose a treatment, cure, or prevention.
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We developed a serum Raman spectroscopy-based ensemble learning approach for graded cognitive screening.
Why it matters
This study developed a serum Raman spectroscopy-based ensemble learning model for graded cognitive screening with high area under the curve. It is a screening approach, not a treatment, cure, or prevention.
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Eighteen studies identified four core components of multidomain interventions: physical exercise, cognitive training, nutrition, and cardiovascular risk management.
Why it matters
This review of 18 studies found that multidomain interventions combining exercise, cognitive training, nutrition, and cardiovascular risk management were linked to cognitive improvement, better quality of life, and reduced dementia risk, though results were inconsistent. Key barriers included low adherence, resource limits, and cultural differences, so more research is needed to optimize these programs.
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BackgroundCholinesterase inhibitors (ChEIs) are cornerstones of the symptomatic treatment of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) and are also prescribed for vascular dementia (VaD).
Why it matters
This study of prescribing patterns found that among patients with dementia, those with vascular dementia had lower rates of cholinesterase inhibitors relative to Alzheimer's disease, and females and patients from ethnoracially minoritized populations also had lower rates. It shows disparities in who receives these symptomatic treatments.
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Broad barriers identified in the outer setting of the implementation framework include sociocultural values and a lack of supportive policies, guidelines, and financing.
Why it matters
This review identifies barriers to end-of-life care with dementia in Asian countries, including low dementia literacy and limited uptake of advance care planning, alongside facilitators such as community norms around caring for older adults at home. It proposes a research agenda prioritizing partnership with individuals with dementia and their caregivers.
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After screening, a total of 48 studies were included in this review.
Why it matters
This scoping review of 48 studies found wide variation in where people with dementia die, with long-term care facilities more common in Europe and North America and medical facilities more common in East Asia and the Pacific. It concerns place of death, not treating, curing or preventing Alzheimer's disease.
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Denmark is experiencing unprecedented population ageing, highlighting the importance of understanding age-related diseases, including dementia.
Why it matters
This age-period-cohort analysis found that younger cohorts in Denmark showed lower dementia incidence rates compared to older cohorts at similar ages, likely due to changes in modifiable risk factors. It also noted that dementia diagnoses increased with age and that incidence rates began to rise in 1997 when the first dementia-related drugs became available, followed by a decrease in later years.
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The development of non-pharmacological treatment approaches is supported by evidence that addressing key modifiable risk factors may prevent or delay up to 45% of dementia cases.
Why it matters
This describes the design of a multidomain lifestyle program for mild cognitive impairment, built with patients, families, clinicians, researchers and industry professionals. The authors contend it can contribute to the evidence base for such programs and help people with mild cognitive impairment manage their condition, but no treatment results are reported.
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System affiliation is associated with less restrictive PA policies in MA, highlighting organizational structure as an important dimension of utilization management.
Why it matters
This analysis found that Medicare Advantage plans affiliated with health systems required prior authorization for fewer service categories than unaffiliated plans. It contains no research findings on treating, curing, or preventing Alzheimer's disease.
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Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology.
Why it matters
This consensus statement from the International Working Group characterizes clinical profiles and nomenclature for frontotemporal dementia with right temporal predominance to enhance diagnostic precision. It aims to improve diagnosis and future therapeutic interventions but does not offer a treatment or cure.
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40/100
Top-tertile counties averaged 1986 dementia cases per 100,000 residents; 43.8% were in the South.
Why it matters
This study found that county-level dementia diagnosis prevalence across the United States varied widely and could be predicted with high accuracy using a small set of regionally adaptable variables, including higher diabetes prevalence, uninsured rate and fast-food access. The authors note that some predictors likely act as proxies and that collinearity limits causality, so these are associations rather than proven causes.
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Claims-based dementia algorithms have not been evaluated in the Medicare Advantage (MA) population, a critical gap given the rapid growth of MA and concerns about data completeness.
Why it matters
This study tested two claims-based dementia algorithms against a gold-standard classification in Medicare Advantage and fee-for-service populations. It found the algorithms had high specificity but lower sensitivity in Medicare Advantage in some years, which matters for identifying dementia cases but does not address treating or curing the disease.
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40/100
We found a significant increase in the likelihood of AWV uptake among telehealth adopters by 10.2 percentage points (p <0.001) than non-adopters of telehealth in traditional FFS Medicare plans.
Why it matters
This study found that telehealth adopters in traditional Medicare were more likely to use Annual Wellness Visits, which may support cognitive screening and earlier detection of mild cognitive impairment and related dementias. It addresses detection and care planning, not treating, curing, or preventing Alzheimer's disease.
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40/100
We found a significant increase in the likelihood of AWV uptake among telehealth adopters by 10.2 percentage points (p <0.001) than non-adopters of telehealth in traditional FFS Medicare plans.
Why it matters
This study found that telehealth adopters in traditional Medicare were more likely to use Annual Wellness Visits, which may support cognitive screening and earlier detection of mild cognitive impairment and related dementias. It addresses detection and care planning, not treating, curing, or preventing Alzheimer's disease.
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We used multilevel logistic regression with a random site intercept to test whether the probability of change in management associated with social determinants, race/ADI interactions with amyloid‐positivity, comorbidities, and clinical setting, adjusting for demographics.
Why it matters
Among 10,904 cognitively impaired participants, changes in AD drug management were associated with dyslipidemia, depression, and tobacco use, and changes in non-AD drug management were associated with depression, group practice, and area deprivation index in amyloid-positive participants. The study is about factors linked to medication management decisions, not about whether any treatment cures or prevents Alzheimer's disease.
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The overall sample (N =329) was predominantly female (76.4%) with a mean age of 64.5 (range 45-92) and an average of 14.9 years of education (Table 1).
Why it matters
This study found that depression mediated the link between neighborhood cohesion and cognitive impairment in Black older adults. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Identifying early markers of cognitive decline in cognitively normal older adults is critical for dementia prevention.
Why it matters
In cognitively normal older adults, slower gait speed was linked to higher CSF tau/Aβ42 and tTau/Aβ42 ratios and plasma NfL, and slower reaction time predicted lower baseline PACC scores. These simple sensorimotor measures may help identify people at risk of cognitive decline, but the study does not test any treatment or prevention.
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Identifying early markers of cognitive decline in cognitively normal older adults is critical for dementia prevention.
Why it matters
In cognitively normal older adults, slower gait speed was linked to higher CSF tau/Aβ42 and tTau/Aβ42 ratios and plasma NfL, and slower reaction time predicted lower baseline PACC scores. These simple sensorimotor measures may help identify people at risk of cognitive decline, but the study does not test any treatment or prevention.
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This study explored digital health literacy skills, self-efficacy in utilizing digital health resources, and self-efficacy in managing personal health among caregivers of individuals with Alzheimer's disease and related dementias (ADRD).
Why it matters
In a survey of 96 family and unpaid caregivers of people with Alzheimer's disease and related dementias, almost half lacked confidence in using digital health resources, though most used some digital tools. This describes caregiver digital health literacy and reports no treatment, cure, or prevention of Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam Study
- Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults
- A review of physical and cognitive interventions in aging
- Environmental risk factors for all-cause dementia, Alzheimer's disease dementia, vascular dementia, and mild cognitive impairment: An umbrella review and meta-analysis
- MRI-based hippocampal volume measurements in epilepsy
- Anticholinergic Drugs in Geriatric Psychopharmacology
- [Speech therapy after memory consultation: characteristics of patients receiving speech therapy sessions]
- Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin
- What predicts mortality in Parkinson disease?: a prospective population-based long-term study
- Fitness effects on the cognitive function of older adults: a meta-analytic study