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37/100

✓ Peer-reviewed alzhub usefulness score 37 out of 100. Brain scans and imaging

Topic: Risk, prevention and care in population studies

PREDICTOM MRI protocol contains eight different datatypes. Figure 1 and Figure 2 contain the main parameters and exemplary images in one healthy volunteer scanned in one of the PREDICTOM clinical centers. The choice of QSM was driven by its performance to better detect microbleeds (3). The MRS acquisition has been included due to consistent evidence of alterations in N-acetylaspartate and myo-Inositol in early stages of AD (4). For scanner with lower gradient performance, the rsfMRI protocol might use slightly partial Fourier and the multi-shell diffusion will be reduced to 2-shell protocol, excluding b=2000. The protocol has been tested on 4 scanners (2 vendors, 3 models) and the harmonisation is still in progress. The PREDICTOM MR protocol was designed to allow the exploration of existing and novel MRI biomarkers for early identification of people at high risk of developing AD. References 1. Brem AK, AAIC 2024. 2. Arani A, Alzheiemer´s & dementia 2024. 3. Lee K, Neuroimaging 2023. 4. Maul S, Frontiers in Psychiatry 2020.

Key findings

PREDICTOM MRI protocol contains eight different datatypes.
Figure 1 and Figure 2 contain the main parameters and exemplary images in one healthy volunteer scanned in one of the PREDICTOM clinical centers.
The choice of QSM was driven by its performance to better detect microbleeds (3).
The MRS acquisition has been included due to consistent evidence of alterations in N-acetylaspartate and myo-Inositol in early stages of AD (4).
For scanner with lower gradient performance, the rsfMRI protocol might use slightly partial Fourier and the multi-shell diffusion will be reduced to 2-shell protocol, excluding b=2000.

Why it matters

This paper describes the design of the PREDICTOM MRI protocol, which includes eight datatypes and was created to explore existing and novel MRI biomarkers for early identification of people at high risk of developing Alzheimer's disease. It is a protocol design for early identification, not a treatment, cure, or prevention study.

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Study details

Participants615
Evidence strengthLow

How this study scored 37/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	615 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 3 year(s) since 2025
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Suchandrima Banerjee: h-index 30 (OpenAlex, whole career)
Institution's track record	1 / 3	King's College London: institution h-index 1,348 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41447329)
Free to read	2 / 2	Free to read
Total	37 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Sanchez, A. B. S., Fernandez, B., Lythgoe, D. J., Dell’Acqua, F., Zelaya, F. O., Williams, S. C. R., et al. (2025). Rational and design of PREDICTOM MRI protocol. Alzheimer s & Dementia. https://doi.org/10.1002/alz70856_102571

Vancouver

Sanchez ABS, Fernandez B, Lythgoe DJ, Dell’Acqua F, Zelaya FO, Williams SCR, et al. Rational and design of PREDICTOM MRI protocol. Alzheimer s & Dementia. 2025. doi:10.1002/alz70856_102571. PMID: 41447329.

BibTeX

@article{sanchez2025-41447329,
  author  = {Sanchez, Ana Bea Solana and Fernandez, Brice and Lythgoe, David J. and Dell’Acqua, Flavio and Zelaya, Fernando O. and Williams, Steven CR and Venkataraman, Ashwin V. and Naeyaert, Maarten and others},
  title   = {{Rational and design of PREDICTOM MRI protocol}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_102571},
  pmid    = {41447329},
  url     = {https://doi.org/10.1002/alz70856_102571}
}

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