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A descriptive evaluation of eligibility for therapy among veterans with chronic hepatitis C virus infection
Muir AJ, Provenzale D.. Journal of clinical gastroenterology, 2002-03-01
Topic: Risk, prevention and care in population studies
Goal To assess the number of chronic hepatitis C patients eligible for therapy. Background Recent studies have shown improved response rates to treatment of chronic hepatitis C infection. However, treatment with interferon alfa has major side effects, and many patients may not be eligible for therapy. Study One hundred consecutive patients with positive hepatitis C serologies at the Durham Veterans Affairs Medical Center were evaluated. Medical records were reviewed, and the patients were interviewed. Patients were considered ineligible for therapy if they had severe mental illness, hazardous alcohol consumption, current drug abuse, decompensated cirrhosis, dementia, terminal illness, diabetic ketoacidosis, and severe cardiac or pulmonary disease or if they were homeless. Results Of the 100 patients, 92% were male and 51% were African American. The mean age was 47.3 +/- 5.6 years. Only 32 of the 100 patients were eligible for therapy. Hazardous alcohol consumption was present in 44%. Major depressive symptoms were present in 12%. Conclusions The minority of chronic hepatitis C patients were eligible for therapy. Significant rates of hazardous alcohol consumption and psychiatric disorders were present. For these patients to complete or become eligible for therapy, a multidisciplinary approach with psychiatric and substance abuse treatment will be necessary.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Muir, A. J., & Provenzale, D. (2002). A descriptive evaluation of eligibility for therapy among veterans with chronic hepatitis C virus infection. Journal of clinical gastroenterology. https://doi.org/10.1097/00004836-200203000-00015
Vancouver
Muir AJ, Provenzale D. A descriptive evaluation of eligibility for therapy among veterans with chronic hepatitis C virus infection. Journal of clinical gastroenterology. 2002. doi:10.1097/00004836-200203000-00015. PMID: 11873110.
BibTeX
@article{muir2002-11873110,
author = {Muir, A. J. and Provenzale, D.},
title = {{A descriptive evaluation of eligibility for therapy among veterans with chronic hepatitis C virus infection}},
journal = {Journal of clinical gastroenterology},
year = {2002},
doi = {10.1097/00004836-200203000-00015},
pmid = {11873110},
url = {https://doi.org/10.1097/00004836-200203000-00015}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Results Of the 100 patients, 92% were male and 51% were African American.
- Significant rates of hazardous alcohol consumption and psychiatric disorders were present.
Why it matters
This study found that only 32 of 100 chronic hepatitis C patients were eligible for therapy, with hazardous alcohol consumption and psychiatric disorders common. It does not address treating, curing or preventing Alzheimer's disease.
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Study details
- Participants100
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of clinical gastroenterology) |
| Journal's citation record | 2 / 4 | Journal of Clinical Gastroenterology: journal h-index 164 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2002 — older than 20 years, still counted |
| Sample size | 2 / 4 | 100 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 102 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.9 citations a year over 26 year(s) since 2002 |
| Impact for its field and year | 3 / 6 | Cited 6.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Dawn Provenzale: h-index 54 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Duke Medical Center: institution h-index 1,255 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 11873110) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
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