Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Little is known about the relationships between infections, sepsis and dysphagia.
Why it matters
This retrospective cross-sectional study found that dysphagia developed in some hospitalised patients with infections or sepsis, and that increasing age, sepsis, delirium, dementia and Parkinson's disease were significantly associated with increased risk. It is about swallowing problems during hospital infections, not about treating, curing or preventing Alzheimer's disease.
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Evidence on neighborhood food stores and public health is limited.
Why it matters
Older adults in Japan who reported fewer neighborhood food stores had less favorable outcomes in several health domains, including some related to physical and cognitive health. This is an observational study, so it cannot show that adding food stores would prevent dementia or improve health.
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Machine learning models consistently outperformed conventional approach.
Why it matters
This study reports that machine learning models using MoCA test data performed better than the standard cutoff for detecting cognitive impairment and classifying subtypes. It is a diagnostic aid only and does not test any treatment, cure or prevention.
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Oral health is strongly associated with overall health.
Why it matters
This article describes associations between oral health and overall health and notes that challenges in accessing dental services have been associated with worsening of systemic ailments including dementia. It does not report any treatment, cure, or prevention for Alzheimer's disease.
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MODERN MEDICINE VERSUS LIFESTYLE MEDICINE Conventional biomedicine excels in acute care, diagnostics, therapeutics and emergencies.
Why it matters
This review discusses lifestyle factors such as diet, exercise, sleep, and stress in relation to non-communicable diseases and mentions cognitive decline only in passing. It does not test or establish any treatment, cure, or prevention for Alzheimer's disease.
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During follow-up 20 SCD and 99 MCI patients developed dementia.
Why it matters
In non-demented elderly people, plasma GFAP, pTau181, and pTau217 improved individualized prediction of progression from MCI to dementia on top of age, sex, and MMSE, with models validated in a memory clinic setting. These models can estimate progression probabilities over 1, 3, and 5 years, but they are prognostic tools, not treatments, cures, or prevention.
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The mean age of the sample was 63 years (Q1, Q3, 56, 68); 56% were women.
Why it matters
In this UK Biobank cohort, for short sleepers, increasing sleep duration lowered dementia risk only when it replaced inactivity or light activity, not moderate-to-vigorous activity. For normal sleepers, replacing moderate-to-vigorous activity with sleep was linked to greater dementia risk, suggesting that balancing sleep and activity may matter for risk reduction.
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105 participants (47 Latino, 55 Black), 64.7 (±8.8) years-old, female 66 (63%), with 16 (±2.3) years of education were assessed.
Why it matters
In this small longitudinal study of 105 Latino and Black adults, many modifiable dementia risk factors were found, and objective measures revealed more unrecognized or undertreated factors than participants reported. It suggests active surveillance to detect and treat risk factors, but does not test a treatment, cure or prevention.
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These results provide clear evidence that CU older adults with both amyloid plaques and tau aggregates measured with PET will develop cognitive impairments if the disease is not stopped.
Why it matters
In cognitively unimpaired older adults who had both amyloid and tau detected on PET scans, all of the PREVENT-AD participants in this group progressed to mild cognitive impairment or dementia with additional follow-up. The authors state this shows such individuals will develop cognitive impairment if the disease is not stopped, though this finding comes from one study cohort.
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Predictive performance was comparable across algorithms, with R² ranging from 0.201 to 0.361, highest in the MCI_All dataset.
Why it matters
This interpretable machine learning analysis found that age and education were the strongest predictors of cognitive function, while modifiable factors such as oral health, depression, social engagement and IADL performance played significant roles across subgroups. The authors say this underscores the value of targeted interventions to reduce dementia risk, but the study itself identifies predictors rather than testing a treatment or prevention.
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Recommendations for HCAP adaptation include phases of preparation (assembling local expert teams; resource planning), implementation (construct-centered adaptation guided by local experts), pre-testing (iterative, mixed-methods approach), and field preparation (creating documentation; interviewer training; planning for ongoing quality assurance).
Why it matters
This paper offers recommended best practices for adapting the Harmonized Cognitive Assessment Protocol across countries, covering preparation, implementation, pre-testing and field preparation. It aims to improve cross-national data collection and research on cognitive aging and dementia, not to treat or cure the disease.
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Latino family caregivers of people with dementia face significant challenges and limited access to support.
Why it matters
This qualitative study explored barriers and facilitators to implementing a dementia caregiver support intervention for Latinos in primary care using community health workers. It concerns caregiver support and implementation, not treating, curing, or preventing Alzheimer's disease.
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= 0.026). Complementing previous research that focuses on CSVD and white matter changes, our study highlights abnormal gray matter integrity as a possible link between small vessel pathology and cognitive disorders.
Why it matters
This study highlights abnormal gray matter integrity as a possible link between small vessel pathology and cognitive disorders. It is an observational finding and does not report any treatment, cure or prevention.
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Person-centered care provides a critical framework for dementia support in long-term care facilities, emphasizing attention to each resident's evolving needs, personal history, preferences, and values.
Why it matters
This paper introduces an AI-enabled web platform designed to share care information among staff and families in long-term care and reports that it improved staff access to resident information and sustained family engagement without increasing caregiver burden. It is a care-coordination tool and does not test treating, curing, or preventing Alzheimer's disease.
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Diabetes is a global health concern associated with complications such as cognitive decline and dementia.
Why it matters
This systematic review found that hypoglycemic episodes are strongly associated with an increased risk of cognitive decline and dementia in people with diabetes. It underscores the importance of maintaining stable blood sugar levels, but does not test a treatment or cure for Alzheimer's disease.
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Among 1616 participants (AD = 1498, bvFTD = 118), all algorithms achieved high accuracy (80% to 90%) and discriminatory ability (AUC = 0.89 to 0.95).
Why it matters
Machine learning using neuropsychological and neuropsychiatric variables classified Alzheimer's disease versus behavioral variant frontotemporal dementia with 80% to 90% accuracy and AUC of 0.89 to 0.95. It supports differential diagnosis, not treatment, cure or prevention.
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Among 1013 participants, 847 screened positive on MoCA (70.4% mild, 13.2% moderate) for cognitive impairment and were assessed further for other domains of ICMR-MUDRA toolbox.
Why it matters
Among 1,013 older adults in India, 847 screened positive for cognitive impairment on MoCA, with males performing better than females across multiple cognitive domains. The authors suggest early public health interventions for middle-aged people to delay cognitive impairment.
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Cognitive decline occurred in 38.1% of participants but was not associated with MD adherence.
Why it matters
In this pooled cohort study, Mediterranean diet adherence was not associated with cognitive decline overall, but among high socioeconomic status individuals it was linked to reduced cognitive decline risk. No significant association was found between diet adherence and incident dementia regardless of socioeconomic status.
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Gait abnormalities are associated with cognitive decline, and reduced gait speed and gait asymmetry are markers of cognitive decline and increased fall risk in patients with established DLB.
Why it matters
In 63 patients with dementia with Lewy bodies, slower gait speed and shorter stride length were associated with lower cognitive scores and higher fall risk, with each 1 standard deviation decrease in gait speed raising fall risk by 33%. This is a cross-sectional study of gait and falls, not a test of treatment, cure, or prevention.
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We identified several key themes: surrogates more often chose comfort care for care recipients with dementia, particularly at advanced stages.
Why it matters
This study of free-text survey responses found that surrogates more often chose comfort care for care recipients with dementia, particularly at advanced stages, and many made decisions based on their own lived experiences or values rather than the patients' previously stated wishes. It also found that an AI chatbot's themes closely aligned with human-generated themes, but this concerns research methods rather than treatment, cure, or prevention.
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Among 500 dementia patients (mean age 78.3 ± 7.2 years), Kaplan-Meier analysis revealed significantly earlier pneumonia onset in severe dementia patients (log-rank P < 0.001), with Cox regression showing that severe dementia conferred triple the pneumonia risk (hazard ratio [HR] = 3.01, 95% confidence interval [CI]: 2.15-4.21) and that swallowing dysfunction independently increased the hazard ratio 3.45-fold (95% CI: 2.61-4.55); aspiration pneumonia accelerated cognitive decline (β = -2.35, 95% CI: -3.12 to -1.58).
Why it matters
In this retrospective cohort of 500 dementia patients, severe dementia was linked to triple the risk of pneumonia and swallowing dysfunction independently raised that risk, while aspiration pneumonia accelerated cognitive decline. The authors conclude that early management of swallowing problems and pneumonia prevention are crucial to disrupt this cycle, but this is about complications of dementia rather than curing or preventing Alzheimer's disease.
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During a 7-year median follow-up, type 2 diabetes was associated with the highest risk of all-cause dementia (hazard ratio [HR] 1.18, 95% confidence interval [CI]: 1.06 to 1.31), followed by hypertension and hyperlipidemia.
Why it matters
In people with mild cognitive impairment, type 2 diabetes carried the highest risk of all-cause dementia and vascular dementia, while hyperlipidemia was the only cardiometabolic factor significantly associated with Alzheimer's disease risk. These are observational risk associations and do not test any treatment, cure or prevention.
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Living with dementia requires decision making about numerous topics including daily activities and advance care planning (ACP).
Why it matters
This umbrella review of knowledge translation interventions found beneficial impacts such as increased knowledge and confidence and decreased decisional conflicts for people with dementia and care partners. Advance care planning was the most common decision topic.
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Frontotemporal dementia (FTD) is a neurodegenerative disorder primarily affecting the frontal and temporal lobes, leading to significant impairments in executive function, social behavior, and emotional regulation.
Why it matters
This narrative review explores decision-making deficits in frontotemporal dementia, noting that impaired performance on decision-making tasks may be an early and specific marker of the disease. It discusses neuropsychological and neuroimaging assessments but no treatment or cure.
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FAB-Ch scores were significantly lower in individuals with dementia compared to controls (p < .001).
Why it matters
The Frontal Assessment Battery could tell people with dementia from healthy controls but could not tell Alzheimer's disease from frontotemporal dementia. This tool may help characterize dementia severity but does not treat, cure, or prevent Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Neighborhood Food Environment and Dementia Incidence: the Japan Gerontological Evaluation Study Cohort Survey
- Effectiveness of Advance Care Planning for End-of-Life Outcomes in Nursing Home Residents With Dementia: A Systematic Review and Meta-Analysis
- Ethnicity and end-of-life care: the use of feeding tubes
- A relational approach to co-create Advance Care Planning with and for people living with dementia: a narrative study
- Levels of human immunodeficiency virus type 1 RNA in cerebrospinal fluid correlate with AIDS dementia stage
- Working memory and executive function decline across normal aging, mild cognitive impairment, and Alzheimer's disease
- Machine learning approaches to diagnosis and laterality effects in semantic dementia discourse
- The principles of Population-Level Approaches to Dementia Risk Reduction (PLADRR)
- At Home versus in a Nursing Home: Long-term Care Settings and Marginal Utility
- Keeping In Touch Everyday (KITE) project: developing assistive technologies with people with dementia and their carers to promote independence