Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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46/100
An international expert panel convened to evaluate nutrition-based approaches to brain health and dementia prevention.
Why it matters
This consensus statement concludes that the Mediterranean and MIND dietary patterns show promise for maintaining cognitive function, and that multi-domain interventions like FINGER can delay dementia onset in at-risk older adults. It is based on expert synthesis of existing evidence rather than new trial results, so it does not prove that any specific nutrition approach prevents or treats Alzheimer's disease.
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Of 289,649 included participants, 137,480 (47.5 %) were male, and the mean age was 56.6 ± 8.1 years.
Why it matters
People with moderate or high scores on a cardiovascular health measure had lower risks of later developing dementia and cardiovascular disease. The study does not test whether improving these health factors prevents dementia, and adding psychological health to the measure did not significantly improve its predictive performance.
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There were no significant associations in men.
Why it matters
In this cross-sectional study of Czech adults, women with higher Mediterranean diet scores had better verbal memory and overall cognitive scores, while no significant associations were found in men. The results suggest the Mediterranean diet may help improve cognitive functioning in women.
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Our results will provide new evidence of the efficacy of an innovative multi-component intervention integrating IVR and telemedicine in SCD individuals.
Why it matters
This is a study protocol for a randomized controlled trial that will test an immersive virtual reality and telemedicine-based intervention in 75 people with subjective cognitive decline. No results are available yet, so it cannot yet say whether the intervention affects dementia risk.
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In the fully adjusted model, the odds ratio (OR) for persistent loneliness was 1.47 (95% confidence interval [CI] 1.10, 1.95).
Why it matters
Persistent loneliness from midlife into older age and becoming lonely were associated with higher odds of dementia, while transient loneliness in midlife was not. The association weakened when adjusting for depression, and the study suggests that reducing loneliness might reduce or delay dementia onset.
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Half of the participants were over 70, with no formal education.
Why it matters
This study found that vision and hearing impairments were linked to higher risk of dementia in older adults in rural South Africa, and hearing impairment predicted higher dementia probability two years later. It suggests that addressing sensory impairments may be important for dementia prevention in this population.
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Dementia affects approximately 55 million people globally, with modifiable risk factors contributing significantly to its prevalence.
Why it matters
This analysis estimated that nearly half of dementia cases in Turkey could be prevented through targeting modifiable risk factors, with physical inactivity, social isolation, and low education being the largest contributors. Prevention efforts may need to focus more on women, who had a higher preventable fraction than men.
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46/100
Oral diseases have emerged as one of the most prevalent non-communicable diseases (NCDs) worldwide, with a high global average prevalence of 45%, affecting an estimated 3.5 billion people globally.
Why it matters
This article reviews the epidemiology, risk factors, and prevention of oral health problems in older adults, not Alzheimer's disease. It provides no information relevant to treating, curing, or preventing Alzheimer's disease.
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Science can help to target climate finance at better-quality adaptation.
Why it matters
This piece is about climate adaptation finance and contains no information on Alzheimer's disease. It reports no findings relevant to treating, curing or preventing dementia.
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The results indicated that residence location, alcohol consumption, life satisfaction, depressive symptoms, and education level are key factors influencing the risk of MCI among older adults with functional disability.
Why it matters
A neural network model predicted risk of mild cognitive impairment in older adults with functional disability, achieving an ROC AUC of 0.80, with residence location, alcohol consumption, life satisfaction, depressive symptoms and education level as key factors. This is an early screening tool, not a treatment or prevention for Alzheimer's disease.
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Diagnostic challenges stem from overlapping symptoms of co-occurring neurodevelopmental and psychiatric conditions, rendering standard dementia tools insufficient.
Why it matters
This consensus report discusses diagnostic challenges for dementia in autistic adults and recommends tailored evaluations, longitudinal assessments, and emerging biomarkers. It focuses on improving diagnosis and post-diagnostic support, not on treating, curing, or preventing Alzheimer's disease.
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Upon initiation of guanfacine, patients with delirium had a reduction in daily antipsychotic exposure and a decrease in positive delirium screens.
Why it matters
In this retrospective cohort of 56 hospitalised older adults, guanfacine for delirium management showed no statistically significant difference in antipsychotic use or dose before and after initiation. It is a small study about managing delirium behaviour, not about treating, curing or preventing Alzheimer's disease.
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Pulse pressure, but not mean arterial pressure, significantly mediated the relationship between age and white matter hyperintensity load.
Why it matters
Pulse pressure, but not mean arterial pressure, was linked to white matter hyperintensity load, which in turn was linked to lower cognitive scores across adulthood. The authors suggest that managing pulse pressure may help maintain brain health, but this is an observational finding and not a tested treatment.
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PurposeDelirium is a common yet preventable complication of hospitalization, surgery and illness that is associated with poor outcomes.
Why it matters
This paper describes the planned BASIL II study, which will validate two new delirium severity instruments, including one for patients with dementia. No results are reported yet, so it provides no evidence about treating, curing, or preventing Alzheimer's disease.
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Of 75 221 admissions, 62 188 (82.7%; 33 625 unique patients; mean age 80.2 years; 55.8% female) had a 4AT on admission.
Why it matters
Routinely collected 4AT scores were associated with clinically diagnosed dementia and could be used alongside other clinical indicators to identify patients with possible undiagnosed dementia for further assessment. This was an observational study of hospital admissions, not a test of any treatment or cure.
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The disease burden of ADD in China is heavier than in most countries and regions.
Why it matters
This analysis reports that the dementia burden in China has tripled and globally doubled by 2021, with smoking, high fasting plasma glucose, and high BMI as major risk factors. It calls for early intervention but tests no specific treatment, cure, or prevention.
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Within-day analyses revealed time with CRs was associated with increased HR, primarily due to negative interactions.
Why it matters
This study found that more time interacting with the care recipient was linked to increased heart rate in dementia caregivers, mainly due to negative interactions, and that interactions with friends buffered this effect. It points to possible ways to protect caregivers' cardiovascular health, but it did not test any treatment, cure or prevention for Alzheimer's disease.
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BackgroundPatients with dementia face driving difficulties and, at some point, cease driving.
Why it matters
In this 7-year study, older age, lower semantic verbal fluency, and worse tandem walking with reverse counting predicted driving cessation in people with mild cognitive impairment or mild Alzheimer's disease dementia. It does not test a treatment or cure, but it identifies factors that may help caregivers and clinicians anticipate when driving may need to stop.
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Current Care and Support: Four themes emerged: Communication with empathy; Written information valuable but could be overwhelming; Referrals provided but not necessarily followed; A focus on prescribed anti-dementia medications.
Why it matters
This study gathered perspectives of people recently diagnosed with dementia and their carers in Australia, identifying needs for clear, ongoing, individualized post-diagnostic support and guidance by a trusted professional. It concerns post-diagnostic support and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Nature-based Solutions (NbS) are increasingly recognized as effective measures for mitigating flood risks and enhancing climate change adaptation.
Why it matters
This study is about coastal flood risk reduction using nature-based solutions, not about Alzheimer's disease. It provides no information relevant to treating, curing, or preventing Alzheimer's disease.
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In years when older adults subjectively reported fewer difficulties with their finances, they objectively performed better at financial tasks and this relationship became stronger over 10 years.
Why it matters
This study found that older adults without dementia were aware of their financial abilities, while those with a dementia diagnosis were more likely to have financial anosognosia. It offers insights for early detection tools, but it does not test any treatment, cure or prevention for Alzheimer's disease.
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WMH shape is associated with long-term risk for dementia after 10 years in community-dwelling older adults.
Why it matters
In community-dwelling older adults, a more irregular shape of periventricular or confluent white matter hyperintensities was related to decline in memory, executive function, and processing speed over five years, while deep WMH shape showed no such associations. This suggests WMH shape may help predict short-term cognitive decline related to cerebrovascular disease, but it is an observational finding and not a treatment.
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The three cognitive assessment tools were valid for detecting subjects with MCI or dementia according to ROC analysis.
Why it matters
This cross-sectional study compared three cognitive assessment tools for detecting mild cognitive impairment and found the Brain Health Test-7 performed slightly better than the MoCA and MMSE. It is about diagnosis, not treatment, cure, or prevention.
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The review consistently identified high levels of perceived stress among dementia caregivers.
Why it matters
This review found consistently high levels of perceived stress among dementia caregivers, with elevated cortisol compared to non-caregivers. It addresses caregiver wellbeing rather than treating, curing or preventing Alzheimer's disease itself.
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BackgroundHigh blood pressure has been associated with dementia prevalence and incident.
Why it matters
In this cross-sectional study, office and 24-hour blood pressure levels were not associated with dementia, but greater 24-hour blood pressure variability was linked to lower cognitive scores and higher odds of dementia. This is an association at one point in time and does not show that reducing blood pressure variability would prevent dementia.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Review
- Circulating metabolomic profile of the MIND diet and its relation to cognition in middle‐aged and older adults
- Fidelity to a behavioral intervention to improve goals of care decisions for nursing home residents with advanced dementia
- Physio-Cognitive Decline Syndrome as the Phenotype and Treatment Target of Unhealthy Aging
- Associations of physical frailty, depression and their interaction with incident all‐cause dementia among older adults: evidence from three prospective cohorts
- Rural and Urban Differences in Dementia Diagnosis in the Western U.S
- Deficits in narrative discourse elicited by visual stimuli are already present in patients with mild cognitive impairment
- Cross‐Sectional Comparison of Structural MRI Markers of Impairment in a Diverse Cohort of Older Adults
- Loneliness and social isolation among informal carers of individuals with dementia: A systematic review and meta-analysis
- Prediabetes as a critical stage for risk of dementia and stroke: evidence from the UK Biobank and Mendelian randomization