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Association between high-density lipoprotein and cognitive impairment in the oldest old
van Exel E, de Craen AJ, Gussekloo J, Houx P, Bootsma-van der Wiel A, Macfarlane PW, Blauw GJ, Westendorp RG.. Annals of neurology, 2002-06-01
Topic: Risk, prevention and care in population studies
Low high-density lipoprotein cholesterol is associated with an increased risk for cardiovascular disease and stroke. At the same time, cardiovascular disease and stroke are important risk factors for dementia. We assessed the association between total and fractionated cholesterol and cognitive impairment and explored whether observed associations were dependent on or independent of atherosclerotic disease.
Key findings
- At the same time, cardiovascular disease and stroke are important risk factors for dementia.
- We assessed the association between total and fractionated cholesterol and cognitive impairment and explored whether observed associations were dependent on or independent of atherosclerotic disease.
- In a population-based study, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were measured in 561 subjects 85 years old and grouped in three equal strata representing decreasing serum concentrations.
- History of cardiovascular disease and stroke was determined.
Why it matters
In 561 people aged 85, this population-based study assessed whether total and fractionated cholesterol levels were associated with cognitive impairment. It reports an association only and does not test any treatment, cure or prevention for Alzheimer's disease.
Study details
- Participants561
- Evidence strengthLow
How this study scored 50/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | 3 / 4 | Annals of Neurology: journal h-index 437 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2002 — older than 20 years, still counted |
| Sample size | 2 / 4 | 561 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 190 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.3 citations a year over 26 year(s) since 2002 |
| Impact for its field and year | 3 / 6 | Cited 4.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 1 / 4 | Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Rudi G. J. Westendorp: h-index 117 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Leiden University Medical Center: institution h-index 930 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 12112077) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
van Exel, E., de Craen, A. J., Gussekloo, J., Houx, P., Bootsma-van der Wiel, A., Macfarlane, P. W., et al. (2002). Association between high-density lipoprotein and cognitive impairment in the oldest old. Annals of neurology. https://doi.org/10.1002/ana.10220
Vancouver
van Exel E, de Craen AJ, Gussekloo J, Houx P, Bootsma-van der Wiel A, Macfarlane PW, et al. Association between high-density lipoprotein and cognitive impairment in the oldest old. Annals of neurology. 2002. doi:10.1002/ana.10220. PMID: 12112077.
BibTeX
@article{vanexel2002-12112077,
author = {van Exel, E. and de Craen, A. J. and Gussekloo, J. and Houx, P. and Bootsma-van der Wiel, A. and Macfarlane, P. W. and Blauw, G. J. and Westendorp, R. G.},
title = {{Association between high-density lipoprotein and cognitive impairment in the oldest old}},
journal = {Annals of neurology},
year = {2002},
doi = {10.1002/ana.10220},
pmid = {12112077},
url = {https://doi.org/10.1002/ana.10220}
}
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