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Impact of APOE4‐related dementia risk in underrepresented groups from the All of Us research program
Valentina Ghisays, Ehsan Khajouei, Ignazio Stefano Piras, Michael H. Malek‐Ahmadi, Hillary D. Protas, Dhruman D. Goradia, Yinghua Chen, Marcus Naymik et al.. Alzheimer s & Dementia, 2025-06-01
Topic: Risk, prevention and care in population studies
There was a significantly higher risk of developing a dementia diagnosis in Hispanic/Latino and NHB participants than NHW participants and comparably increased dementia hazard ratios in the Hispanic/Latino, NHB, and NHW APOE4 carriers than non-carriers (hazard ratio [HR] [95% confidence interval {CI}] 1.54 [1.25-1.91], 1.25 [1.00-1.57], and 1.55 [1.40-1.72]). Compared to NHW individuals, Hispanic/Latino and NHB individuals are at higher risk of developing a "dementia diagnosis" and comparably higher risk in APOE4 carriers than non-carriers. Plasma AD biomarkers could clarify the proportion of dementia cases with and without AD and the impact of APOE4 on AD in these groups. HIGHLIGHTS: Hispanic/Latino and non-Hispanic Black individuals have a higher risk of all-cause dementia. The impact of apolipoprotein ε4 (APOE4) on dementia risk was similar in the studied ethnoracial groups. Plasma biomarkers could inform the risk of Alzheimer's disease (AD) and impact of APOE4 in these groups.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ghisays, V., Khajouei, E., Piras, I. S., Malek‐Ahmadi, M. H., Protas, H. D., Goradia, D. D., et al. (2025). Impact of APOE4‐related dementia risk in underrepresented groups from the All of Us research program. Alzheimer s & Dementia. https://doi.org/10.1002/alz.70245
Vancouver
Ghisays V, Khajouei E, Piras IS, Malek‐Ahmadi MH, Protas HD, Goradia DD, et al. Impact of APOE4‐related dementia risk in underrepresented groups from the All of Us research program. Alzheimer s & Dementia. 2025. doi:10.1002/alz.70245. PMID: 40501118.
BibTeX
@article{ghisays2025-40501118,
author = {Ghisays, Valentina and Khajouei, Ehsan and Piras, Ignazio Stefano and Malek‐Ahmadi, Michael H. and Protas, Hillary D. and Goradia, Dhruman D. and Chen, Yinghua and Naymik, Marcus and others},
title = {{Impact of APOE4‐related dementia risk in underrepresented groups from the All of Us research program}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.70245},
pmid = {40501118},
url = {https://doi.org/10.1002/alz.70245}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- There was a significantly higher risk of developing a dementia diagnosis in Hispanic/Latino and NHB participants than NHW participants and comparably increased dementia hazard ratios in the Hispanic/Latino, NHB, and NHW APOE4 carriers than non-carriers (hazard ratio [HR] [95% confidence interval {CI}] 1.54 [1.25-1.91], 1.25 [1.00-1.57], and 1.55 [1.40-1.72]).
- Compared to NHW individuals, Hispanic/Latino and NHB individuals are at higher risk of developing a "dementia diagnosis" and comparably higher risk in APOE4 carriers than non-carriers.
- Plasma AD biomarkers could clarify the proportion of dementia cases with and without AD and the impact of APOE4 on AD in these groups.
- HIGHLIGHTS: Hispanic/Latino and non-Hispanic Black individuals have a higher risk of all-cause dementia.
- The impact of apolipoprotein ε4 (APOE4) on dementia risk was similar in the studied ethnoracial groups.
Why it matters
This study found that Hispanic/Latino and non-Hispanic Black individuals had a higher risk of developing a dementia diagnosis, and the impact of APOE4 on dementia risk was similar across the studied ethnoracial groups. It addresses risk factors and disparities, not treating, curing, or preventing the disease.
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Study details
- Study designlongitudinal study
- Participants9,784
- Evidence strengthModerate
How this study scored 55/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 9,784 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Eric M. Reiman: h-index 151 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Arizona: institution h-index 1,336 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40501118) |
| Free to read | 2 / 2 | Free to read |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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