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55/100

✓ Peer-reviewed alzhub usefulness score 55 out of 100. How common it is

Topic: Risk, prevention and care in population studies

Of 2,218 participants, 237 (11%) developed dementia in the period 1992/3 to 2015/6. Participants ≥70 years more often reported sleep disturbances compared to those <70. Only for a short lag time (3 years), sleeping ≥9 h was associated with incident dementia. Sleeping ≤6 h, interrupted sleep and waking up early were associated with incident dementia, particularly for lag times ≥15 years. We found that the association of sleep disturbances with incident dementia becomes stronger with longer lag times (particularly ≥15 years). Studies with lag times <15 years may suffer from reverse causation due to the changes in sleep patterns caused by the prodromal phase of neurodegenerative disease. The association of sleeping ≥9 h and the incidence of dementia in analyses with a short lag time seem to be the result of reverse causation.

Key findings

Of 2,218 participants, 237 (11%) developed dementia in the period 1992/3 to 2015/6.
Participants ≥70 years more often reported sleep disturbances compared to those <70.
Only for a short lag time (3 years), sleeping ≥9 h was associated with incident dementia.
Sleeping ≤6 h, interrupted sleep and waking up early were associated with incident dementia, particularly for lag times ≥15 years.
We found that the association of sleep disturbances with incident dementia becomes stronger with longer lag times (particularly ≥15 years).

Why it matters

This cohort study found that sleeping six hours or less, interrupted sleep, and waking up early were associated with incident dementia, particularly with longer lag times of 15 years or more. The association between sleeping nine hours or more and dementia at a short lag time appeared to be the result of reverse causation.

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Study details

Study designcohort study
Participants2,218
Evidence strengthModerate

How this study scored 55/100

Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The Journal of Prevention of Alzheimer s Disease)
Journal's citation record	0 / 4	The Journal of Prevention of Alzheimer s Disease: journal h-index 63 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	3 / 4	2,218 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 7 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	2.3 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 4.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Dorly J. H. Deeg: h-index 102 (OpenAlex, whole career)
Institution's track record	1 / 3	Radboud University Nijmegen: institution h-index 1,143 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 8 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39863328)
Free to read	2 / 2	Free to read
Total	55 / 100	—

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Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

APA 7th

Alders, P., Kok, A. A. L., van Zutphen, E. M., Claassen, J. A., & Deeg, D. J. H. (2025). The effect of sleep disturbances on the incidence of dementia for varying lag times. The Journal of Prevention of Alzheimer s Disease. https://doi.org/10.1016/j.tjpad.2024.100024

Vancouver

Alders P, Kok AAL, van Zutphen EM, Claassen JA, Deeg DJH. The effect of sleep disturbances on the incidence of dementia for varying lag times. The Journal of Prevention of Alzheimer s Disease. 2025. doi:10.1016/j.tjpad.2024.100024. PMID: 39863328.

BibTeX

@article{alders2025-39863328,
  author  = {Alders, Peter and Kok, Almar A. L. and van Zutphen, Elisabeth Maria and Claassen, Jurgen A.H.R. and Deeg, Dorly J. H.},
  title   = {{The effect of sleep disturbances on the incidence of dementia for varying lag times}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2024.100024},
  pmid    = {39863328},
  url     = {https://doi.org/10.1016/j.tjpad.2024.100024}
}

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