Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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= 0.991). Optimal sleep modified both cognitive performance and dementia risk in individuals with focal epilepsy compared with stroke patients and healthy controls.
Why it matters
This cohort study found that optimal sleep modified both cognitive performance and dementia risk in people with focal epilepsy compared with stroke patients and healthy controls. Based on self-reported sleep data, the authors suggest that improving sleep may be an impactful intervention to improve cognition and reduce dementia risk, particularly in focal epilepsy.
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This study estimated the utilization and lifetime costs of formal care for AD dementia using longitudinal register data.
Why it matters
This register-based study estimated that lifetime formal care costs for people with Alzheimer's disease dementia in Sweden were about 2,440,000 SEK, compared with 510,000 SEK for matched controls, with drug prescriptions and social care use rising as disease severity increased. It describes the cost of care over the disease course and does not test any treatment, cure or prevention.
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Among the five personality domains, only extraversion was significantly associated with reduced odds of cognitive decline within the intervention group over 24 weeks (fully adjusted model: OR = 0.35; 95% CI: 0.15-0.82).
Why it matters
In this 24-week multidomain intervention study, only extraversion was associated with reduced odds of cognitive decline within the intervention group. It suggests personality may matter for prevention strategies, but it does not show that the intervention prevents dementia.
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Combining aerobic exercise with cognitive training improves clinical outcomes in older adults with MCI and may influence stress-related neurobiological pathways.
Why it matters
This randomized trial compared aerobic exercise combined with computer-based cognitive training against aerobic exercise with conventional cognitive training in older adults with mild cognitive impairment. It tests effects on cognition, functional independence, quality of life and salivary cortisol, but it does not show that these interventions treat, cure or prevent Alzheimer's disease.
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Approximately half (54.5%, 35/55) of participants showed a decline in RBMT scores during the 2-year follow-up and were defined as the memory decline group.
Why it matters
This community-based cohort study found that baseline eye-tracking-based cognitive assessment scores predicted future memory decline with an AUC-ROC of 0.709. The approach offers a rapid, objective, and low-burden method for screening the risk of future cognitive decline.
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The reviewed studies demonstrated that wearable sensors, particularly those employing multimodal data and personalized machine learning models, enable reliable detection of agitation symptoms and support timely, tailored interventions.
Why it matters
This scoping review found that wearable and multimodal sensor technologies may help detect agitation in dementia, but noted the research is still in early stages and needs large-scale, longitudinal validation. It concerns monitoring a symptom, not treating, curing or preventing Alzheimer's disease.
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56/100
Growing evidence suggests that peripheral diseases serve as risk factors for dementia, but the population-level burden of dementia associated with various peripheral diseases has remained unknown.
Why it matters
This analysis estimated that 16 peripheral diseases together accounted for about a third of dementia burden globally, with periodontal disease, liver cirrhosis, hearing loss, and vision loss among the largest contributors. These are population-level associations, so they suggest possible prevention targets but do not prove that treating these conditions prevents dementia.
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Individuals with both physical frailty and depression had the highest risk of dementia.
Why it matters
Across three large cohorts, frail older adults had a higher risk of developing all-cause dementia, and adding physical frailty and depression improved dementia risk prediction. This identifies frailty and depression as risk markers, but the study does not show that treating either one prevents dementia.
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Each 1-unit increase in cumulative score was associated with a 3%-8% higher dementia hazard across cohorts.
Why it matters
This multi-cohort study found that cumulative and variable depression symptom exposure independently predicted higher dementia risk, with sustained high exposure for 4 years conferring approximately 2.7-3.9× greater risk. It supports longitudinal mood monitoring and sustained management.
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Lecanemab was approved for early Alzheimer's disease in Japan, with ≈ 6000 patients treated in the first year post approval.
Why it matters
This survey of 311 Japanese specialists found that early access to lecanemab appears feasible but infrastructure and financial hurdles remain, with one fourth reporting tight outpatient space and staffing. It addresses real-world adoption and reimbursement, not whether the therapy cures or prevents Alzheimer's disease.
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Among 2,335 participants (mean age 52.3 ± 11.2 years; 56.6% women), CVD risk trajectories over 10 years were classified as accelerated increase (29.2%), moderate increase (30.9%), or stable (39.9%).
Why it matters
In this cohort, people whose cardiovascular risk factors rose faster over 10 years had a higher chance of later stroke and vascular dementia, but no link was seen with all-cause or nonvascular dementia. This suggests that tracking how cardiovascular risk changes over time, not just a single measurement, may matter for vascular dementia risk.
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In our dataset search, we identified 108 910 people with a record indicating dementia at any time.
Why it matters
In UK primary care, people with dementia were often prescribed antipsychotics for longer than recommended and sometimes started on higher than minimum doses. This suggests a need for better adherence to guidelines to reduce potential harms.
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Outdoor activity is linked to lower dementia risk, particularly in those living in more accessible GS.
Why it matters
In this UK Biobank cohort, higher outdoor physical activity was linked to lower risk of all-cause dementia, most strongly for vascular dementia, and the link was stronger among those living in areas with high residential green space. These are observational associations and do not prove that increasing activity or green space prevents dementia.
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Among the 393 497 All of Us participants with linked EHRs, we identified 9444 individuals (2.40%) with glaucoma diagnoses (excluding participants with diagnoses of dementia before glaucoma) and 37 776 matched controls without glaucoma.
Why it matters
In this large cohort, people with glaucoma were more likely to later be diagnosed with all-cause dementia, Alzheimer's disease, and vascular dementia, but this kind of study cannot show that glaucoma causes dementia. It does not test any treatment or prevention, so it does not show that treating glaucoma would lower dementia risk.
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Addressing modifiable dementia risk factors requires reliable risk assessment methods.
Why it matters
This review classified 45 dementia risk scores and found a pooled C-statistic of 0.69, with no validated risk scores for vascular dementia and methodological limitations relating to validation. It is about assessing dementia risk to inform risk reduction, not about treating or curing the disease.
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56/100
This study analyzed 13 yr of follow-up data from 188,594 participants to assess the relationship between CWP and cognitive outcomes, while exploring the mediating effects of brain structure and systemic inflammation.
Why it matters
People with chronic widespread pain had a higher risk of mild cognitive impairment and dementia, but the study found no evidence of a causal association between chronic widespread pain and dementia. The authors note that imprecision in the timing of mediator assessment means the mediation findings should be interpreted cautiously.
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This cohort study compares the risk of incident all-cause dementia among people with hearing loss who use vs do not use hearing aids.
Why it matters
This cohort study compares the risk of incident all-cause dementia among people with hearing loss who use versus do not use hearing aids. The available text does not report the results, so it cannot yet say whether hearing aid use changes dementia risk.
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The rural setting presented unique challenges including: low literacy rates (60.1% of participants had no schooling), diverse language use (primarily Giriama and Swahili), limited infrastructure (e.g., 44.8% of households had electricity), restrictive cultural norms that influenced data collection (e.g., in-home interviews were often conducted outdoors with destructions).
Why it matters
This paper describes strategies for adapting cognitive tests for use in a rural low-resource setting in Kenya. It is about improving assessment methods, not treating, curing, or preventing Alzheimer's disease.
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A decreasing linear trend was observed between higher levels of curry consumption and cognitive decline (p = 0.037).
Why it matters
In this population-based cohort, higher curry consumption was linked in a dose-dependent way to lower incidence of cognitive decline and mild cognitive impairment or dementia. This is an observational association and cannot prove that curcumin or curry prevents dementia.
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After the intervention, the CG showed significantly lower scores compared to all experimental groups.
Why it matters
In this 12-week trial, older adults with cognitive decline who did aerobic and strength training, with or without cognitive components, had better cognitive performance than the control group. This highlights the importance of maintaining functional abilities for preserving skills and independence in aging.
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56/100
We found no significant difference in dementia incidence over a 20‐year follow‐up period compared with matched TIA‐free controls.
Why it matters
This cohort study found no significant difference in dementia incidence over 20 years between people who had a transient ischemic attack and matched controls without one. The authors suggest that transient ischemic attack prompts treatment changes and behavioral shifts that lower cardiovascular risk.
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We identified 62 928 patients with OSA and 62 928 in the propensity score-matched comparison cohort (76% male, median age 52 years).
Why it matters
This Danish cohort study found a modest association between obstructive sleep apnoea and dementia, including Alzheimer's disease, with CPAP treatment attenuating the associations. It motivates early clinical detection of OSA as a potentially modifiable risk factor for subsequent dementia.
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Of 10 974 participants (60.0% female, mean [SD] age: 73.2 [6.8] years), 2445 developed incident all-cause dementia over 116 067 person-years of follow-up.
Why it matters
In this study of older adults, drinking sugar-sweetened or artificially sweetened beverages in later life was not linked to dementia risk. The authors note that possible effects of consuming these drinks earlier in life still need to be studied.
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Accumulating >300 min/week of MVPA, whether concentrated within 1-2 days or distributed evenly across the week, was associated with a decreased risk of dementia.
Why it matters
This UK Biobank cohort found that more than 300 minutes per week of moderate-to-vigorous activity was linked to lower dementia risk, whether spread out or concentrated on weekends. It is observational, so it cannot prove that activity prevents dementia.
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We found significant impacts of hypertension, diabetes and their comorbidity on cognitive impairment occurrence.
Why it matters
This case-control study in China found that hypertension, diabetes, and their comorbidity were associated with higher odds of cognitive impairment, with the strongest effects for dementia in people with both conditions and longer duration of comorbidity. It shows an association between these conditions and cognitive impairment, not that treating them prevents or cures Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Why do ethnic elders present later to UK dementia services? A qualitative study
- Trends in palliative care utilization among older adult decedents with and without cancer in Taiwan: a population-based comparative study
- The need for palliative care in Ireland: a population-based estimate of palliative care using routine mortality data, inclusive of nonmalignant conditions
- Burden and care time for dementia caregivers in the LIVE@Home.Path trial
- Community-based dementia screening initiative in Brunei: pilot study
- Vitamins in the Prevention and Support Therapy of Neurodegenerative Diseases
- Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence
- The relationship between sleep duration, cognition and dementia: a Mendelian randomization study
- Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings
- International conference on the healthy effect of virgin olive oil