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Digital biomarkers for early agitation detection in dementia: a scoping review of emerging wearable and smart technologies for personalized care
Alex Malioukis, R Sterling Snead, Julia Marczika, Radha Ambalavanan, Gideon Towett, Mercy Mbogori-Kairichi. Frontiers in Neurology, 2026-02-10
Topic: Risk, prevention and care in population studies
The reviewed studies demonstrated that wearable sensors, particularly those employing multimodal data and personalized machine learning models, enable reliable detection of agitation symptoms and support timely, tailored interventions. The concept of digital phenotyping emerged as a promising approach for capturing complex behavioral signatures, while user-centered design was identified as essential for adoption and long-term compliance. The evidence identified in this scoping review indicates that wearable and multimodal sensor technologies may offer promising approaches for monitoring agitation in dementia, while acknowledging that the research remains in early stages. We recommend future research focus on large-scale, longitudinal validation and the expansion of these tools to other populations with communication challenges, such as individuals with autism spectrum disorder or traumatic brain injury. Systematic review registration: https://doi.org/10.17605/OSF.IO/DNHYM.
Key findings
- The reviewed studies demonstrated that wearable sensors, particularly those employing multimodal data and personalized machine learning models, enable reliable detection of agitation symptoms and support timely, tailored interventions.
- The concept of digital phenotyping emerged as a promising approach for capturing complex behavioral signatures, while user-centered design was identified as essential for adoption and long-term compliance.
- The evidence identified in this scoping review indicates that wearable and multimodal sensor technologies may offer promising approaches for monitoring agitation in dementia, while acknowledging that the research remains in early stages.
- We recommend future research focus on large-scale, longitudinal validation and the expansion of these tools to other populations with communication challenges, such as individuals with autism spectrum disorder or traumatic brain injury.
- Systematic review registration: https://doi.org/10.17605/OSF.IO/DNHYM.
Why it matters
This scoping review found that wearable and multimodal sensor technologies may help detect agitation in dementia, but noted the research is still in early stages and needs large-scale, longitudinal validation. It concerns monitoring a symptom, not treating, curing or preventing Alzheimer's disease.
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Study details
- Study designsystematic review
- Evidence strengthHigh
How this study scored 56/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for sample size, effect reported and studied in people because the record does not state it. We have no data on senior author's track record and institution's track record, so those were left out: it earned 52 of the 93 points we could judge it on, which is 56 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in Neurology) |
| Journal's citation record | 2 / 4 | Frontiers in Neurology: journal h-index 162 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A systematic review of all the studies on the question |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | 1 / 7 | Cited 4 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 4 / 6 | Cited 12.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author Mercy Mbogori-Kairichi holds only 5 work(s), too few to judge a track record — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41743052) |
| Free to read | 2 / 2 | Free to read |
| Points | 52 / 93 | Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 52 of the 93 points we could judge it on is 56 out of 100. |
| Total | 56 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/fneur.2026.1683517
- PubMed: 41743052
- Original source →
- Free full text: Frontiers in Neurology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Malioukis, A., Snead, R. S., Marczika, J., Ambalavanan, R., Towett, G., & Mbogori-Kairichi, M. (2026). Digital biomarkers for early agitation detection in dementia: a scoping review of emerging wearable and smart technologies for personalized care. Frontiers in Neurology. https://doi.org/10.3389/fneur.2026.1683517
Vancouver
Malioukis A, Snead RS, Marczika J, Ambalavanan R, Towett G, Mbogori-Kairichi M. Digital biomarkers for early agitation detection in dementia: a scoping review of emerging wearable and smart technologies for personalized care. Frontiers in Neurology. 2026. doi:10.3389/fneur.2026.1683517. PMID: 41743052.
BibTeX
@article{malioukis2026-41743052,
author = {Malioukis, Alex and Snead, R Sterling and Marczika, Julia and Ambalavanan, Radha and Towett, Gideon and Mbogori-Kairichi, Mercy},
title = {{Digital biomarkers for early agitation detection in dementia: a scoping review of emerging wearable and smart technologies for personalized care}},
journal = {Frontiers in Neurology},
year = {2026},
doi = {10.3389/fneur.2026.1683517},
pmid = {41743052},
url = {https://doi.org/10.3389/fneur.2026.1683517}
}
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