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Newest in this topic

  1. Beyond Usual Pace: Quick Walking Speed and Brain Health Outcomes in the Framingham Heart Study 2026-10-15
  2. Long-term voluntary exercise reveals limited translation of hippocampal molecular responses into neuroprotection in 5xFAD mice 2026-09-24
  3. Exercise effects on balance confidence and concerns about falling in older adults with cognitive impairment: a construct-stratified meta-analysis 2026-09-14

Studies

125 studies carry this tag.

Date range

1996 to 2026

Top journals

  • Ageing research reviews 5
  • Journal of the American Geriatrics Society 5
  • Journal of Alzheimer's disease : JAD 4
  • Neurology 4
  • medRxiv 4

89 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Beyond Usual Pace: Quick Walking Speed and Brain Health Outcomes in the Framingham Heart Study

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-10-15 Risk factors

    We estimated associations per SD slower walking or smaller adaptability using linear, logistic, and Cox regression (10-year follow-up), overall and in women and men.

  2. Long-term voluntary exercise reveals limited translation of hippocampal molecular responses into neuroprotection in 5xFAD mice

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-09-24 Disease mechanisms

    Physical exercise promotes systemic and neural adaptations that support healthy brain aging and may mitigate Alzheimer’s disease (AD) progression.

  3. Exercise effects on balance confidence and concerns about falling in older adults with cognitive impairment: a construct-stratified meta-analysis

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-14 Mild cognitive impairment

    Older adults with mild cognitive impairment (MCI) or dementia have elevated fall risk, but fall-related psychological outcomes represent distinct constructs that should not be pooled indiscriminately.

  4. Forty participants completed the study (intervention, n = 21; control, n = 19).

  5. Global Research Landscapes and Emerging Trends in Music Therapy for Older Adults: A Comprehensive Bibliometric Analysis

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. F1000Res 2026-08-24 Health systems and care delivery

    Research on music therapy for older adults is a rapidly expanding and involves strong global collaboration.

  6. Individuals diagnosed with mild cognitive impairment (MCI) have an increased risk of developing dementia.

  7. Dynamic Interrelationships Among Physical Activity, Cognitive Function, and Depression in Older Adults: A Random-Intercept Cross- Lagged Panel Analysis

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-07-23 Prevention trials

    When stable individual differences are accounted for, depressive symptoms emerge as a stronger within-person temporal predictor of cognitive decline than physical activity.

  8. Differential association of step count with depressive and anxiety symptoms in older adults at risk of dementia

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-07-13 Clinical trials

    This provides the first evidence in older adults with cognitive concerns that higher step counts are associated with fewer depressive but more anxiety symptoms.

  9. A 12-week HIIT+RT intervention was more effective than HIIT alone in increasing the thickness/volume signature in individuals with CAD, yet no differences were observed compared to UC and the interventions did not affect the GMMD signature.

  10. Physical activity, aerobic fitness, and AD blood biomarkers: The IGNITE study

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2026-05 Biomarkers

    Greater MVPA (β = -0.107; p = 0.013) and CRF (β = -0.114; p = 0.027) were associated with lower NfL, but not Aβ PET, p-tau217, Aβ1-42/1-40, or GFAP.

  11. Exercise and Brain Health: Expert Review

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. American journal of lifestyle medicine 2026-01-09 Brain scans and imaging

    Preserving brain health is essential to maintaining quality of life and cognitive function with age.

  12. Fasted-State Aerobic Exercise Enhances Cognition and Hippocampal BDNF Signaling in an Alzheimer's Disease Rat Model

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurochemical research 2025-12-20 Prevention trials

    Alzheimer's disease (AD) is a multifactorial disorder that demands a comprehensive management strategy.

  13. Relationship between physical activity and biomarkers of pathology and neuroinflammation in preclinical autosomal-dominant Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Alzheimer's & dementia (New York, N. Y.) 2024-11-28 Biomarkers

    There were no associations among steps or TRIMP with plasma biomarkers or cognition.

  14. Sixteen trials, including 11,402 participants (mean age 73.2 [±5.5] years; 62.3 % female) were examined.

  15. Physical exercise, cognition, and brain health in aging

    ✓ Peer-reviewed alzhub usefulness score 71 out of 100. Trends in neurosciences 2024-05-28 Prevention trials

    Exercise training is an important strategy to counteract cognitive and brain health decline during aging.

  16. Safety and efficacy of acupuncture for mild cognitive impairment: a study protocol for clinical study

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Frontiers in neurology 2024-03-15 Cognitive tests and assessment

    The findings of this protocol will provide information regarding the effects of acupuncture on MCI.

  17. Harnessing digital health interventions to bridge the gap in prevention for older adults

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Frontiers in Public Health 2024-01-08 Cognitive tests and assessment

    The health issues associated with aging not only have a significant impact on the overall well-being of older individuals but also puts a lot of pressure of the healthcare system (3).

  18. Exercise training improves long-term memory in obese mice

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Life metabolism 2023-11-15 Prevention trials

    Obesity has been linked to a range of pathologies, including dementia.

  19. Physical activity, biomarkers of brain pathologies and dementia risk: Results from the Memento clinical cohort

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2023-07-08 Biomarkers

    Physical activity moderated the association between MTA and plasma Aβ42/40 level and increased dementia risk.

  20. Physical activity interventions in older adults with a cognitive impairment: A critical review of reviews

    ✓ Peer-reviewed alzhub usefulness score 70 out of 100. Aging medicine (Milton (N.S.W)) 2023-05-24 Prevention trials

    This critical review explores the review material on physical activity combined with cognitive stimulation interventions in older adults with cognitive impairment and/or dementia.

  21. Effectiveness of non-pharmacological therapies on cognitive function in patients with dementia-A network meta-analysis of randomized controlled trials

    ✓ Peer-reviewed alzhub usefulness score 78 out of 100. Frontiers in aging neuroscience 2023-03-02 Cognitive tests and assessment

    In this study, NPTs have excellent potential to improve cognition in people with dementia, and PBM may have more significant benefits in improving cognition than the other four NPTs.

  22. Cognitive interventions for memory and psychological well-being in aging and dementias

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in psychology 2023-02-02 Risk factors

    The human lifespan has expanded drastically in the last few centuries, due to improvements in sanitation, medicine, and nutrition, but with this increase in longevity comes higher rates of cognitive pathology such as mild cognitive impairment (MCI) and dementia; the latter is estimated to reach more than 75 million people by 2030.

  23. Can a serious game-based cognitive training attenuate cognitive decline related to Alzheimer's disease? Protocol for a randomized controlled trial

    ✓ Peer-reviewed alzhub usefulness score 79 out of 100. BMC psychiatry 2022-08-12 Cognitive tests and assessment

    The present study will address several shortcomings of previous CCT studies.

  24. Roles of physical activity and diet in cognitive aging: is more better?

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. The Clinical neuropsychologist 2022-04-10 Prevention and risk

    There was a significant interaction between PASE and MIND on executive functioning and total grey matter volume.

  25. Aerobic Training and Circulating Neurotrophins in Alzheimer's Disease Patients: A Controlled Trial

    ✓ Peer-reviewed alzhub usefulness score 70 out of 100. Experimental aging research 2022-03-06 Prevention trials

    After 12 weeks, maintenance of executive functioning in the TG was found, yet no significant changes on circulating neurotrophins levels were identified.

  26. Can exercise training teach us how to treat Alzheimer's disease?

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Ageing research reviews 2022-01-06 Prevention trials

    Alzheimer's disease (AD) is the most common cause of dementia and there is currently no cure.

  27. Associations of Physical Activity with Alzheimer's Disease Pathologies and Cognition: The CABLE Study

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Journal of Alzheimer's disease : JAD 2022 Biomarkers

    Regular physical activity was positively associated with CSF Aβ42 (p < 0.001) and Aβ42/40 (p < 0.001), while it was negatively associated with p-tau/Aβ42 (p < 0.001) and t-tau/Aβ42 (p < 0.001).

  28. [Physical Activity and Mental Health in the Elderly]

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Praxis 2022 Risk factors

    Physical Activity and Mental Health in the Elderly Abstract.

  29. Resistance-exercise training attenuates LPS-induced astrocyte remodeling and neuroinflammatory cytokine expression in female Wistar rats

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of applied physiology (Bethesda, Md. : 1985) 2021-12-23 Prevention trials

    Neuroinflammation is an early detectable marker of mild cognitive impairment, the transition state between normal cognition and dementia.

  30. Exercise interventions in Alzheimer's disease: A systematic review and meta-analysis of randomized controlled trials

    ✓ Peer-reviewed alzhub usefulness score 80 out of 100. Ageing research reviews 2021-09-30 Prevention trials

    28 studies (total n = 1337 participants, average age 79-90 years) were included in the systematic review, of which 21 could be meta-analyzed.

  31. Exercise Dose and Aerobic Fitness Response in Alzheimer's Dementia: Findings from the FIT-AD Trial

    ✓ Peer-reviewed alzhub usefulness score 79 out of 100. International journal of sports medicine 2021-09-07 Prevention trials

    The purpose of this study was to examine the effects of a 6-month cycling aerobic exercise intervention on cardiorespiratory fitness and the dose-response relationship in community-dwelling older adults with mild-to-moderate Alzheimer's dementia.

  32. The Central Mechanisms of Resistance Training and Its Effects on Cognitive Function

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Sports medicine (Auckland, N.Z.) 2021-08-21 Prevention trials

    Resistance exercise is used extensively in athletic and general populations to induce neuromuscular adaptations to increase muscle size and performance.

  33. The Effects of Multi-Domain Interventions on Cognition: A Systematic Review

    ✓ Peer-reviewed alzhub usefulness score 75 out of 100. Western journal of nursing research 2021-07-14 Prevention trials

    This review aimed to evaluate the effects of multi-domain interventions on cognition among individuals without dementia.

  34. The Effectiveness of Computerized Cognitive Training Combined With Whole Body Cryotherapy in Improving Cognitive Functions in Older Adults. A Case Control Study

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Frontiers in psychiatry 2021-06-25 Cognitive tests and assessment

    The results show evidence for increased performance in the assessment of general cognitive functioning in both EGs (p ≤ 0.05).

  35. White matter plasticity in healthy older adults: The effects of aerobic exercise

    ✓ Peer-reviewed alzhub usefulness score 71 out of 100. NeuroImage 2021-06-24 Prevention trials

    White matter deterioration is associated with cognitive impairment in healthy aging and Alzheimer's disease.

  36. Associations between physical activity types and multi-domain cognitive decline in older adults from the Three-city cohort

    ✓ Peer-reviewed alzhub usefulness score 68 out of 100. PloS one 2021-06-01 Prevention trials

    Several studies suggest that physical activity improves cognitive functions and reduces cognitive decline, whereas others did not find any evidence of a neuroprotective effect.

  37. Virtual Reality-Based Cognitive Stimulation on People with Mild to Moderate Dementia due to Alzheimer's Disease: A Pilot Randomized Controlled Trial

    ✓ Peer-reviewed alzhub usefulness score 77 out of 100. International journal of environmental research and public health 2021-05-16 Cognitive tests and assessment

    The use of ecologically oriented approaches with virtual reality (VR) depicting instrumental activities of daily living (IADL) is a promising approach for interventions on acquired brain injuries.

  38. The Effects of Aerobic Exercise in Patients with Early-Onset Dementia: A Scoping Review

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Dementia and geriatric cognitive disorders 2021-05-06 Prevention trials

    Early-onset dementia (EOD) defines all dementia related conditions with an onset before the age of 65 years.

  39. Placebo controlled phase II clinical trial: Safety and efficacy of combining intranasal insulin & acute exercise

    ✓ Peer-reviewed alzhub usefulness score 77 out of 100. Metabolic brain disease 2021-04-15 Clinical trials

    A growing number of investigations are exploring the utility of intranasal insulin as a means of mitigating cognitive decline.

  40. Aerobic exercise improves hippocampal blood flow for hypertensive Apolipoprotein E4 carriers

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2021-01-28 Prevention trials

    Cerebrovascular dysfunction likely contributes causally to Alzheimer's disease (AD).

  41. Exercise interventions for older adults with Alzheimer's disease: a systematic review and meta-analysis protocol

    ✓ Peer-reviewed alzhub usefulness score 70 out of 100. Systematic reviews 2021-01-04 Prevention trials

    This review is anticipated to yield clinically meaningful insight on the specific value of exercise for older adults with AD.

  42. Physical exercise protocols in animal models of Alzheimer's disease: a systematic review

    ✓ Peer-reviewed alzhub usefulness score 73 out of 100. Metabolic brain disease 2020-10-23 Prevention trials

    Several animal studies have showed the beneficial effects of physical exercise (PE) on brain function and health.

  43. A systematic review of physical activity and quality of life and well-being

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Translational behavioral medicine 2020-10-01 Prevention trials

    Maintaining or improving quality of life (QoL) and well-being is a universal goal across the lifespan.

  44. Associations Between Multidomain Lifestyle Interventions and Intrinsic Capacity Domains During Aging: A Narrative Review

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. JAR life 2020-09-03 Prevention trials

    Multidomain interventions were associated with improvements on locomotion (as measured by performance-based tests of lower-limb function) and vitality (as measured by handgrip strength); benefits on cognitive function were also found, in particular among populations at increased risk of dementia and when operationalizing strong multidomain interventions (eg, using regular exercise training instead of physical activity advices).

  45. Corticomotor Plasticity Predicts Clinical Efficacy of Combined Neuromodulation and Cognitive Training in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Frontiers in aging neuroscience 2020-07-08 Cognitive tests and assessment

    Combined rTMS and cognitive training may improve the cognitive status of AD patients, with TMS-induced cortical plasticity at baseline serving as predictor of therapeutic outcome for this intervention, and potential mechanism of action.

  46. Recommended physical activity and all cause and cause specific mortality in US adults: prospective cohort study

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. BMJ (Clinical research ed.) 2020-07-01 Prevention trials

    Adults who engage in leisure time aerobic and muscle strengthening activities at levels recommended by the 2018 physical activity guidelines for Americans show greatly reduced risk of all cause and cause specific mortality.

  47. Effects of Physical Activity on Brain Energy Biomarkers in Alzheimer's Diseases

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Diseases (Basel, Switzerland) 2020-06-08 Prevention trials

    The prevalence of dementia has substantially increased worldwide.

  48. Protocol of Aerobic Exercise and Cognitive Health (REACH): A Pilot Study

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Journal of Alzheimer's disease reports 2020-05-02 Prevention trials

    A growing body of evidence supports that aerobic exercise can decrease the risk of future cognitive impairment and Alzheimer's disease (AD).

  49. Effects of Computerized Cognitive Training and Tai Chi on Cognitive Performance in Older Adults With Traumatic Brain Injury

    ✓ Peer-reviewed alzhub usefulness score 73 out of 100. The Journal of head trauma rehabilitation 2020 Cognitive tests and assessment

    Compared with UC, CCT increased scores on the MDRS's total, attention, and memory and those on the Mini-Mental State Examination and Telephone Interview of Cognitive Status over the 6-month intervention; TC increased scores on the MDRS's total and conceptualization and those on the Mini-Mental State Examination over the 6-month intervention, while it also increased scores on the MDRS's total and initiation/preservation and those on the Telephone Interview of Cognitive Status and reduced the time to complete the Trail Making Test B over the 12-month study.

  50. Physical Inactivity is Liable to the Increased Cardiovascular Risk and Impaired Cognitive Profile

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Current Alzheimer research 2020 Risk factors

    A high rate of physical inactivity was found among those enrolled in this project.

From across this tag

6 of the 125 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 6. The same 6 appear here every time.

All topic tags with their study counts