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Physical Activity and Alzheimer's Disease: A Systematic Review
Stephen R, Hongisto K, Solomon A, Lönnroos E.. The journals of gerontology. Series A, Biological sciences and medical sciences, 2017-06-01
Topic: Brain imaging, connectivity and assessment
The current literature includes several studies investigating the association between physical activity and risk of Alzheimer's disease (AD). The aim of this review was to systematically evaluate available evidence on this association. Medline via PubMed and CINAHL databases were searched for original English language research articles assessing the relationship between physical activity and incident AD. The review was limited to prospective observational and intervention studies. Criteria for exclusion were studies focusing on individuals with dementia, cross-sectional study design, and case reports. The quality of included studies was assessed in 5 domains of bias. Twenty-four studies met the inclusion criteria. The number of participants ranged from 176 to 5,698. Follow-up time varied from 1 to 34 years. Physical activity was inversely associated with risk of AD in most studies (n = 18). Leisure-time physical activity was particularly protective against AD, but not work-related physical activity. The risk of bias assessment showed that overall quality of evidence was moderate for 16 and low for 8 studies. Beyond all the available general recommendations for health promotion, current evidence does not allow to draw specific practical recommendations concerning the types, frequency, intensity, or duration of physical activity that may be protective against AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Stephen, R., Hongisto, K., Solomon, A., & Lönnroos, E. (2017). Physical Activity and Alzheimer's Disease: A Systematic Review. The journals of gerontology. Series A, Biological sciences and medical sciences. https://doi.org/10.1093/gerona/glw251
Vancouver
Stephen R, Hongisto K, Solomon A, Lönnroos E. Physical Activity and Alzheimer's Disease: A Systematic Review. The journals of gerontology. Series A, Biological sciences and medical sciences. 2017. doi:10.1093/gerona/glw251. PMID: 28049634.
BibTeX
@article{stephen2017-28049634,
author = {Stephen, R. and Hongisto, K. and Solomon, A. and Lönnroos, E.},
title = {{Physical Activity and Alzheimer's Disease: A Systematic Review}},
journal = {The journals of gerontology. Series A, Biological sciences and medical sciences},
year = {2017},
doi = {10.1093/gerona/glw251},
pmid = {28049634},
url = {https://doi.org/10.1093/gerona/glw251}
}
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Key findings
- Physical activity was inversely associated with risk of AD in most studies (n = 18).
- The risk of bias assessment showed that overall quality of evidence was moderate for 16 and low for 8 studies.
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Study details
- Study designcross-sectional
- Participants18
- Evidence strengthLow
How this study scored 66/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 38 of the 58 points we could judge it on, which is 66 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The journals of gerontology. Series A, Biological sciences and medical sciences) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A systematic review of all the studies on the question (from PubMed type “Systematic Review”) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 18 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28049634) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 38 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 38 of the 58 points we could judge it on is 66 out of 100. |
| Total | 66 / 100 | — |
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