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Physical activity, biomarkers of brain pathologies and dementia risk: Results from the Memento clinical cohort
Leslie Grasset, Vincent Planche, Vincent Bouteloup, Chabha Azouani, Bruno Dubois, Frédéric Blanc, Claire Paquet, Renaud David et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023-07-08
Topic: Brain imaging, connectivity and assessment
Physical activity moderated the association between MTA and plasma Aβ42/40 level and increased dementia risk. Compared to participants with low physical activity, associations of both MTA and plasma Aβ42/40 on dementia risk were attenuated in participants with high physical activity. Although reverse causality cannot be excluded, this work suggests that physical activity may contribute to cognitive reserve. HIGHLIGHTS: Physical activity is an interesting modifiable target for dementia prevention. Physical activity may moderate the impact of brain pathology on dementia risk. Medial temporal lobe atrophy and plasma amyloid beta 42/40 ratio were associated with increased dementia risk especially in those with low level of physical activity.
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APA 7th
Grasset, L., Planche, V., Bouteloup, V., Azouani, C., Dubois, B., Blanc, F., et al. (2023). Physical activity, biomarkers of brain pathologies and dementia risk: Results from the Memento clinical cohort. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.13360
Vancouver
Grasset L, Planche V, Bouteloup V, Azouani C, Dubois B, Blanc F, et al. Physical activity, biomarkers of brain pathologies and dementia risk: Results from the Memento clinical cohort. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023. doi:10.1002/alz.13360. PMID: 37422285.
BibTeX
@article{grasset2023-37422285,
author = {Grasset, Leslie and Planche, Vincent and Bouteloup, Vincent and Azouani, Chabha and Dubois, Bruno and Blanc, Frédéric and Paquet, Claire and David, Renaud and others},
title = {{Physical activity, biomarkers of brain pathologies and dementia risk: Results from the Memento clinical cohort}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2023},
doi = {10.1002/alz.13360},
pmid = {37422285},
url = {https://doi.org/10.1002/alz.13360}
}
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Key findings
- Physical activity moderated the association between MTA and plasma Aβ42/40 level and increased dementia risk.
- Compared to participants with low physical activity, associations of both MTA and plasma Aβ42/40 on dementia risk were attenuated in participants with high physical activity.
- Although reverse causality cannot be excluded, this work suggests that physical activity may contribute to cognitive reserve.
- HIGHLIGHTS: Physical activity is an interesting modifiable target for dementia prevention.
- Physical activity may moderate the impact of brain pathology on dementia risk.
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Study details
- Participants1,044
- Evidence strengthModerate
How this study scored 59/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 33 of the 56 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,044 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37422285) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 33 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 33 of the 56 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
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