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64/100

✓ Peer-reviewed alzhub usefulness score 64 out of 100. Biomarkers

Topic: Amyloid, tau and blood-test diagnosis

Sleep duration is linked to amyloid-β clearance while physical activity is associated with brain volume maintenance. We investigate how sleep duration and physical activity are associated with cognition by testing if the associations between sleep duration or physical activity to cognition are explained by amyloid-β burden and brain volume, respectively. Results Aβ data were obtained from 4322 participants (1208 with MRI, 59% female, 29% amyloid positive). Sleep duration was associated with a Aβ composite score (β = -0.005, CI: (-0.01, -0.001)) and Aβ burden in the anterior cingulate (ACC) (β = -0.012, CI: (-0.017, -0.006)) and medial orbitofrontal cortices (MOC) (β = -0.009, CI: (-0.014, -0.005)). Composite (β = -1.54, 95% CI:(-1.93, -1.15)), ACC (β = -1.22, CI:(-1.54, -0.90)) and MOC (β = -1.44, CI:(-1.86, -1.02)) Aβ deposition was associated with PACC. Physical activity was associated with hippocampal (β = 10.57, CI: (1.06, 20.08)), parahippocampal (β = 9.3, CI: (1.69, 16.91)), entorhinal (β = 14.68, CI: (1.75, 27.61), and fusiform gyral (β = 38.38, CI: (5.57, 71.18)) volumes, which were positively associated with PACC (p Discussion Sleep duration and physical activity are associated with cognition through independent paths of brain Aβ and brain volume, respectively. These findings implicate neural and pathological mechanisms for the relationships between sleep duration and physical activity on cognition.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Aslanyan, V., Ortega, N., Fenton, L., Harrison, T. M., Raman, R., Mack, W. J., et al. (2023). Protective effects of sleep duration and physical activity on cognitive performance are influenced by β-amyloid and brain volume but not tau burden among cognitively unimpaired older adults. NeuroImage. Clinical. https://doi.org/10.1016/j.nicl.2023.103460

Vancouver

Aslanyan V, Ortega N, Fenton L, Harrison TM, Raman R, Mack WJ, et al. Protective effects of sleep duration and physical activity on cognitive performance are influenced by β-amyloid and brain volume but not tau burden among cognitively unimpaired older adults. NeuroImage. Clinical. 2023. doi:10.1016/j.nicl.2023.103460. PMID: 37379733.

BibTeX

@article{aslanyan2023-37379733,
  author  = {Aslanyan, V. and Ortega, N. and Fenton, L. and Harrison, T. M. and Raman, R. and Mack, W. J. and Pa, J.},
  title   = {{Protective effects of sleep duration and physical activity on cognitive performance are influenced by β-amyloid and brain volume but not tau burden among cognitively unimpaired older adults}},
  journal = {NeuroImage. Clinical},
  year    = {2023},
  doi     = {10.1016/j.nicl.2023.103460},
  pmid    = {37379733},
  url     = {https://doi.org/10.1016/j.nicl.2023.103460}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

Sleep duration is linked to amyloid-β clearance while physical activity is associated with brain volume maintenance.
We investigate how sleep duration and physical activity are associated with cognition by testing if the associations between sleep duration or physical activity to cognition are explained by amyloid-β burden and brain volume, respectively.
Results Aβ data were obtained from 4322 participants (1208 with MRI, 59% female, 29% amyloid positive).
Sleep duration was associated with a Aβ composite score (β = -0.005, CI: (-0.01, -0.001)) and Aβ burden in the anterior cingulate (ACC) (β = -0.012, CI: (-0.017, -0.006)) and medial orbitofrontal cortices (MOC) (β = -0.009, CI: (-0.014, -0.005)).
Composite (β = -1.54, 95% CI:(-1.93, -1.15)), ACC (β = -1.22, CI:(-1.54, -0.90)) and MOC (β = -1.44, CI:(-1.86, -1.02)) Aβ deposition was associated with PACC.

Why it matters

In 4322 participants, sleep duration was associated with cognition through amyloid burden and physical activity through brain volume, with these paths being independent. This is about how lifestyle factors relate to cognition via brain pathology and structure, not a proven way to prevent or cure Alzheimer's disease.

New to this subject? Start with our plain-English guide: Blood tests & biomarkers →

Study details

Study designcross-sectional
Participants4,322
Evidence strengthHigh

How this study scored 64/100

Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for effect reported because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (NeuroImage. Clinical)
Journal's citation record	1 / 4	NeuroImage Clinical: journal h-index 133 (OpenAlex, 2026-10-29)
Study design	11 / 12	A randomised controlled trial (from PubMed type “Randomized Controlled Trial”)
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2023 — within 6 year(s) of the newest study here
Sample size	3 / 4	4,322 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	1 / 2	Randomised (as stated in the record)
Times cited	3 / 7	Cited 20 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	4.0 citations a year over 5 year(s) since 2023
Impact for its field and year	3 / 6	Cited 3.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	2 / 4	Cited 19 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Judy Pa: h-index 32 (OpenAlex, whole career)
Institution's track record	2 / 3	University of California, Berkeley: institution h-index 2,012 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 37379733)
Free to read	2 / 2	Free to read
Total	64 / 100	—

What each of these 20 components measures, and what this score is not →

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