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Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease
Kristian S Frederiksen, Karine Madsen, Birgitte B Andersen, Nina Beyer, Ellen Garde, Peter Høgh, Gunhild Waldemar, Steen G Hasselbalch et al.. Alzheimer's & dementia (New York, N. Y.), 2019-06-07
Topic: Brain imaging, connectivity and assessment
The intervention showed no effect on follow-up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini-Mental State Examination as predictors. Change in SUVRs did not correlate with changes in measures of physical or aerobic fitness. The present findings do not support an effect of exercise on Aβ. However, the relatively short intervention period may account for a lack of efficacy. Further studies should test earlier and longer interventions.
Key findings
- The intervention showed no effect on follow-up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini-Mental State Examination as predictors.
- Change in SUVRs did not correlate with changes in measures of physical or aerobic fitness.
- The present findings do not support an effect of exercise on Aβ.
- However, the relatively short intervention period may account for a lack of efficacy.
- Further studies should test earlier and longer interventions.
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Study details
- Evidence strengthHigh
How this study scored 50/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (New York, N. Y.)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31198839) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Frederiksen, K. S., Madsen, K., Andersen, B. B., Beyer, N., Garde, E., Høgh, P., et al. (2019). Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). https://doi.org/10.1016/j.trci.2019.04.006
Vancouver
Frederiksen KS, Madsen K, Andersen BB, Beyer N, Garde E, Høgh P, et al. Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). 2019. doi:10.1016/j.trci.2019.04.006. PMID: 31198839.
BibTeX
@article{frederiksen2019-31198839,
author = {Frederiksen, Kristian S and Madsen, Karine and Andersen, Birgitte B and Beyer, Nina and Garde, Ellen and Høgh, Peter and Waldemar, Gunhild and Hasselbalch, Steen G and others},
title = {{Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease}},
journal = {Alzheimer's \& dementia (New York, N. Y.)},
year = {2019},
doi = {10.1016/j.trci.2019.04.006},
pmid = {31198839},
url = {https://doi.org/10.1016/j.trci.2019.04.006}
}
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