- 1,308studies, of 27,380 in the library
- 1,234peer-reviewed
- 1964–2026years published
- 53median usefulness score out of 100
These counts and lists are worked out from the library itself each time the page loads. A score rates how much weight a study can bear — its design, journal, evidence and recency — not whether its result is good news. The study type is the one each record states; a record with no stated design is not counted here.
The 20 highest-scoring
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Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
In dominantly inherited Alzheimer's disease, declines in cerebrospinal fluid amyloid-beta 42 appeared 25 years before expected symptom onset, amyloid deposition and increased tau and brain atrophy 15 years before, cerebral hypometabolism and impaired episodic memory 10 years before, and global cognitive impairment 5 years before. The authors note these results require confirmation with longitudinal data and may not apply to patients with sporadic Alzheimer's disease.
- 27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial
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Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders
In three cohorts, plasma P-tau217 distinguished Alzheimer's disease from other neurodegenerative disorders with higher accuracy than some other blood markers. This is a diagnostic accuracy study, not a treatment or cure.
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Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum
Plasma GFAP levels were higher in people with preclinical Alzheimer's disease than in cognitively unimpaired individuals without amyloid, and were linked to tau pathology only when amyloid pathology was also present. This points to plasma GFAP as a possible biomarker for detecting and tracking Alzheimer's disease, not as a treatment or cure.
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Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden
Two surveys of people aged 75 and over in central Stockholm, in 1987-1989 (1,700 people) and 2001-2004 (1,575 people), diagnosed dementia with the identical procedure, so the two periods can be compared fairly. The authors report that the changes "suggest decreasing incidence" of dementia, meaning fewer new cases. The summary stored here gives no figures and names no cause. This is one district's trend in how often dementia occurs. It does not show that anything prevents dementia.
- Sleep Characteristics and Risk of Stroke and Dementia: An Observational and Mendelian Randomization Study
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Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease
In people with inherited Alzheimer's disease, the rate of change of serum neurofilament light distinguished mutation carriers from non-carriers about a decade earlier than single measurements and predicted brain shrinkage and cognitive change. This is a marker of progression, not a treatment or cure.
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Association of Sleep-Disordered Breathing With Alzheimer Disease Biomarkers in Community-Dwelling Older Adults: A Secondary Analysis of a Randomized Clinical Trial
This secondary analysis of a randomized clinical trial examined which brain changes, including amyloid deposition, gray matter volume, perfusion, and glucose metabolism, are associated with sleep-disordered breathing in cognitively unimpaired older adults. The authors say the results support screening and treating sleep-disordered breathing to reduce Alzheimer disease risk, but this cross-sectional analysis cannot show that treatment prevents the disease.
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Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease
In 2,916 cognitively unimpaired participants, plasma p-tau217 classified amyloid status both as a stand-alone test and in a two-step approach where positive results were confirmed with PET or cerebrospinal fluid. This supports using blood tests to identify preclinical Alzheimer's disease, though the study was cross-sectional.
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Diagnostic accuracy of plasma p-tau217/Aβ42 for Alzheimer's disease in clinical and community cohorts
A plasma p-tau217/Aβ42 ratio test detected abnormal amyloid and tau PET status with high accuracy in both clinic and community cohorts, comparable to cerebrospinal fluid tests and better than other blood markers tested. A two-cutoff approach improved specificity without reducing sensitivity, supporting its use for clinical diagnosis and community screening.
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Performance of Fully Automated Plasma Assays as Screening Tests for Alzheimer Disease-Related β-Amyloid Status
In 842 adults aged 59–88 (average 72, 52.5% women), including people with and without cognitive impairment, researchers tested fully automated blood assays as screening tests for Alzheimer's-related β-amyloid. Combined with APOE gene type, the tests reached an accuracy score (AUC) of 0.85 (95% CI 0.82–0.88), and the results were "similar in CU and cognitively impaired participants, and in younger and older participants." This is a screening-accuracy result for amyloid status, not a dementia diagnosis or a treatment, and the record we hold does not report how the blood tests did without APOE.
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Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission Tomography
In this cross-sectional study, CSF p-tau at all four phosphorylation sites assessed was more closely associated with amyloid PET than with tau PET. The authors highlight the need for careful interpretation of p-tau biomarkers within the A/T/(N) framework; no treatment was tested.
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Estimating the Prevalence of Dementia and Mild Cognitive Impairment in the US: The 2016 Health and Retirement Study Harmonized Cognitive Assessment Protocol Project
In this nationally representative sample, every 5-year increase in age was associated with higher risk of dementia and mild cognitive impairment, and each additional year of education was associated with a decrease in risk of both. Dementia was more common among non-Hispanic Black individuals and mild cognitive impairment was more common among Hispanic individuals compared with non-Hispanic White individuals.
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Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders
This study found that [18F]flortaucipir PET could discriminate Alzheimer disease from other neurodegenerative diseases in patients with established diagnoses at a memory disorder clinic. It is a diagnostic accuracy study, not a treatment, cure or prevention for Alzheimer's disease.
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Long-term health benefits of physical activity--a systematic review of longitudinal studies
This review of longitudinal studies found that physical activity appears to have a positive long-term influence on all the diseases examined, including Alzheimer's disease and dementia. It also notes a shortage of long-term studies on physical activity and these diseases.
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Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women
In a group of 298 older women, the 105 with sleep-disordered breathing went on to develop mild cognitive impairment or dementia more often than the 193 without it (44.8% vs 31.1%; adjusted odds ratio 1.85). Frequent drops in blood oxygen during sleep and more sleep time spent in apnea or hypopnea were also linked to higher risk, but broken sleep and total sleep time were not. This is an association in women only; the study did not test whether treating sleep-disordered breathing lowers that risk.
- Dying with dementia: symptom burden, quality of care, and place of death
- Cross-Sectional and Longitudinal Diagnostic Performance of Plasma p-tau217 and p-tau217/Aβ42 in Alzheimer's Disease
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Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum
CSF-based estimates of amyloid abnormality were up to 10% higher than PET-based estimates in people without dementia, suggesting preclinical and prodromal Alzheimer's disease may be more common than previously estimated. This affects trial recruitment and health care planning, not treatment or cure.
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The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort
In this five-year follow-up of people with Parkinson's disease, three things measured at the start predicted who later developed dementia: being 72 or older, naming fewer than 20 words in a 90-second word-category test, and being unable to copy a drawing of intersecting pentagons. A variant of the tau gene (MAPT H1/H1) also predicted dementia, with an odds ratio of 12.1, while difficulties on planning-type "frontal" tasks did not and, the authors suggest, follow a separate course with a "better prognosis". These are risk markers from one group of patients, not a diagnostic test, and the study tested no treatment or prevention.
See all 1,308 studies, with filters →
Newest additions
- Blood-based biomarkers across the Alzheimer's disease continuum in older Korean population
- The Contribution of Routinely Collected Clinical Data to Dementia Identification in Primary Care: A Cross-Sectional Study
- Development and Preliminary Psychometric Evaluation of a Questionnaire Assessing Nursing Students’ Perceived Capability to Recognise Dementia in Women
- Prevalence of dementia and mild cognitive impairment in Morocco: A population-based study
- Amyloid and Tau Neuropathologic Stage, Coexisting Brain Disease, and Cognitive Status in a Population-Based Autopsy Cohort
- α-Synuclein Seed Amplification Status Modifies the Relationship Between Plasma p-tau217, Amyloid and Fibrillar Tau
- Functional neuroimaging as a tool to understand social determinants of health in cognitive aging and ADRD: a scoping review
- Plasma Neurofilament Light Chain is Markedly Elevated in General Hospital Inpatients with Delirium
- Cognitive Impairment during Migraine Attacks: An Analysis from the American Registry for Migraine Research (ARMR)
- “The conversation wouldn’t happen without us”: How interpreter involvement affects dementia service delivery for CALD clients in Australia
By review status
- Peer-reviewed — 1,234
- Preprint — not yet peer-reviewed — 73
- Conference abstract — not peer-reviewed — 1