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Exercise and Alzheimer's disease biomarkers in cognitively normal older adults
Liang KY, Mintun MA, Fagan AM, Goate AM, Bugg JM, Holtzman DM, Morris JC, Head D.. Annals of neurology, 2010-09-01
Topic: Plasma and spinal-fluid biomarkers
Objective In addition to the increasingly recognized role of physical exercise in maintaining cognition, exercise may influence Alzheimer's disease (AD) pathology, as transgenic mouse studies show lowered levels of AD pathology in exercise groups. The objective of this study was to elucidate the association between exercise and AD pathology in humans using Pittsburgh compound-B (PIB), amyloid-beta (Abeta)(42), tau, and phosphorylated tau (ptau)(181) biomarkers. Methods Sixty-nine older adults (17 males, 52 females) aged 55 to 88 years, were recruited and confirmed to be cognitively normal. A questionnaire on physical exercise levels over the past decade was administered to all. Cerebrospinal fluid samples were collected from 56 participants, and amyloid imaging with PIB was performed on 54 participants. Results Participants were classified based on biomarker levels. Those with elevated PIB (p = 0.030), tau (p = 0.040), and ptau(181) (p = 0.044) had significantly lower exercise, with a nonsignificant trend for lower Abeta(42) (p = 0.135) to be associated with less exercise. Results were similar for PIB after controlling for covariates; tau (p = 0.115) and ptau(181) (p = 0.123) differences were reduced to nonsignificant trends. Additional analyses also demonstrated that active individuals who met the exercise guidelines set by the American Heart Association had significantly lower PIB binding and higher Abeta(42) levels with and without controlling for covariates (PIB: p = 0.006 and p = 0.001; Abeta(42): p = 0.042 and p = 0.046). Last, the associations between exercise engagement and PIB levels were more prominent in APOE epsilon 4 noncarriers. Interpretation Collectively, these results are supportive of an association between exercise engagement and AD biomarkers in cognitively normal older adults.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Liang, K. Y., Mintun, M. A., Fagan, A. M., Goate, A. M., Bugg, J. M., Holtzman, D. M., et al. (2010). Exercise and Alzheimer's disease biomarkers in cognitively normal older adults. Annals of neurology. https://doi.org/10.1002/ana.22096
Vancouver
Liang KY, Mintun MA, Fagan AM, Goate AM, Bugg JM, Holtzman DM, et al. Exercise and Alzheimer's disease biomarkers in cognitively normal older adults. Annals of neurology. 2010. doi:10.1002/ana.22096. PMID: 20818789.
BibTeX
@article{liang2010-20818789,
author = {Liang, K. Y. and Mintun, M. A. and Fagan, A. M. and Goate, A. M. and Bugg, J. M. and Holtzman, D. M. and Morris, J. C. and Head, D.},
title = {{Exercise and Alzheimer's disease biomarkers in cognitively normal older adults}},
journal = {Annals of neurology},
year = {2010},
doi = {10.1002/ana.22096},
pmid = {20818789},
url = {https://doi.org/10.1002/ana.22096}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Results Participants were classified based on biomarker levels.
- Those with elevated PIB (p = 0.030), tau (p = 0.040), and ptau(181) (p = 0.044) had significantly lower exercise, with a nonsignificant trend for lower Abeta(42) (p = 0.135) to be associated with less exercise.
- Results were similar for PIB after controlling for covariates; tau (p = 0.115) and ptau(181) (p = 0.123) differences were reduced to nonsignificant trends.
- Additional analyses also demonstrated that active individuals who met the exercise guidelines set by the American Heart Association had significantly lower PIB binding and higher Abeta(42) levels with and without controlling for covariates (PIB: p = 0.006 and p = 0.001; Abeta(42): p = 0.042 and p = 0.046).
- Interpretation Collectively, these results are supportive of an association between exercise engagement and AD biomarkers in cognitively normal older adults.
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Study details
- Participants56
- Evidence strengthLow
How this study scored 47/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 27 of the 58 points we could judge it on, which is 47 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2010 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 56 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 20818789) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 27 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 27 of the 58 points we could judge it on is 47 out of 100. |
| Total | 47 / 100 | — |
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