Sixteen trials, including 11,402 participants (mean age 73.2 [±5.5] years; 62.3 % female) were examined. 5 key findings →
Participants: 11,402 Evidence: high
Full summary, score breakdown and related studies → Original source
Research
27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
As the first NMA comparing different interventions for AD and MCI, our study suggests that PE and CCT might have a significant improvement in cognition and neuropsychiatric symptoms respectively. 4 key findings →
Design: meta-analysis Participants: 1,747 Evidence: high
Full summary, score breakdown and related studies → Original source
Exercise interventions were performed 3.4 ± 1.4 days per week at moderate intensity (3.7 ± 0.6 metabolic equivalents) for 45.2 ± 17.0 minutes per session for 18.6 ± 10.0 weeks and consisted primarily of aerobic exercise (65%). 5 key findings →
Design: meta-analysis Participants: 1,145 Evidence: high
Full summary, score breakdown and related studies → Original source
28 studies (total n = 1337 participants, average age 79-90 years) were included in the systematic review, of which 21 could be meta-analyzed. 4 key findings →
Design: systematic review Participants: 1,337 Evidence: high
Full summary, score breakdown and related studies → Original source
Our findings indicate that high-speed resistance exercise training approaches are effective in improving cognitive function and physical performance in older adults with cognitive frailty. 3 key findings →
Design: randomized controlled trial Participants: 30 Evidence: high
Full summary, score breakdown and related studies → Original source
The present study will address several shortcomings of previous CCT studies. 5 key findings →
Design: randomized controlled trial Participants: 162 Evidence: high
Full summary, score breakdown and related studies → Original source
79/100
The purpose of this study was to examine the effects of a 6-month cycling aerobic exercise intervention on cardiorespiratory fitness and the dose-response relationship in community-dwelling older adults with mild-to-moderate Alzheimer's dementia. 3 key findings →
Design: randomized controlled trial Participants: 16 Evidence: high
Full summary, score breakdown and related studies → Original source
In this study, NPTs have excellent potential to improve cognition in people with dementia, and PBM may have more significant benefits in improving cognition than the other four NPTs. 5 key findings →
Design: systematic review Participants: 38 Evidence: high
Full summary, score breakdown and related studies → Original source
The use of ecologically oriented approaches with virtual reality (VR) depicting instrumental activities of daily living (IADL) is a promising approach for interventions on acquired brain injuries. 2 key findings →
Design: randomized controlled trial Participants: 17 Evidence: high
Full summary, score breakdown and related studies → Original source
A growing number of investigations are exploring the utility of intranasal insulin as a means of mitigating cognitive decline. 2 key findings →
Evidence: high
Full summary, score breakdown and related studies → Original source
111,485 articles were initially retrieved; 288 full articles were reviewed and 89.6% subsequently deemed ineligible due to exclusion of participants with co-existence of dementia and Parkinsonism. 5 key findings →
Design: randomized controlled trial Participants: 16 Evidence: high
Full summary, score breakdown and related studies → Original source
This review aimed to evaluate the effects of multi-domain interventions on cognition among individuals without dementia. 1 key finding →
Participants: 10,056 Evidence: low
Full summary, score breakdown and related studies → Original source
Cognitive-motor dual-task training was more beneficial than single-task training alone in improving broader domains of cognitive functions of elderly persons, and the improvement was not directly due to modulating Aβ metabolism. 4 key findings →
Participants: 27 Evidence: high
Full summary, score breakdown and related studies → Original source
A long-term CMI in ChEI-treated early Alzheimer disease patients produced additional mood and cognitive benefits. 1 key finding →
Evidence: high
Full summary, score breakdown and related studies → Original source
Exercise training increases fitness, physical function, cognitive function, and positive behavior in people with dementia and related cognitive impairments. 3 key findings →
Design: meta-analysis Participants: 2,020 Evidence: high
Full summary, score breakdown and related studies → Original source
There is very limited evidence that exercise improves cognitive function in individuals with MCI, although published research is of moderate quality and inconclusive due to low statistical power. 5 key findings →
Design: meta-analysis Participants: 1,695 Evidence: high
Full summary, score breakdown and related studies → Original source
Randomized control intervention. 2 key findings →
Evidence: high
Full summary, score breakdown and related studies → Original source
Compared with UC, CCT increased scores on the MDRS's total, attention, and memory and those on the Mini-Mental State Examination and Telephone Interview of Cognitive Status over the 6-month intervention; TC increased scores on the MDRS's total and conceptualization and those on the Mini-Mental State Examination over the 6-month intervention, while it also increased scores on the MDRS's total and initiation/preservation and those on the Telephone Interview of Cognitive Status and reduced the time to complete the Trail Making Test B over the 12-month study. 3 key findings →
Design: randomized controlled trial Evidence: high
Full summary, score breakdown and related studies → Original source
Several animal studies have showed the beneficial effects of physical exercise (PE) on brain function and health. 2 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
Longitudinal observational studies show an association between higher levels of physical activity and a reduced risk of cognitive decline and dementia. 4 key findings →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
This is the first randomized controlled trial with supervised moderate-to-high intensity exercise in patients with mild AD. 4 key findings →
Design: randomized controlled trial Participants: 200 Evidence: high
Full summary, score breakdown and related studies → Original source
72/100
There has been growing evidence showing gait variability provides unique information about gait characteristics in neurological disorders. 1 key finding →
Design: meta-analysis Participants: 777 Evidence: high
Full summary, score breakdown and related studies → Original source
Exercise training is an important strategy to counteract cognitive and brain health decline during aging. 1 key finding →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
White matter deterioration is associated with cognitive impairment in healthy aging and Alzheimer's disease. 3 key findings →
Participants: 180 Evidence: low
Full summary, score breakdown and related studies → Original source
70/100
After 12 weeks, maintenance of executive functioning in the TG was found, yet no significant changes on circulating neurotrophins levels were identified. 3 key findings →
Participants: 16 Evidence: low
Full summary, score breakdown and related studies → Original source
From across this tag
8 of the 125 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.
- Physical activity interventions in older adults with a cognitive impairment: A critical review of reviews
- Physical Inactivity is Liable to the Increased Cardiovascular Risk and Impaired Cognitive Profile
- Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease
- Six-month walking program changes cognitive and ADL performance in patients with Alzheimer
- Effects of Physical Activity on Brain Energy Biomarkers in Alzheimer's Diseases
- Physical activity and Alzheimer's disease: from prevention to therapeutic perspectives
- Routine Assessment and Promotion of Physical Activity in Healthcare Settings: A Scientific Statement From the American Heart Association
- Motor function deficits in the 12 month-old female 5xFAD mouse model of Alzheimer's disease
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →