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Regulating factors for microglial activation
Nakamura Y.. Biological & pharmaceutical bulletin, 2002-08-01
Topic: Brain proteins, microglia and lab models
Microglia, residential macrophages in the central nervous system, can release a variety of factors including cytokines, chemokines, etc. to regulate the communication among neuronal and other types of glial cells. Microglia play immunological roles in mechanisms underlying the phagocytosis of invading microorganisms and removal of dead or damaged cells. When microglia are hyperactivated due to a certain pathological imbalance, they may cause neuronal degeneration.
Key findings
- Microglia play immunological roles in mechanisms underlying the phagocytosis of invading microorganisms and removal of dead or damaged cells.
- When microglia are hyperactivated due to a certain pathological imbalance, they may cause neuronal degeneration.
- Pathological activation of microglia has been reported in a wide range of conditions such as cerebral ischemia, Alzheimer's disease, prion diseases, multiple sclerosis, AIDS dementia, and others.
- Nearly 5000 papers on microglia can be retrieved on the Web site PubMed at present (November 2001) and half of them were published within the past 5 years.
Why it matters
This review notes that hyperactivated microglia may cause neuronal degeneration and that pathological microglial activation has been reported in Alzheimer's disease. It does not report any treatment, cure, or prevention tested in patients.
Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Biological & pharmaceutical bulletin) |
| Journal's citation record | 2 / 4 | Biological and Pharmaceutical Bulletin: journal h-index 155 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2002 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 240 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 9.2 citations a year over 26 year(s) since 2002 |
| Impact for its field and year | 3 / 6 | Cited 7.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 1 / 4 | Cited 11 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Yoichi Nakamura: h-index 47 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Osaka Prefecture University: institution h-index 376 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 12186424) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1248/bpb.25.945
- PubMed: 12186424
- Original source →
- Free full text: Biological and Pharmaceutical Bulletin →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Nakamura, Y. (2002). Regulating factors for microglial activation. Biological & pharmaceutical bulletin. https://doi.org/10.1248/bpb.25.945
Vancouver
Nakamura Y. Regulating factors for microglial activation. Biological & pharmaceutical bulletin. 2002. doi:10.1248/bpb.25.945. PMID: 12186424.
BibTeX
@article{nakamura2002-12186424,
author = {Nakamura, Y.},
title = {{Regulating factors for microglial activation}},
journal = {Biological \& pharmaceutical bulletin},
year = {2002},
doi = {10.1248/bpb.25.945},
pmid = {12186424},
url = {https://doi.org/10.1248/bpb.25.945}
}
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Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
3 studies in the alzhub library list this one in their references.