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Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
Duda JE, Giasson BI, Mabon ME, Lee VM, Trojanowski JQ.. Annals of neurology, 2002-08-01
Topic: Brain proteins, microglia and lab models
Plain-language summary
Intracytoplasmic inclusions composed of alpha-synuclein (alpha-syn) are characteristic of neurodegenerative Lewy body disorders. Using novel monoclonal antibodies raised against altered alpha-syn, we uncovered an unprecedented and extensive burden of alpha-syn pathology in the striatum of Lewy body disorders. The highest density of striatal pathology was observed in patients with a combination of Alzheimer's disease and dementia with Lewy bodies or pure dementia with Lewy bodies, and these alpha-syn aggregates may contribute to the parkinsonism seen in these disorders.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Duda, J. E., Giasson, B. I., Mabon, M. E., Lee, V. M., & Trojanowski, J. Q. (2002). Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Annals of neurology. https://doi.org/10.1002/ana.10279
Vancouver
Duda JE, Giasson BI, Mabon ME, Lee VM, Trojanowski JQ. Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Annals of neurology. 2002. doi:10.1002/ana.10279. PMID: 12210791.
BibTeX
@article{duda2002-12210791,
author = {Duda, J. E. and Giasson, B. I. and Mabon, M. E. and Lee, V. M. and Trojanowski, J. Q.},
title = {{Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases}},
journal = {Annals of neurology},
year = {2002},
doi = {10.1002/ana.10279},
pmid = {12210791},
url = {https://doi.org/10.1002/ana.10279}
}
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Key findings
- Intracytoplasmic inclusions composed of alpha-synuclein (alpha-syn) are characteristic of neurodegenerative Lewy body disorders.
- Using novel monoclonal antibodies raised against altered alpha-syn, we uncovered an unprecedented and extensive burden of alpha-syn pathology in the striatum of Lewy body disorders.
- The highest density of striatal pathology was observed in patients with a combination of Alzheimer's disease and dementia with Lewy bodies or pure dementia with Lewy bodies, and these alpha-syn aggregates may contribute to the parkinsonism seen in these disorders.
Why it matters
Using newly developed antibodies against altered alpha-synuclein, this 2002 brain-tissue study reported an "unprecedented and extensive" build-up of alpha-synuclein in the striatum (a movement-related brain region) in Lewy body diseases, densest in people with pure dementia with Lewy bodies or Alzheimer's combined with dementia with Lewy bodies. The authors suggest these deposits "may contribute" to the parkinsonism (stiffness, slowness) seen in these conditions; this is a proposed link, not a proven cause. It is a laboratory finding and tested no treatment.
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Study details
- Evidence strengthLow
How this study scored 50/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | 3 / 4 | Annals of Neurology: journal h-index 437 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2002 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 330 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 12.7 citations a year over 26 year(s) since 2002 |
| Impact for its field and year | 4 / 6 | Cited 13.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 19 other studies in this library |
| Still being cited | 1 / 4 | Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author John Q. Trojanowski: h-index 255 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Pennsylvania: institution h-index 1,859 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 12210791) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
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