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Decreased cerebrospinal fluid acetylcholinesterase in patients with subcortical ischemic vascular dementia
Anders Wallin, Magnus Sjögren, Kaj Blennow, Pia Davidsson. Dementia and geriatric cognitive disorders, 2003
Topic: Plasma and spinal-fluid biomarkers
Plain-language summary
The main objective was to investigate the acetylcholinesterase E (AChE) activity in the cerebrospinal fluid (CSF) of patients with three common dementia disorders. We also wanted to investigate the influence of apolipoprotein E (ApoE) epsilon4 allele possession and CSF-tau level on the CSF-AChE activity in these patients. The study included 17 consecutive patients with subcortical vascular dementia (SVD), 39 with Alzheimer's disease (AD), 14 with frontotemporal dementia (FTD) and 12 controls. CSF was obtained by lumbar puncture and CSF-AChE activity was measured by an enzyme antigen immunoassay. CSF-AchE activity was significantly decreased compared to controls only in the SVD group (p = 0.010). The CSF-tau level was increased in the AD group compared to the control (p < 0.01) and FTD groups (p < 0.05). No influence of ApoE epsilon4 allele possession on CSF-AChE activity was found. It is suggested that abnormal CSF-AChE activity in patients with SVD reflects a disturbance in the cholinergic system.
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APA 7th
Wallin, A., Sjögren, M., Blennow, K., & Davidsson, P. (2003). Decreased cerebrospinal fluid acetylcholinesterase in patients with subcortical ischemic vascular dementia. Dementia and geriatric cognitive disorders. https://doi.org/10.1159/000072803
Vancouver
Wallin A, Sjögren M, Blennow K, Davidsson P. Decreased cerebrospinal fluid acetylcholinesterase in patients with subcortical ischemic vascular dementia. Dementia and geriatric cognitive disorders. 2003. doi:10.1159/000072803. PMID: 14512714.
BibTeX
@article{wallin2003-14512714,
author = {Wallin, Anders and Sjögren, Magnus and Blennow, Kaj and Davidsson, Pia},
title = {{Decreased cerebrospinal fluid acetylcholinesterase in patients with subcortical ischemic vascular dementia}},
journal = {Dementia and geriatric cognitive disorders},
year = {2003},
doi = {10.1159/000072803},
pmid = {14512714},
url = {https://doi.org/10.1159/000072803}
}
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Key findings
- CSF-AchE activity was significantly decreased compared to controls only in the SVD group (p = 0.010).
- The CSF-tau level was increased in the AD group compared to the control (p < 0.01) and FTD groups (p < 0.05).
- It is suggested that abnormal CSF-AChE activity in patients with SVD reflects a disturbance in the cholinergic system.
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Study details
- Participants17
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 25 of the 56 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Dementia and geriatric cognitive disorders) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2003 — older than 20 years, still counted |
| Sample size | 1 / 4 | 17 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 14512714) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 25 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 25 of the 56 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
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