Investigating the effects of complement loci CFH and ARMS2/HTRA1 on Alzheimer Disease
Noel C. Moore, Yeunjoo E. Song, Alex V. Gulyayev, Kristy L. S. Miskimen, Reneé A. Laux, Audrey H. Lynn, Sarada L. Fuzzell, Sherri D. Hochstetler et al.. Alzheimer s & Dementia, 2025-12-01
Topic: Brain proteins, microglia and lab models
Our preliminary results found no significant association between LOAD and the individual SNPs defining the CFH or ARMS2/HTRA1 loci. As these genes are in regions of strong linkage disequilibrium, these SNPs define a small set of extended haplotypes, which have known differential impact on AMD. Single SNP association analyses did not expose any significant associations between LOAD and single SNPs at the CFH or ARMS2/HTRA1 loci. Examining the haplotype association with LOAD will allow for increased power and better understanding of the risk these two loci confer to LOAD.
Key findings
- Our preliminary results found no significant association between LOAD and the individual SNPs defining the CFH or ARMS2/HTRA1 loci.
- As these genes are in regions of strong linkage disequilibrium, these SNPs define a small set of extended haplotypes, which have known differential impact on AMD.
- Single SNP association analyses did not expose any significant associations between LOAD and single SNPs at the CFH or ARMS2/HTRA1 loci.
- Examining the haplotype association with LOAD will allow for increased power and better understanding of the risk these two loci confer to LOAD.
Why it matters
Preliminary results found no significant association between late-onset Alzheimer's disease and individual SNPs at the CFH or ARMS2/HTRA1 loci. Examining haplotypes may provide more power to understand the risk these loci confer.
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Study details
- Participants152
- Evidence strengthLow
How this study scored 37/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 152 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 0 / 4 | Last-listed author Jonathan L Haines: h-index 1 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, Los Angeles: institution h-index 1,923 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41439341) |
| Free to read | 2 / 2 | Free to read |
| Total | 37 / 100 | — |
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Read the original
- DOI: 10.1002/alz70855_106578
- PubMed: 41439341
- Original source →
- Free full text: Alzheimer s & Dementia →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Moore, N. C., Song, Y. E., Gulyayev, A. V., Miskimen, K. L. S., Laux, R. A., Lynn, A. H., et al. (2025). Investigating the effects of complement loci CFH and ARMS2/HTRA1 on Alzheimer Disease. Alzheimer s & Dementia. https://doi.org/10.1002/alz70855_106578
Vancouver
Moore NC, Song YE, Gulyayev AV, Miskimen KLS, Laux RA, Lynn AH, et al. Investigating the effects of complement loci CFH and ARMS2/HTRA1 on Alzheimer Disease. Alzheimer s & Dementia. 2025. doi:10.1002/alz70855_106578. PMID: 41439341.
BibTeX
@article{moore2025-41439341,
author = {Moore, Noel C. and Song, Yeunjoo E. and Gulyayev, Alex V. and Miskimen, Kristy L. S. and Laux, Reneé A. and Lynn, Audrey H. and Fuzzell, Sarada L. and Hochstetler, Sherri D. and others},
title = {{Investigating the effects of complement loci CFH and ARMS2/HTRA1 on Alzheimer Disease}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz70855_106578},
pmid = {41439341},
url = {https://doi.org/10.1002/alz70855_106578}
}
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