Topic: Amyloid, tau and blood-test diagnosis
Our findings highlight the potential of diverse genomic backgrounds to uncover protective genetic factors, such as the African-specific protective PSG2 locus, found to confer a protective effect among APOE4 carriers.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Rajabli, F., Alzheimer's Disease Sequencing Project, & Griswold, A. J. (2025). Leveraging African Ancestry Diversity for Global Advances in Alzheimer Disease Genetics. Alzheimer s & Dementia. https://doi.org/10.1002/alz70855_105506
Vancouver
Rajabli F, Alzheimer's Disease Sequencing Project, Griswold AJ. Leveraging African Ancestry Diversity for Global Advances in Alzheimer Disease Genetics. Alzheimer s & Dementia. 2025. doi:10.1002/alz70855_105506. PMID: 41442731.
BibTeX
@article{rajabli2025-41442731,
author = {Rajabli, Farid and {Alzheimer's Disease Sequencing Project} and Griswold, Anthony J.},
title = {{Leveraging African Ancestry Diversity for Global Advances in Alzheimer Disease Genetics}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz70855_105506},
pmid = {41442731},
url = {https://doi.org/10.1002/alz70855_105506}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Our findings highlight the potential of diverse genomic backgrounds to uncover protective genetic factors, such as the African-specific protective PSG2 locus, found to confer a protective effect among APOE4 carriers.
Why it matters
Diverse genomic backgrounds can uncover protective genetic factors, such as the African-specific PSG2 locus that confers protection among APOE4 carriers. This highlights the potential of African ancestry diversity for global advances in Alzheimer's genetics.
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Study details
- Evidence strengthLow
How this study scored 33/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Anthony J. Griswold: h-index 26 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Pennsylvania: institution h-index 1,859 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41442731) |
| Free to read | 2 / 2 | Free to read |
| Total | 33 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1002/alz70855_105506
- PubMed: 41442731
- Original source →
- Free full text: Alzheimer s & Dementia →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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