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39/100

✓ Peer-reviewed alzhub usefulness score 39 out of 100. Brain scans and imaging

Topic: Amyloid, tau and blood-test diagnosis

Plain-language summary

Objective Correlations between corpus callosum size and interhemispheric EEG coherence were investigated as measures of interhemispheric connectivity in patients with Alzheimer's disease. Methods 11 patients underwent both magnetic resonance imaging and quantitative electroencephalography to assess corpus callosum size and interhemispheric coherence. For comparison, corpus callosum size was measured in 24 healthy elderly control subjects. Results Corpus callosum cross sectional area was significantly reduced in Alzheimer patients relative to controls. Posterior interhemispheric coherence (alpha and beta frequencies) correlated significantly with the size of posterior corpus callosum area, and anterior coherence (delta, theta, and alpha frequencies) with the size of anterior corpus callosum area in the Alzheimer patients. Conclusion Region specific correlations between corpus callosum size and EEG coherence suggest that the decline in interhemispheric connectivity in Alzheimer's disease results from a specific loss of cortical association neurones projecting through the corpus callosum.

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APA 7th

Pogarell, O., Teipel, S. J., Juckel, G., Gootjes, L., Möller, T., Bürger, K., et al. (2005). EEG coherence reflects regional corpus callosum area in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. https://doi.org/10.1136/jnnp.2004.036566

Vancouver

Pogarell O, Teipel SJ, Juckel G, Gootjes L, Möller T, Bürger K, et al. EEG coherence reflects regional corpus callosum area in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. 2005. doi:10.1136/jnnp.2004.036566. PMID: 15608007.

BibTeX

@article{pogarell2005-15608007,
  author  = {Pogarell, O. and Teipel, S. J. and Juckel, G. and Gootjes, L. and Möller, T. and Bürger, K. and Leinsinger, G. and Möller, H. J. and others},
  title   = {{EEG coherence reflects regional corpus callosum area in Alzheimer's disease}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2005},
  doi     = {10.1136/jnnp.2004.036566},
  pmid    = {15608007},
  url     = {https://doi.org/10.1136/jnnp.2004.036566}
}

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How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
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Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

Results Corpus callosum cross sectional area was significantly reduced in Alzheimer patients relative to controls.
Posterior interhemispheric coherence (alpha and beta frequencies) correlated significantly with the size of posterior corpus callosum area, and anterior coherence (delta, theta, and alpha frequencies) with the size of anterior corpus callosum area in the Alzheimer patients.
Conclusion Region specific correlations between corpus callosum size and EEG coherence suggest that the decline in interhemispheric connectivity in Alzheimer's disease results from a specific loss of cortical association neurones projecting through the corpus callosum.

Why it matters

In this small study of 11 patients, corpus callosum size was reduced in Alzheimer's disease and correlated with interhemispheric EEG coherence. It is about understanding brain connectivity changes, not about a treatment, cure or prevention.

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Study details

Evidence strengthLow

How this study scored 39/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of neurology, neurosurgery, and psychiatry)
Journal's citation record	3 / 4	Journal of Neurology Neurosurgery & Psychiatry: journal h-index 336 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2005 — older than 20 years, still counted
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 82 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	3.6 citations a year over 23 year(s) since 2005
Impact for its field and year	2 / 6	Cited 1.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 3 other studies in this library
Still being cited	1 / 4	Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Oliver Michael Pogarell: h-index 57 (OpenAlex, whole career)
Institution's track record	1 / 3	Ludwig-Maximilians-Universität München: institution h-index 1,224 (OpenAlex)
Multicenter collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 15608007)
Free to read	0 / 2	Behind a paywall — scores zero
Total	39 / 100	—

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