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Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat
Wang XC, Zhang J, Yu X, Han L, Zhou ZT, Zhang Y, Wang JZ.. Sheng li xue bao : [Acta physiologica Sinica], 2005-02-01
Topic: Brain proteins, microglia and lab models
Hyperphosphorylated microtubule-associated protein tau is the major protein component of neurofibrillary tangles in the brain of patients with Alzheimer's disease (AD). Until now, there is no effective cure to arrest this hyperphosphorylation. The present study was designed to explore the in vivo preventive effect of melatonin on Alzheimer-like tau hyperphosphorylation.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wang, X. C., Zhang, J., Yu, X., Han, L., Zhou, Z. T., Zhang, Y., et al. (2005). Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat. Sheng li xue bao : [Acta physiologica Sinica].
Vancouver
Wang XC, Zhang J, Yu X, Han L, Zhou ZT, Zhang Y, et al. Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat. Sheng li xue bao : [Acta physiologica Sinica]. 2005. PMID: 15719129.
BibTeX
@article{wang2005-15719129,
author = {Wang, X. C. and Zhang, J. and Yu, X. and Han, L. and Zhou, Z. T. and Zhang, Y. and Wang, J. Z.},
title = {{Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat}},
journal = {Sheng li xue bao : [Acta physiologica Sinica]},
year = {2005},
pmid = {15719129}
}
Built from the record alzhub holds for this paper, not looked up. This record has no DOI, so the citation leaves it out. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Until now, there is no effective cure to arrest this hyperphosphorylation.
- The present study was designed to explore the in vivo preventive effect of melatonin on Alzheimer-like tau hyperphosphorylation.
- Isoproterenol, a beta-receptor agonist, was used to induce tau hyperphosphorylation, and for preventive effect of melatonin, the rats were injected intraperitoneally with melatonin for 5 d before hippocampi infusion of isoproterenol.
- The level of tau phosphorylation was detected by Western blot and immunohistochemistry using sites specific antibodies (PHF-1 and Tau-1), and it was normalized by non-phosphorylation dependent total tau antibody (111e).
Why it matters
In rats, melatonin was tested for its ability to prevent tau hyperphosphorylation induced by isoproterenol. This is an animal study of a prevention approach, and the text states there is currently no effective cure to arrest this hyperphosphorylation.
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Study details
- Evidence strengthLow
How this study scored 34/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, so that was left out: it earned 33 of the 96 points we could judge it on, which is 34 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Sheng li xue bao : [Acta physiologica Sinica]) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “rat”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 50 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.2 citations a year over 23 year(s) since 2005 |
| Impact for its field and year | 1 / 6 | Cited 0.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Jian‐Zhi Wang: h-index 58 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Huazhong University of Science and Technology: institution h-index 934 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15719129) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 33 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 33 of the 96 points we could judge it on is 34 out of 100. |
| Total | 34 / 100 | — |
What each of these 20 components measures, and what this score is not →
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