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A prospective longitudinal study of apathy in Alzheimer's disease
SERGIO E. STARKSTEIN. Journal of Neurology Neurosurgery & Psychiatry, 2005-12-16
Topic: Brain imaging, connectivity and assessment
Plain-language summary
Apathy was significantly associated with older age (p = 0.009), and a higher frequency of minor and major depression (p < 0.0001). Apathy at baseline was a significant predictor of depression at follow up (p = 0.01), and was associated with a faster cognitive (p = 0.0007) and functional decline (p = 0.006). Apathy in AD is a behavioural marker of a more aggressive dementia, characterised by a faster progression of cognitive, functional, and emotional impairment.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
STARKSTEIN, S. E. (2005). A prospective longitudinal study of apathy in Alzheimer's disease. Journal of Neurology Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp.2005.069575
Vancouver
STARKSTEIN SE. A prospective longitudinal study of apathy in Alzheimer's disease. Journal of Neurology Neurosurgery & Psychiatry. 2005. doi:10.1136/jnnp.2005.069575. PMID: 16361584.
BibTeX
@article{starkstein2005-16361584,
author = {STARKSTEIN, SERGIO E.},
title = {{A prospective longitudinal study of apathy in Alzheimer's disease}},
journal = {Journal of Neurology Neurosurgery \& Psychiatry},
year = {2005},
doi = {10.1136/jnnp.2005.069575},
pmid = {16361584},
url = {https://doi.org/10.1136/jnnp.2005.069575}
}
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Key findings
- Apathy was significantly associated with older age (p = 0.009), and a higher frequency of minor and major depression (p < 0.0001).
- Apathy at baseline was a significant predictor of depression at follow up (p = 0.01), and was associated with a faster cognitive (p = 0.0007) and functional decline (p = 0.006).
- Apathy in AD is a behavioural marker of a more aggressive dementia, characterised by a faster progression of cognitive, functional, and emotional impairment.
Study details
- Participants354
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 28 of the 58 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Neurology Neurosurgery & Psychiatry) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 2 / 4 | 354 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16361584) |
| Free to read | 2 / 2 | Free to read |
| Points | 28 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 28 of the 58 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
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