Apolipoprotein E and dementia in Parkinson disease: a meta-analysis
Huang X, Chen P, Kaufer DI, Tröster AI, Poole C.. Archives of neurology, 2006-02-01
Topic: Amyloid, tau and blood-test diagnosis
Objective To understand the relationship of apolipoprotein E (APOE) polymorphism to dementia in Parkinson disease (PD) because the APOE epsilon4 allele is linked to Alzheimer disease. Data source We reviewed MEDLINE, BIOSIS Previews, and ISI Web of Science from January 1, 1966, to May 7, 2004, supplemented by citation analysis from retrieved articles. Study selection Case-control studies using clinical or pathologic criteria for PD and dementia, and with complete APOE genotype frequencies data. Data extraction We compared estimated prevalence odds ratios for dementia in PD in relation to each allele. We also looked for evidence of heterogeneity and publication bias and performed a stratified analysis on several study characteristics. Data synthesis Data analyses suggest publication bias and heterogeneity of source data for the epsilon4 allele (homogeneity P = .2; Begg and Mazumdar, P = .06; and Egger et al, P = .1). The estimated odds ratios for development of dementia in PD are 1.6 for epsilon4 (95% confidence interval, 1.0-2.5); 1.3 for epsilon2 (95% confidence interval, 0.73-2.4); and 0.54 for epsilon3 (95% confidence interval, 0.18-1.6). The odds ratio estimates for epsilon4 were higher for studies published in 1996 or later (2.3 vs 1.0) and for studies conducted outside North American sites (2.4 vs 1.2). Conclusions The APOE epsilon4 allele appears to be associated with a higher prevalence of dementia in PD. Publication bias and heterogeneous source data may, however, confound this conclusion. Confirmatory studies that use standardized and validated diagnostic criteria for dementia in PD are needed.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Huang, X., Chen, P., Kaufer, D. I., Tröster, A. I., & Poole, C. (2006). Apolipoprotein E and dementia in Parkinson disease: a meta-analysis. Archives of neurology. https://doi.org/10.1001/archneur.63.2.189
Vancouver
Huang X, Chen P, Kaufer DI, Tröster AI, Poole C. Apolipoprotein E and dementia in Parkinson disease: a meta-analysis. Archives of neurology. 2006. doi:10.1001/archneur.63.2.189. PMID: 16476806.
BibTeX
@article{huang2006-16476806,
author = {Huang, X. and Chen, P. and Kaufer, D. I. and Tröster, A. I. and Poole, C.},
title = {{Apolipoprotein E and dementia in Parkinson disease: a meta-analysis}},
journal = {Archives of neurology},
year = {2006},
doi = {10.1001/archneur.63.2.189},
pmid = {16476806},
url = {https://doi.org/10.1001/archneur.63.2.189}
}
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Key findings
- Conclusions The APOE epsilon4 allele appears to be associated with a higher prevalence of dementia in PD.
Why it matters
This meta-analysis of case-control studies found that the APOE4 allele appears to be associated with a higher prevalence of dementia in Parkinson disease. The authors note publication bias and heterogeneity in the source data, so the finding should be interpreted with caution.
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Study details
- Study designcase-control study
- Evidence strengthModerate
How this study scored 56/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for sample size, effect reported and studied in people because the record does not state it. We have no data on journal's citation record, so that was left out: it earned 54 of the 96 points we could judge it on, which is 56 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A meta-analysis pooling many studies (from PubMed type “Meta-Analysis”) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | 5 / 7 | Cited 130 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.9 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 3 / 6 | Cited 5.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 10 other studies in this library |
| Still being cited | 1 / 4 | Cited 13 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Charles Poole: h-index 64 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of North Carolina at Chapel Hill: institution h-index 1,674 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16476806) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 54 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 54 of the 96 points we could judge it on is 56 out of 100. |
| Total | 56 / 100 | — |
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