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Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease
Iseri PK, Altinaş O, Tokay T, Yüksel N.. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2006-03-01
Topic: Brain imaging, connectivity and assessment
Background There is conflicting evidence as to whether Alzheimer disease (AD) is accompanied by loss of retinal ganglion cells. To evaluate this issue, we have used optical coherence tomography (OCT) to assess the thickness and volume of the retina. We have also sought to correlate our findings with visual function and cognitive impairment. Methods We evaluated 28 eyes of 14 patients with AD and 30 eyes of 15 age-matched control subjects. In these two groups, we measured retinal nerve fiber layer (RNFL) thickness, macular thickness, and macular volume with OCT, visual function through latency of the pattern visual evoked potential (VEP) signal, and cognitive impairment through the Mini-Mental State Examination (MMSE). Results The parapapillary and macular RNFL thickness in all quadrants and positions of AD patients were thinner than in control subjects. The mean total macular volume of AD patients was significantly reduced as compared with control subjects (P < 0.05). Total macular volume and MMSE scores were significantly correlated. No significant difference was found in the latency of the VEP P100 of AD patients and control subjects. Conclusions Our study confirms some other studies in showing that in AD patients there is a reduction of parapapillary and macular RNFL thickness and macular volume as measured by OCT. The reduction in macular volume was related to the severity of cognitive impairment.
Key findings
- We have also sought to correlate our findings with visual function and cognitive impairment.
- Results The parapapillary and macular RNFL thickness in all quadrants and positions of AD patients were thinner than in control subjects.
- The mean total macular volume of AD patients was significantly reduced as compared with control subjects (P < 0.05).
- Total macular volume and MMSE scores were significantly correlated.
- No significant difference was found in the latency of the VEP P100 of AD patients and control subjects.
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Study details
- Participants14
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 25 of the 58 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 1 / 4 | 14 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16518161) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 25 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 25 of the 58 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Iseri, P. K., Altinaş, O., Tokay, T., & Yüksel, N. (2006). Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. https://doi.org/10.1097/01.wno.0000204645.56873.26
Vancouver
Iseri PK, Altinaş O, Tokay T, Yüksel N. Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 2006. doi:10.1097/01.wno.0000204645.56873.26. PMID: 16518161.
BibTeX
@article{iseri2006-16518161,
author = {Iseri, P. K. and Altinaş, O. and Tokay, T. and Yüksel, N.},
title = {{Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease}},
journal = {Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society},
year = {2006},
doi = {10.1097/01.wno.0000204645.56873.26},
pmid = {16518161},
url = {https://doi.org/10.1097/01.wno.0000204645.56873.26}
}
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