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Cutting Edge: TREM-2 Attenuates Macrophage Activation
Isaiah R. Turnbull, Susan Gilfillan, Marina Cella, Taiki Aoshi, Mark J. Miller, Laura M. Piccio, Maristela Hernandez, Marco Colonna. The Journal of Immunology, 2006-09-01
Topic: Brain proteins, microglia and lab models
The triggering receptor expressed on myeloid cells 2 (TREM-2) delivers intracellular signals through the adaptor DAP12 to regulate myeloid cell function both within and outside the immune system. The role of TREM-2 in immunity has been obscured by the failure to detect expression of the TREM-2 protein in vivo. In this study, we show that TREM-2 is expressed on macrophages infiltrating the tissues from the circulation and that alternative activation with IL-4 can induce TREM-2. TREM-2 expression is abrogated by macrophage maturation with LPS of IFN-gamma. Using TREM-2(-/-) mice, we find that TREM-2 functions to inhibit cytokine production by macrophages in response to the TLR ligands LPS, zymosan, and CpG. Furthermore, we find that TREM-2 completely accounts for the increased cytokine production previously reported by DAP12(-/-) macrophages. Taken together, these data show that TREM-2 is expressed on newly differentiated and alternatively activated macrophages and functions to restrain macrophage activation.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Turnbull, I. R., Gilfillan, S., Cella, M., Aoshi, T., Miller, M. J., Piccio, L. M., et al. (2006). Cutting Edge: TREM-2 Attenuates Macrophage Activation. The Journal of Immunology. https://doi.org/10.4049/jimmunol.177.6.3520
Vancouver
Turnbull IR, Gilfillan S, Cella M, Aoshi T, Miller MJ, Piccio LM, et al. Cutting Edge: TREM-2 Attenuates Macrophage Activation. The Journal of Immunology. 2006. doi:10.4049/jimmunol.177.6.3520. PMID: 16951310.
BibTeX
@article{turnbull2006-16951310,
author = {Turnbull, Isaiah R. and Gilfillan, Susan and Cella, Marina and Aoshi, Taiki and Miller, Mark J. and Piccio, Laura M. and Hernandez, Maristela and Colonna, Marco},
title = {{Cutting Edge: TREM-2 Attenuates Macrophage Activation}},
journal = {The Journal of Immunology},
year = {2006},
doi = {10.4049/jimmunol.177.6.3520},
pmid = {16951310},
url = {https://doi.org/10.4049/jimmunol.177.6.3520}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Taken together, these data show that TREM-2 is expressed on newly differentiated and alternatively activated macrophages and functions to restrain macrophage activation.
Why it matters
This study in mice found that TREM-2 is expressed on macrophages and functions to restrain macrophage activation. It is an animal study and does not directly address treating, curing, or preventing Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 53/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The Journal of Immunology) |
| Journal's citation record | 4 / 4 | The Journal of Immunology: journal h-index 531 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 691 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 31.4 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 4 / 6 | Cited 8.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 5 / 6 | Cited by 137 other studies in this library |
| Still being cited | 3 / 4 | Cited 128 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Marco Colonna: h-index 172 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16951310) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 53 / 100 | — |
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Also tagged “macrophages”
363 studies in the library carry the topic tag “macrophages”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 363 tagged studies.