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The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening
Mioshi E, Dawson K, Mitchell J, Arnold R, Hodges JR.. International journal of geriatric psychiatry, 2006-11-01
Topic: Amyloid, tau and blood-test diagnosis
Unlabelled There is a clear need for brief, but sensitive and specific, cognitive screening instruments as evidenced by the popularity of the Addenbrooke's Cognitive Examination (ACE). Objectives We aimed to validate an improved revision (the ACE-R) which incorporates five sub-domain scores (orientation/attention, memory, verbal fluency, language and visuo-spatial). Methods Standard tests for evaluating dementia screening tests were applied. A total of 241 subjects participated in this study (Alzheimer's disease=67, frontotemporal dementia=55, dementia of Lewy Bodies=20; mild cognitive impairment-MCI=36; controls=63). Results Reliability of the ACE-R was very good (alpha coefficient=0.8). Correlation with the Clinical Dementia Scale was significant (r=-0.321, p Conclusions The ACE-R accomplishes standards of a valid dementia screening test, sensitive to early cognitive dysfunction.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Mioshi, E., Dawson, K., Mitchell, J., Arnold, R., & Hodges, JR. (2006). The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening. International journal of geriatric psychiatry. https://doi.org/10.1002/gps.1610
Vancouver
Mioshi E, Dawson K, Mitchell J, Arnold R, Hodges JR. The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening. International journal of geriatric psychiatry. 2006. doi:10.1002/gps.1610. PMID: 16977673.
BibTeX
@article{mioshi2006-16977673,
author = {Mioshi, E. and Dawson, K. and Mitchell, J. and Arnold, R. and Hodges, JR.},
title = {{The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening}},
journal = {International journal of geriatric psychiatry},
year = {2006},
doi = {10.1002/gps.1610},
pmid = {16977673},
url = {https://doi.org/10.1002/gps.1610}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Results Reliability of the ACE-R was very good (alpha coefficient=0.8).
- Correlation with the Clinical Dementia Scale was significant (r=-0.321, p Conclusions The ACE-R accomplishes standards of a valid dementia screening test, sensitive to early cognitive dysfunction.
Why it matters
This 2006 study tested a revised version of a short memory-and-thinking test, the ACE-R, which gives five sub-scores (orientation/attention, memory, verbal fluency, language and visuo-spatial), in 241 people with Alzheimer's, frontotemporal or Lewy body dementia, mild cognitive impairment, or no impairment. The authors report that the test was internally consistent (alpha 0.8) and correlated with a dementia rating scale (r = −0.321), and they conclude it meets the standards of a valid screening test that is "sensitive to early cognitive dysfunction". It is a screening tool that flags people for further assessment, not a diagnosis, and alzhub's stored abstract is cut off before the detailed accuracy figures, so check the original paper for cut-offs and accuracy.
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Study details
- Participants241
- Evidence strengthLow
How this study scored 59/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International journal of geriatric psychiatry) |
| Journal's citation record | 2 / 4 | International Journal of Geriatric Psychiatry: journal h-index 190 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 2 / 4 | 241 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 2,026 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 92.1 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 4 / 6 | Cited 10.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 40 other studies in this library |
| Still being cited | 4 / 4 | Cited 286 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author John R. Hodges: h-index 107 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Cambridge: institution h-index 1,973 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16977673) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 59 / 100 | — |
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