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The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease
Wilkinson BL, Landreth GE.. Journal of neuroinflammation, 2006-11-09
Topic: Brain proteins, microglia and lab models
Alzheimer's disease is the most common cause of dementia in the elderly, and manifests as progressive cognitive decline and profound neuronal loss. The principal neuropathological hallmarks of Alzheimer's disease are the senile plaques and the neurofibrillary tangles. The senile plaques are surrounded by activated microglia, which are largely responsible for the proinflammatory environment within the diseased brain.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wilkinson, B. L., & Landreth, G. E. (2006). The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease. Journal of neuroinflammation. https://doi.org/10.1186/1742-2094-3-30
Vancouver
Wilkinson BL, Landreth GE. The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease. Journal of neuroinflammation. 2006. doi:10.1186/1742-2094-3-30. PMID: 17094809.
BibTeX
@article{wilkinson2006-17094809,
author = {Wilkinson, B. L. and Landreth, G. E.},
title = {{The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease}},
journal = {Journal of neuroinflammation},
year = {2006},
doi = {10.1186/1742-2094-3-30},
pmid = {17094809},
url = {https://doi.org/10.1186/1742-2094-3-30}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- The principal neuropathological hallmarks of Alzheimer's disease are the senile plaques and the neurofibrillary tangles.
- The senile plaques are surrounded by activated microglia, which are largely responsible for the proinflammatory environment within the diseased brain.
- Microglia are the resident innate immune cells in the brain.
- In response to contact with fibrillar beta-amyloid, microglia secrete a diverse array of proinflammatory molecules.
Why it matters
This review describes how activated microglia around amyloid plaques produce proinflammatory molecules and that the microglial NADPH oxidase complex is a source of oxidative stress. It is a summary of mechanisms, not a clinical trial, so it offers no confirmed treatment, cure or prevention for Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neuroinflammation) |
| Journal's citation record | 2 / 4 | Journal of Neuroinflammation: journal h-index 216 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 232 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.5 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 3 / 6 | Cited 6.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 31 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Gary E. Landreth: h-index 101 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Case Western Reserve University: institution h-index 1,159 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17094809) |
| Free to read | 2 / 2 | Free to read |
| Total | 45 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/1742-2094-3-30
- PubMed: 17094809
- Original source →
- Free full text: Journal of Neuroinflammation →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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