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Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition
Parachikova A, Nichol KE, Cotman CW.. Neurobiology of disease, 2008-01-05
Topic: Brain proteins, microglia and lab models
Exercise is a treatment paradigm that can ameliorate cognitive dysfunction in Alzheimer disease (AD) and AD mouse models. Since exercise is also known to alter the peripheral immune response, one potential mechanism for the cognitive improvement following exercise may be by modulating the inflammatory repertoire in the central nervous system. We investigated the effects of voluntary exercise in the Tg2576 mouse model of AD at a time-point at which pathology has already developed.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Parachikova, A., Nichol, K. E., & Cotman, C. W. (2008). Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition. Neurobiology of disease. https://doi.org/10.1016/j.nbd.2007.12.008
Vancouver
Parachikova A, Nichol KE, Cotman CW. Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition. Neurobiology of disease. 2008. doi:10.1016/j.nbd.2007.12.008. PMID: 18258444.
BibTeX
@article{parachikova2008-18258444,
author = {Parachikova, A. and Nichol, K. E. and Cotman, C. W.},
title = {{Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition}},
journal = {Neurobiology of disease},
year = {2008},
doi = {10.1016/j.nbd.2007.12.008},
pmid = {18258444},
url = {https://doi.org/10.1016/j.nbd.2007.12.008}
}
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Key findings
- Since exercise is also known to alter the peripheral immune response, one potential mechanism for the cognitive improvement following exercise may be by modulating the inflammatory repertoire in the central nervous system.
- We investigated the effects of voluntary exercise in the Tg2576 mouse model of AD at a time-point at which pathology has already developed.
- Inflammatory mRNA markers are increased in sedentary Tg2576 mice versus non-transgenic controls.
- We demonstrate that short-term voluntary wheel running improved spatial learning in aged transgenic mice as compared to sedentary Tg2576 controls.
Why it matters
In aged Tg2576 mice with existing Alzheimer's-like pathology, short-term voluntary exercise improved cognition and altered neuroinflammation. Because this was done in mice, it does not establish that exercise produces the same cognitive benefit in people with Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of disease) |
| Journal's citation record | 2 / 4 | Neurobiology of Disease: journal h-index 225 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2008 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “tg2576”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 192 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 9.6 citations a year over 20 year(s) since 2008 |
| Impact for its field and year | 4 / 6 | Cited 8.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 1 / 4 | Cited 12 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Carl W. Cotman: h-index 166 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of California, Irvine: institution h-index 1,195 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 18258444) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
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