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56/100

✓ Peer-reviewed alzhub usefulness score 56 out of 100. Mild cognitive impairment

Topic: Brain proteins, microglia and lab models

Objective To use (18)F-fluorodeoxyglucose (FDG) and PET to investigate changes in regional metabolism associated with mild cognitive impairment (MCI) in Parkinson disease (PD). Cognitive abnormalities are common in PD. However, little is known about the functional abnormalities that underlie the manifestations of MCI in this disorder. Methods We used FDG PET to measure regional glucose metabolism in patients with PD with multiple-domain MCI (MD-MCI; n = 18), with single-domain MCI (SD-MCI; n = 15), and without MCI (N-MCI; n = 18). These patients were matched for age, education, disease duration, and motor disability. Maps of regional metabolism in the three groups were compared using statistical parametric mapping (SPM). We also computed the expression of a previously validated cognition-related spatial covariance pattern (PDCP) in the patient groups and in an age-matched healthy control cohort (n = 15). PDCP expression was compared across groups using analysis of variance. Results SPM revealed decreased prefrontal and parietal metabolism (p Conclusions Early cognitive decline in Parkinson disease as defined by mild cognitive impairment is associated with discrete regional changes and abnormal metabolic network activity. The quantification of these alterations with (18)F-fluorodeoxyglucose PET may allow for the objective assessment of the progression and treatment of this disease manifestation.

Key findings

Objective To use (18)F-fluorodeoxyglucose (FDG) and PET to investigate changes in regional metabolism associated with mild cognitive impairment (MCI) in Parkinson disease (PD).
Results SPM revealed decreased prefrontal and parietal metabolism (p Conclusions Early cognitive decline in Parkinson disease as defined by mild cognitive impairment is associated with discrete regional changes and abnormal metabolic network activity.

Why it matters

This study found decreased prefrontal and parietal metabolism and abnormal metabolic network activity in people with Parkinson's disease who also had mild cognitive impairment. It concerns cognitive decline in Parkinson's disease rather than Alzheimer's disease, and it does not test any treatment.

Study details

Participants18
Evidence strengthModerate

How this study scored 56/100

Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Neurology)
Journal's citation record	4 / 4	Neurology: journal h-index 525 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2008 — within 20 year(s) of the newest study here
Sample size	1 / 4	18 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 234 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	11.7 citations a year over 20 year(s) since 2008
Impact for its field and year	4 / 6	Cited 14.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 6 other studies in this library
Still being cited	2 / 4	Cited 15 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author David Eidelberg: h-index 99 (OpenAlex, whole career)
Institution's track record	2 / 3	New York University: institution h-index 1,612 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 18367705)
Free to read	0 / 2	Behind a paywall — scores zero
Total	56 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

APA 7th

Huang, C., Mattis, P., Perrine, K., Brown, N., Dhawan, V., & Eidelberg, D. (2008). Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease. Neurology. https://doi.org/10.1212/01.wnl.0000304050.05332.9c

Vancouver

Huang C, Mattis P, Perrine K, Brown N, Dhawan V, Eidelberg D. Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease. Neurology. 2008. doi:10.1212/01.wnl.0000304050.05332.9c. PMID: 18367705.

BibTeX

@article{huang2008-18367705,
  author  = {Huang, C. and Mattis, P. and Perrine, K. and Brown, N. and Dhawan, V. and Eidelberg, D.},
  title   = {{Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease}},
  journal = {Neurology},
  year    = {2008},
  doi     = {10.1212/01.wnl.0000304050.05332.9c},
  pmid    = {18367705},
  url     = {https://doi.org/10.1212/01.wnl.0000304050.05332.9c}
}

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