Home › Research › TREM2 and immune genetics
Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease
Thrash JC, Torbett BE, Carson MJ.. Neurochemical research, 2008-04-11
Topic: Brain proteins, microglia and lab models
Trem2 is an orphan, DAP12 associated receptor constitutively expressed in vivo by subsets of microglia in the healthy adult murine CNS and in vitro by subsets of oligodendrocytes in neonatal mixed glial cultures. Loss of a functional Trem2 signaling pathway is the genetic cause of Nasu-Hakola disease. Whether the early onset cognitive dementia and myelin-pallor associated with this disorder are due to deficits in functional Trem2 signaling in microglia and/or oligodendrocytes is still being debated.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Thrash, J. C., Torbett, B. E., & Carson, M. J. (2009). Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease. Neurochemical research. https://doi.org/10.1007/s11064-008-9657-1
Vancouver
Thrash JC, Torbett BE, Carson MJ. Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease. Neurochemical research. 2009. doi:10.1007/s11064-008-9657-1. PMID: 18404378.
BibTeX
@article{thrash2009-18404378,
author = {Thrash, J. C. and Torbett, B. E. and Carson, M. J.},
title = {{Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease}},
journal = {Neurochemical research},
year = {2009},
doi = {10.1007/s11064-008-9657-1},
pmid = {18404378},
url = {https://doi.org/10.1007/s11064-008-9657-1}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Loss of a functional Trem2 signaling pathway is the genetic cause of Nasu-Hakola disease.
- Whether the early onset cognitive dementia and myelin-pallor associated with this disorder are due to deficits in functional Trem2 signaling in microglia and/or oligodendrocytes is still being debated.
- Here, we find that Trem2/DAP12 expression is detected in embryonic day 14 CNS mRNA.
- Using dual immunohistochemistry/in situ hybridization, we find that both Trem2 and DAP12 expression always co-localized with markers of microglia/macrophages.
Why it matters
This study describes when and where TREM2 and DAP12 are expressed in the developing mouse brain and discusses Nasu-Hakola disease. It is early animal work and does not show that any treatment prevents or cures Alzheimer's disease.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurochemical research) |
| Journal's citation record | 2 / 4 | Neurochemical Research: journal h-index 163 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “murine”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 103 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.4 citations a year over 19 year(s) since 2009 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 23 other studies in this library |
| Still being cited | 1 / 4 | Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Monica J. Carson: h-index 42 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Scripps Research Institute: institution h-index 1,076 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 18404378) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 40 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Related
Studies in the library that share something with this one. The line above each title says what.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
23 studies in the alzhub library list this one in their references. Showing the 8 highest-scoring.
Related studies in TREM2 and immune genetics
Also tagged “r47h”
363 studies in the library carry the topic tag “r47h”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 363 tagged studies.