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Amyloid precursor protein trafficking, processing, and function
Thinakaran G, Koo EH.. The Journal of biological chemistry, 2008-07-23
Topic: Amyloid, tau and blood-test diagnosis
Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations over the past two decades. APP is the precursor to the amyloid beta-protein (Abeta), the 38-43-amino acid residue peptide that is at the heart of the amyloid cascade hypothesis of Alzheimer disease (AD). Tremendous progress has been made since the initial identification of Abeta as the principal component of brain senile plaques of individuals with AD.
Key findings
- APP is the precursor to the amyloid beta-protein (Abeta), the 38-43-amino acid residue peptide that is at the heart of the amyloid cascade hypothesis of Alzheimer disease (AD).
- Tremendous progress has been made since the initial identification of Abeta as the principal component of brain senile plaques of individuals with AD.
- Specifically, molecular characterization of the secretases involved in Abeta production has facilitated cell biological investigations on APP processing and advanced efforts to model AD pathogenesis in animal models.
- This minireview summarizes salient features of APP trafficking and amyloidogenic processing and discusses the putative biological functions of APP.
Why it matters
This review describes how amyloid precursor protein is trafficked and processed to produce amyloid-beta, the peptide central to the amyloid cascade hypothesis of Alzheimer's disease. It summarizes scientific understanding but does not report a new treatment or prevention.
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Study details
- Evidence strengthLow
How this study scored 55/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The Journal of biological chemistry) |
| Journal's citation record | 4 / 4 | Journal of Biological Chemistry: journal h-index 780 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2008 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,146 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 57.3 citations a year over 20 year(s) since 2008 |
| Impact for its field and year | 6 / 6 | Cited 40.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 20 other studies in this library |
| Still being cited | 3 / 4 | Cited 131 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Edward H. Koo: h-index 88 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California San Diego: institution h-index 1,852 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 18650430) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1074/jbc.r800019200
- PubMed: 18650430
- Original source →
- Free full text: Journal of Biological Chemistry →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Thinakaran, G., & Koo, E. H. (2008). Amyloid precursor protein trafficking, processing, and function. The Journal of biological chemistry. https://doi.org/10.1074/jbc.r800019200
Vancouver
Thinakaran G, Koo EH. Amyloid precursor protein trafficking, processing, and function. The Journal of biological chemistry. 2008. doi:10.1074/jbc.r800019200. PMID: 18650430.
BibTeX
@article{thinakaran2008-18650430,
author = {Thinakaran, G. and Koo, E. H.},
title = {{Amyloid precursor protein trafficking, processing, and function}},
journal = {The Journal of biological chemistry},
year = {2008},
doi = {10.1074/jbc.r800019200},
pmid = {18650430},
url = {https://doi.org/10.1074/jbc.r800019200}
}
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