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69/100

✓ Peer-reviewed alzhub usefulness score 69 out of 100. Treatments

Topic: Risk, prevention and care in population studies

Objective To determine whether cardiovascular (CV) risk is associated with subtle memory deficits in non-demented, healthy older women with a family history of Alzheimer disease (AD). Methods Baseline data of 375 participants from a randomized, double-blind placebo-controlled primary prevention trial to test the efficacy of hormone replacement therapy in delaying AD and cognitive decline were analyzed. All subjects were women over 65 with a family history of AD who had normal cognition and no active heart disease at baseline. A baseline memory composite score was calculated, consisting of immediate and delayed recall of verbal and nonverbal material. Multiple linear regression was performed to examine the association of relative CV risk with memory functioning; age, ethnicity and education level were included as covariates. Results Mean baseline memory composite score was significantly higher in those with low relative CHD risk than those with high relative CHD risk. Conclusion These findings suggest that subtle elevation of CHD risk may negatively affect memory functioning even in otherwise healthy, non-demented older women without a history of heart disease.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Wang, S., Jacobs, D., Andrews, H., Tsai, W. Y., Luo, X., Bergmann, C., et al. (2010). Cardiovascular risk and memory in non-demented elderly women. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2008.08.007

Vancouver

Wang S, Jacobs D, Andrews H, Tsai WY, Luo X, Bergmann C, et al. Cardiovascular risk and memory in non-demented elderly women. Neurobiology of aging. 2010. doi:10.1016/j.neurobiolaging.2008.08.007. PMID: 18805604.

BibTeX

@article{wang2010-18805604,
  author  = {Wang, S. and Jacobs, D. and Andrews, H. and Tsai, W. Y. and Luo, X. and Bergmann, C. and Sano, M.},
  title   = {{Cardiovascular risk and memory in non-demented elderly women}},
  journal = {Neurobiology of aging},
  year    = {2010},
  doi     = {10.1016/j.neurobiolaging.2008.08.007},
  pmid    = {18805604},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2008.08.007}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

Objective To determine whether cardiovascular (CV) risk is associated with subtle memory deficits in non-demented, healthy older women with a family history of Alzheimer disease (AD).
Results Mean baseline memory composite score was significantly higher in those with low relative CHD risk than those with high relative CHD risk.
Conclusion These findings suggest that subtle elevation of CHD risk may negatively affect memory functioning even in otherwise healthy, non-demented older women without a history of heart disease.

Why it matters

In 375 non-demented older women with a family history of Alzheimer's disease, those with higher coronary heart disease risk had lower baseline memory scores. This is an observational association and does not show that reducing heart risk prevents Alzheimer's disease.

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Study details

Participants375
Evidence strengthHigh

How this study scored 69/100

Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, still being cited, senior author's track record and institution's track record, so those were left out: it earned 46 of the 67 points we could judge it on, which is 69 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Neurobiology of aging)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	11 / 12	A randomised controlled trial (from PubMed type “Randomized Controlled Trial”)
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2010 — within 20 year(s) of the newest study here
Sample size	2 / 4	375 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	2 / 2	Randomised and blinded or placebo-controlled (as stated in the record)
Times cited	— / 7	No citation count (OpenAlex dates this DOI to 2008, the record says 2010; OpenAlex values not used) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multi-centre collaboration	2 / 3	PubMed indexes it as a multicentre study
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 18805604)
Free to read	0 / 2	Behind a paywall — scores zero
Points	46 / 67	Scored on 13 of 20 parts. We have no data for the rest, so they are left out: 46 of the 67 points we could judge it on is 69 out of 100.
Total	69 / 100	—

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