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53/100

✓ Peer-reviewed alzhub usefulness score 53 out of 100. Brain scans and imaging

Topic: Brain proteins, microglia and lab models

Background Although a majority of patients with amnestic mild cognitive impairment (aMCI) progress to Alzheimer disease, the natural history of nonamnestic MCI (naMCI) is less clear. Noninvasive imaging surrogates for underlying pathological findings in MCI would be clinically useful for identifying patients who may benefit from disease-specific treatments at the prodromal stage of dementia. Objective To determine the characteristic magnetic resonance imaging (MRI) and proton MR spectroscopy (1H MRS) profiles of MCI subtypes. Design Case-control study. Setting Community-based sample at a tertiary referral center. Patients Ninety-one patients with single-domain aMCI, 32 patients with multiple-domain aMCI, 20 patients with single- or multiple-domain naMCI, and 100 cognitively normal elderly subjects frequency-matched by age and sex. Main outcome measures Posterior cingulate gyrus 1H MRS metabolite ratios, hippocampal volumes, and cerebrovascular disease on MRI. Results Patients with single-domain aMCI were characterized by small hippocampal volumes and elevated ratios of myo-inositol to creatine levels. Patients with naMCI on average had normal hippocampal volumes and 1H MRS metabolite ratios, but a greater proportion (3 of 20 patients [15%]) had cortical infarctions compared with patients with single-domain aMCI (6 of 91 [7%]). For characterization of MCI subtypes, 1H MRS and structural MRI findings were complementary. Conclusions The MRI and 1H MRS findings in single-domain aMCI are consistent with a pattern similar to that of Alzheimer disease. Absence of this pattern on average in patients with naMCI suggests that cerebrovascular disease and other neurodegenerative diseases may be contributing to the cognitive impairment in many individuals with naMCI.

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APA 7th

Kantarci, K., Petersen, R. C., Przybelski, S. A., Weigand, S. D., Shiung, M. M., Whitwell, J. L., et al. (2008). Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypes. Archives of neurology. https://doi.org/10.1001/archneur.65.12.1621

Vancouver

Kantarci K, Petersen RC, Przybelski SA, Weigand SD, Shiung MM, Whitwell JL, et al. Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypes. Archives of neurology. 2008. doi:10.1001/archneur.65.12.1621. PMID: 19064749.

BibTeX

@article{kantarci2008-19064749,
  author  = {Kantarci, K. and Petersen, R. C. and Przybelski, S. A. and Weigand, S. D. and Shiung, M. M. and Whitwell, J. L. and Negash, S. and Ivnik, R. J. and others},
  title   = {{Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypes}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneur.65.12.1621},
  pmid    = {19064749},
  url     = {https://doi.org/10.1001/archneur.65.12.1621}
}

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Key findings

Results Patients with single-domain aMCI were characterized by small hippocampal volumes and elevated ratios of myo-inositol to creatine levels.
Patients with naMCI on average had normal hippocampal volumes and 1H MRS metabolite ratios, but a greater proportion (3 of 20 patients [15%]) had cortical infarctions compared with patients with single-domain aMCI (6 of 91 [7%]).
Absence of this pattern on average in patients with naMCI suggests that cerebrovascular disease and other neurodegenerative diseases may be contributing to the cognitive impairment in many individuals with naMCI.

Why it matters

This case-control study found that people with single-domain amnestic mild cognitive impairment tended to have small hippocampal volumes and elevated myo-inositol to creatine ratios. It describes imaging and spectroscopy patterns that may help distinguish mild cognitive impairment subtypes, but it does not test a treatment, cure, or prevention.

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Study details

Study designcase-control study
Participants32
Evidence strengthModerate

How this study scored 53/100

Published in a peer-reviewed journal, and it is a case-control study. Scored zero for effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Archives of neurology)
Journal's citation record	3 / 4	Archives of Neurology: journal h-index 353 (OpenAlex, 2026-10-29)
Study design	6 / 12	A case-control study
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2008 — within 20 year(s) of the newest study here
Sample size	1 / 4	32 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 86 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	4.3 citations a year over 20 year(s) since 2008
Impact for its field and year	2 / 6	Cited 1.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 4 other studies in this library
Still being cited	1 / 4	Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Clifford R. Jack: h-index 203 (OpenAlex, whole career)
Institution's track record	2 / 3	Mayo Clinic: institution h-index 1,606 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 19064749)
Free to read	0 / 2	Behind a paywall — scores zero
Total	53 / 100	—

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