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Vascular risk factors and dementia: how to move forward?
Viswanathan A, Rocca WA, Tzourio C.. Neurology, 2009-01-01
Topic: Risk, prevention and care in population studies
In recent years, accumulating evidence has suggested that vascular risk factors contribute to Alzheimer disease (AD). Vascular dementia had been traditionally considered secondary to stroke and vascular disease. It has been traditionally distinguished from AD, considered to be a purely neurodegenerative form of dementia. However, in light of this more recent literature, it appears that there is a spectrum: ranging from patients with pure vascular dementia to patients with pure AD and including a large majority of patients with contributions from both Alzheimer and vascular pathologies. In this article, we discuss the impact of vascular risk factors on AD and its consequences at the individual level and at the population level by highlighting the concept of attributable risk. We then discuss the key questions and next steps involved in designing a therapeutic trial to control vascular risk factors for the prevention of dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Viswanathan, A., Rocca, W. A., & Tzourio, C. (2009). Vascular risk factors and dementia: how to move forward? Neurology. https://doi.org/10.1212/01.wnl.0000341271.90478.8e
Vancouver
Viswanathan A, Rocca WA, Tzourio C. Vascular risk factors and dementia: how to move forward? Neurology. 2009. doi:10.1212/01.wnl.0000341271.90478.8e. PMID: 19171835.
BibTeX
@article{viswanathan2009-19171835,
author = {Viswanathan, A. and Rocca, W. A. and Tzourio, C.},
title = {{Vascular risk factors and dementia: how to move forward?}},
journal = {Neurology},
year = {2009},
doi = {10.1212/01.wnl.0000341271.90478.8e},
pmid = {19171835},
url = {https://doi.org/10.1212/01.wnl.0000341271.90478.8e}
}
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Key findings
- In recent years, accumulating evidence has suggested that vascular risk factors contribute to Alzheimer disease (AD).
Why it matters
This article discusses accumulating evidence that vascular risk factors contribute to Alzheimer disease, describing a spectrum from pure vascular dementia to pure Alzheimer's disease with most patients having contributions from both. It discusses designing a therapeutic trial to control vascular risk factors for dementia prevention.
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Study details
- Evidence strengthLow
How this study scored 57/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 415 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 21.8 citations a year over 19 year(s) since 2009 |
| Impact for its field and year | 5 / 6 | Cited 24.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 41 other studies in this library |
| Still being cited | 2 / 4 | Cited 36 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Christophe Tzourio: h-index 126 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 19171835) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 57 / 100 | — |
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Read the original
- DOI: 10.1212/01.wnl.0000341271.90478.8e
- PubMed: 19171835
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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