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Longitudinal pattern of regional brain volume change differentiates normal aging from MCI
Driscoll I, Davatzikos C, An Y, Wu X, Shen D, Kraut M, Resnick SM.. Neurology, 2009-06-01
Topic: Risk, prevention and care in population studies
Background Neuroimaging measures have potential as surrogate markers of disease through identification of consistent features that occur prior to clinical symptoms. Despite numerous investigations, especially in relation to the transition to clinical impairment, the regional pattern of brain changes in clinically normal older adults has not been established. We predict that the regions that show early pathologic changes in association with Alzheimer disease will show accelerated volume loss in mild cognitive impairment (MCI) compared to normal aging. Methods Through the Baltimore Longitudinal Study of Aging, we prospectively evaluated 138 nondemented individuals (age 64-86 years) annually for up to 10 consecutive years. Eighteen participants were diagnosed with MCI over the course of the study. Mixed-effects regression was used to compare regional brain volume trajectories of clinically normal individuals to those with MCI based on a total of 1,017 observations. Results All investigated volumes declined with normal aging (p Conclusion Although age-related regional volume loss is apparent and widespread in nondemented individuals, mild cognitive impairment is associated with a unique pattern of structural vulnerability reflected in differential volume loss in specific regions. Early identification of patterns of abnormality is of fundamental importance for detecting disease onset and tracking progression.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Driscoll, I., Davatzikos, C., An, Y., Wu, X., Shen, D., Kraut, M., et al. (2009). Longitudinal pattern of regional brain volume change differentiates normal aging from MCI. Neurology. https://doi.org/10.1212/wnl.0b013e3181a82634
Vancouver
Driscoll I, Davatzikos C, An Y, Wu X, Shen D, Kraut M, et al. Longitudinal pattern of regional brain volume change differentiates normal aging from MCI. Neurology. 2009. doi:10.1212/wnl.0b013e3181a82634. PMID: 19487648.
BibTeX
@article{driscoll2009-19487648,
author = {Driscoll, I. and Davatzikos, C. and An, Y. and Wu, X. and Shen, D. and Kraut, M. and Resnick, S. M.},
title = {{Longitudinal pattern of regional brain volume change differentiates normal aging from MCI}},
journal = {Neurology},
year = {2009},
doi = {10.1212/wnl.0b013e3181a82634},
pmid = {19487648},
url = {https://doi.org/10.1212/wnl.0b013e3181a82634}
}
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Key findings
- We predict that the regions that show early pathologic changes in association with Alzheimer disease will show accelerated volume loss in mild cognitive impairment (MCI) compared to normal aging.
- Results All investigated volumes declined with normal aging (p < 0.05).
Why it matters
In this longitudinal study, all brain volumes declined with normal aging, but mild cognitive impairment was associated with a distinct pattern of greater volume loss in specific regions. This suggests imaging can help distinguish MCI from normal aging, but it is an observational finding with no treatment tested.
Study details
- Study designlongitudinal study
- Participants1,017
- Evidence strengthModerate
How this study scored 70/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,017 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 536 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 28.2 citations a year over 19 year(s) since 2009 |
| Impact for its field and year | 4 / 6 | Cited 17.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 20 other studies in this library |
| Still being cited | 3 / 4 | Cited 73 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Susan M. Resnick: h-index 117 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Johns Hopkins University: institution h-index 2,306 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 19487648) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 70 / 100 | — |
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