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Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury
Marklund N, Blennow K, Zetterberg H, Ronne-Engström E, Enblad P, Hillered L.. Journal of neurosurgery, 2009-06-01
Topic: Brain proteins, microglia and lab models
Object Damage to axons contributes to postinjury disabilities and is commonly observed following traumatic brain injury (TBI). Traumatic brain injury is an important environmental risk factor for the development of Alzheimer disease (AD). In the present feasibility study, the aim was to use intracerebral microdialysis catheters with a high molecular cutoff membrane (100 kD) to harvest interstitial total tau (T-tau) and amyloid beta 1-42 (Abeta42) proteins, which are important biomarkers for axonal injury and for AD, following moderate-to-severe TBI.
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APA 7th
Marklund, N., Blennow, K., Zetterberg, H., Ronne-Engström, E., Enblad, P., & Hillered, L. (2009). Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury. Journal of neurosurgery. https://doi.org/10.3171/2008.9.jns08584
Vancouver
Marklund N, Blennow K, Zetterberg H, Ronne-Engström E, Enblad P, Hillered L. Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury. Journal of neurosurgery. 2009. doi:10.3171/2008.9.jns08584. PMID: 19216653.
BibTeX
@article{marklund2009-19216653,
author = {Marklund, N. and Blennow, K. and Zetterberg, H. and Ronne-Engström, E. and Enblad, P. and Hillered, L.},
title = {{Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury}},
journal = {Journal of neurosurgery},
year = {2009},
doi = {10.3171/2008.9.jns08584},
pmid = {19216653},
url = {https://doi.org/10.3171/2008.9.jns08584}
}
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Key findings
- Traumatic brain injury is an important environmental risk factor for the development of Alzheimer disease (AD).
- In the present feasibility study, the aim was to use intracerebral microdialysis catheters with a high molecular cutoff membrane (100 kD) to harvest interstitial total tau (T-tau) and amyloid beta 1-42 (Abeta42) proteins, which are important biomarkers for axonal injury and for AD, following moderate-to-severe TBI.
- Methods Eight patients (5 men and 3 women) were included in the study; 5 of the patients had a focal/mixed TBI and 3 had a diffuse axonal injury (DAI).
- Following the bedside analysis of the routinely measured energy metabolic markers (that is, glucose, lactate/pyruvate ratio, glycerol, and glutamate), the remaining dialysate was pooled and two 12-hour samples per day were used to analyze T-tau and Abeta42 by enzyme-linked immunosorbent assay from Day 1 up to 8 days postinjury.
Why it matters
This feasibility study used intracerebral microdialysis to collect interstitial total tau and amyloid beta 1-42 proteins in eight patients after moderate-to-severe traumatic brain injury. It is a small early feasibility study and does not test any treatment, cure, or prevention for Alzheimer disease.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neurosurgery) |
| Journal's citation record | 3 / 4 | Journal of neurosurgery: journal h-index 357 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 137 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.2 citations a year over 19 year(s) since 2009 |
| Impact for its field and year | 3 / 6 | Cited 6.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Lars Hillered: h-index 62 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Sahlgrenska University Hospital: institution h-index 715 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 19216653) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
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