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Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia
Reisa Anne Sperling, Peter S. LaViolette, Kelly O’Keefe, Jacqueline L. O’Brien, Dorene M. Rentz, Maija M. Pihlajamaki, Gad A. Marshall, Bradley T. Hyman, Dennis J. Selkoe, Trey Hedden, Randy Lee Buckner, John Alex Becker, Keith A. Johnson. Neuron, 2009-07-01
Topic: Amyloid, tau and blood-test diagnosis
We do not hold a plain-English summary of this study yet. Use the links to the original below for its abstract and findings.
Why it matters
Reports that amyloid deposition was associated with impaired default network function in older people without dementia.
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How this study scored 59/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 56 of the 95 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuron) |
| Journal's citation record | 4 / 4 | Neuron: journal h-index 689 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,033 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 54.4 citations a year over 19 year(s) since 2009 |
| Impact for its field and year | 6 / 6 | Cited 42.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 129 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Keith A. Johnson: h-index 127 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 19640477) |
| Free to read | 2 / 2 | Free to read |
| Points | 56 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 56 of the 95 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 13 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Sperling, R. A., LaViolette, P. S., O’Keefe, K., O’Brien, J. L., Rentz, D. M., Pihlajamaki, M. M., et al. (2009). Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia. Neuron. https://doi.org/10.1016/j.neuron.2009.07.003
Vancouver
Sperling RA, LaViolette PS, O’Keefe K, O’Brien JL, Rentz DM, Pihlajamaki MM, et al. Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia. Neuron. 2009. doi:10.1016/j.neuron.2009.07.003. PMID: 19640477.
BibTeX
@article{sperling2009-19640477,
author = {Sperling, Reisa Anne and LaViolette, Peter S. and O’Keefe, Kelly and O’Brien, Jacqueline L. and Rentz, Dorene M. and Pihlajamaki, Maija M. and Marshall, Gad A. and Hyman, Bradley T. and Selkoe, Dennis J. and Hedden, Trey and Buckner, Randy Lee and Becker, John Alex and Johnson, Keith A.},
title = {{Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia}},
journal = {Neuron},
year = {2009},
doi = {10.1016/j.neuron.2009.07.003},
pmid = {19640477},
url = {https://doi.org/10.1016/j.neuron.2009.07.003}
}