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Neighborhood environmental deprivation predicts the generalized neurocognitive deficit in schizophrenia
Luyu Zhang, Zhixin Zhang, Gregory P. Strauss. Schizophrenia Research, 2025-12-19
Topic: Brain proteins, microglia and lab models
= 0.14. The effect of ADI score was also significant, β = -0.36, t = -2.30, p < .05; while the effect of RUCC, β = 0.06, t = 0.34, p = .73, and the interaction between ADI and RUCC, β = -0.001, t = 0.27, p = .99, were nonsignificant. Neighborhood-level environmental deprivation predicted cognitive impairment in SZ. This highlights the need to incorporate environment-focused interventions when treating cognitive impairment in SZ.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zhang, L., Zhang, Z., & Strauss, G. P. (2025). Neighborhood environmental deprivation predicts the generalized neurocognitive deficit in schizophrenia. Schizophrenia Research. https://doi.org/10.1016/j.schres.2025.12.006
Vancouver
Zhang L, Zhang Z, Strauss GP. Neighborhood environmental deprivation predicts the generalized neurocognitive deficit in schizophrenia. Schizophrenia Research. 2025. doi:10.1016/j.schres.2025.12.006. PMID: 41421073.
BibTeX
@article{zhang2025-41421073,
author = {Zhang, Luyu and Zhang, Zhixin and Strauss, Gregory P.},
title = {{Neighborhood environmental deprivation predicts the generalized neurocognitive deficit in schizophrenia}},
journal = {Schizophrenia Research},
year = {2025},
doi = {10.1016/j.schres.2025.12.006},
pmid = {41421073},
url = {https://doi.org/10.1016/j.schres.2025.12.006}
}
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Key findings
- The effect of ADI score was also significant, β = -0.36, t = -2.30, p < .05; while the effect of RUCC, β = 0.06, t = 0.34, p = .73, and the interaction between ADI and RUCC, β = -0.001, t = 0.27, p = .99, were nonsignificant.
- Neighborhood-level environmental deprivation predicted cognitive impairment in SZ.
- This highlights the need to incorporate environment-focused interventions when treating cognitive impairment in SZ.
Why it matters
In people with schizophrenia, living in a more environmentally deprived neighborhood predicted worse cognitive impairment. The authors suggest this means environment-focused approaches should be considered when treating cognitive impairment in schizophrenia, though the study was cross-sectional and cannot show cause and effect.
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Study details
- Study designcross-sectional
- Participants114
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Schizophrenia Research) |
| Journal's citation record | 2 / 4 | Schizophrenia Research: journal h-index 240 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 114 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Gregory P. Strauss: h-index 58 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Georgia: institution h-index 904 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41421073) |
| Free to read | 2 / 2 | Free to read |
| Total | 41 / 100 | — |
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Read the original
- DOI: 10.1016/j.schres.2025.12.006
- PubMed: 41421073
- Original source →
- Free full text: Schizophrenia Research →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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