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45/100

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Risk genes beyond APOE

Topic: Brain proteins, microglia and lab models

Ectopic cell cycle events (CCEs) mark vulnerable neuronal populations in human Alzheimer disease (AD) and are observed early in disease progression. In transgenic mouse models of AD, CCEs are found before the onset of beta-amyloid peptide (Abeta) deposition to form senile plaques, a hallmark of AD. Here, we have demonstrated that alterations in brain microglia occur coincidently with the appearance of CCEs in the R1.40 transgenic mouse model of AD.

Key findings

In transgenic mouse models of AD, CCEs are found before the onset of beta-amyloid peptide (Abeta) deposition to form senile plaques, a hallmark of AD.
Here, we have demonstrated that alterations in brain microglia occur coincidently with the appearance of CCEs in the R1.40 transgenic mouse model of AD.
Furthermore, promotion of inflammation with LPS at young ages in R1.40 mice induced the early appearance of neuronal CCEs, whereas treatment with 2 different nonsteroidal antiinflammatory drugs (NSAIDs) blocked neuronal CCEs and alterations in brain microglia without altering amyloid precursor protein (APP) processing and steady-state Abeta levels.
In addition, NSAID treatment of older R1.40 animals prevented new neuronal CCEs, although it failed to reverse existing ones.

Why it matters

In the R1.40 transgenic mouse model of Alzheimer's disease, two different nonsteroidal anti-inflammatory drugs prevented but did not reverse neuronal cell cycle reentry. This is mouse work, and it found prevention but not reversal, so it does not show a treatment that helps people with existing disease.

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Study details

Evidence strengthLow

How this study scored 45/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The Journal of clinical investigation)
Journal's citation record	4 / 4	Journal of Clinical Investigation: journal h-index 706 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2009 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Laboratory or animal study (title names “mouse”) — scores zero
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 121 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	6.4 citations a year over 19 year(s) since 2009
Impact for its field and year	4 / 6	Cited 9.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 5 other studies in this library
Still being cited	1 / 4	Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Karl Herrup: h-index 76 (OpenAlex, whole career)
Institution's track record	1 / 3	Case Western Reserve University: institution h-index 1,159 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 19907078)
Free to read	0 / 2	Behind a paywall — scores zero
Total	45 / 100	—

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Read the original

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

APA 7th

Varvel, N. H., Bhaskar, K., Kounnas, M. Z., Wagner, S. L., Yang, Y., Lamb, B. T., et al. (2009). NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. The Journal of clinical investigation. https://doi.org/10.1172/jci39716

Vancouver

Varvel NH, Bhaskar K, Kounnas MZ, Wagner SL, Yang Y, Lamb BT, et al. NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. The Journal of clinical investigation. 2009. doi:10.1172/jci39716. PMID: 19907078.

BibTeX

@article{varvel2009-19907078,
  author  = {Varvel, N. H. and Bhaskar, K. and Kounnas, M. Z. and Wagner, S. L. and Yang, Y. and Lamb, B. T. and Herrup, K.},
  title   = {{NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease}},
  journal = {The Journal of clinical investigation},
  year    = {2009},
  doi     = {10.1172/jci39716},
  pmid    = {19907078},
  url     = {https://doi.org/10.1172/jci39716}
}

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