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47/100

✓ Peer-reviewed alzhub usefulness score 47 out of 100. Inflammation and the immune system

Topic: Brain proteins, microglia and lab models

To date there is no effective therapy for Alzheimer disease (AD). High levels of circulating high density lipoprotein (HDL) and its main protein, apolipoprotein A-I (apoA-I), reduce the risk of cardiovascular disease. Clinical studies show that plasma HDL cholesterol and apoA-I levels are low in patients with AD.

Key findings

High levels of circulating high density lipoprotein (HDL) and its main protein, apolipoprotein A-I (apoA-I), reduce the risk of cardiovascular disease.
Clinical studies show that plasma HDL cholesterol and apoA-I levels are low in patients with AD.
To investigate if increasing plasma apoA-I/HDL levels ameliorates AD-like memory deficits and amyloid-β (Aβ) deposition, we generated a line of triple transgenic (Tg) mice overexpressing mutant forms of amyloid-β precursor protein (APP) and presenilin 1 (PS1) as well as human apoA-I (AI).
Here we show that APP/PS1/AI triple Tg mice have a 2-fold increase of plasma HDL cholesterol levels.

Why it matters

In a mouse model of Alzheimer's disease, overexpressing human apolipoprotein A-I preserved cognitive function and attenuated neuroinflammation and cerebral amyloid angiopathy. This is animal work, so it does not show that raising apoA-I or HDL treats or prevents Alzheimer's disease in people.

Study details

Evidence strengthLow

How this study scored 47/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The Journal of biological chemistry)
Journal's citation record	4 / 4	Journal of Biological Chemistry: journal h-index 780 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2010 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Laboratory or animal study (title names “mouse”) — scores zero
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 208 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	11.6 citations a year over 18 year(s) since 2010
Impact for its field and year	3 / 6	Cited 5.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 5 other studies in this library
Still being cited	2 / 4	Cited 33 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Ling Li: h-index 72 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Minnesota: institution h-index 1,568 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 20847045)
Free to read	0 / 2	Behind a paywall — scores zero
Total	47 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Lewis, T. L., Cao, D., Lu, H., Mans, R. A., Su, Y. R., Jungbauer, L., et al. (2010). Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease. The Journal of biological chemistry. https://doi.org/10.1074/jbc.m110.127829

Vancouver

Lewis TL, Cao D, Lu H, Mans RA, Su YR, Jungbauer L, et al. Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease. The Journal of biological chemistry. 2010. doi:10.1074/jbc.m110.127829. PMID: 20847045.

BibTeX

@article{lewis2010-20847045,
  author  = {Lewis, T. L. and Cao, D. and Lu, H. and Mans, R. A. and Su, Y. R. and Jungbauer, L. and Linton, M. F. and Fazio, S. and others},
  title   = {{Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.127829},
  pmid    = {20847045},
  url     = {https://doi.org/10.1074/jbc.m110.127829}
}

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