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Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans
Zetterberg H, Mörtberg E, Song L, Chang L, Provuncher GK, Patel PP, Ferrell E, Fournier DR et al.. PloS one, 2011-12-14
Topic: Brain proteins, microglia and lab models
Amyloid β (Aβ) peptides are proteolytic products from amyloid precursor protein (APP) and are thought to play a role in Alzheimer disease (AD) pathogenesis. While much is known about molecular mechanisms underlying cerebral Aβ accumulation in familial AD, less is known about the cause(s) of brain amyloidosis in sporadic disease. Animal and postmortem studies suggest that Aβ secretion can be up-regulated in response to hypoxia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zetterberg, H., Mörtberg, E., Song, L., Chang, L., Provuncher, G. K., Patel, P. P., et al. (2011). Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans. PloS one. https://doi.org/10.1371/journal.pone.0028263
Vancouver
Zetterberg H, Mörtberg E, Song L, Chang L, Provuncher GK, Patel PP, et al. Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans. PloS one. 2011. doi:10.1371/journal.pone.0028263. PMID: 22194817.
BibTeX
@article{zetterberg2011-22194817,
author = {Zetterberg, H. and Mörtberg, E. and Song, L. and Chang, L. and Provuncher, G. K. and Patel, P. P. and Ferrell, E. and Fournier, D. R. and others},
title = {{Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans}},
journal = {PloS one},
year = {2011},
doi = {10.1371/journal.pone.0028263},
pmid = {22194817},
url = {https://doi.org/10.1371/journal.pone.0028263}
}
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Key findings
- While much is known about molecular mechanisms underlying cerebral Aβ accumulation in familial AD, less is known about the cause(s) of brain amyloidosis in sporadic disease.
- Animal and postmortem studies suggest that Aβ secretion can be up-regulated in response to hypoxia.
- We employed a new technology (Single Molecule Arrays, SiMoA) capable of ultrasensitive protein measurements and developed a novel assay to look for changes in serum Aβ42 concentration in 25 resuscitated patients with severe hypoxia due to cardiac arrest.
- After a lag period of 10 or more hours, very clear serum Aβ42 elevations were observed in all patients.
Why it matters
In 25 patients resuscitated after cardiac arrest, serum amyloid beta 42 levels rose over time after hypoxia, using an ultrasensitive assay. This is a small human study of a possible trigger for amyloid buildup and reports no treatment, cure or prevention.
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Study details
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (PloS one) |
| Journal's citation record | 4 / 4 | PLoS ONE: journal h-index 594 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 173 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.2 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 3 / 6 | Cited 7.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 7 other studies in this library |
| Still being cited | 2 / 4 | Cited 17 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Kaj Blennow: h-index 220 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Uppsala University: institution h-index 1,114 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 22194817) |
| Free to read | 2 / 2 | Free to read |
| Total | 48 / 100 | — |
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