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Cognitive disorders and dementia in CKD: the neglected kidney-brain axis
Bugnicourt JM, Godefroy O, Chillon JM, Choukroun G, Massy ZA.. Journal of the American Society of Nephrology : JASN, 2013-01-04
Topic: Risk, prevention and care in population studies
Epidemiologic data suggest that individuals at all stages of CKD have a higher risk of developing cognitive disorders and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including direct neuronal injury by uremic toxins, could also be involved, especially in the absence of obvious cerebrovascular disease. We discuss the prevalence and characteristics of cognitive disorders and dementia in patients with CKD, brain imaging findings, and traditional and nontraditional risk factors. Understanding the pathophysiologic interactions between renal impairment and brain function is important in order to minimize the risk for future cognitive impairment.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Bugnicourt, J. M., Godefroy, O., Chillon, J. M., Choukroun, G., & Massy, Z. A. (2013). Cognitive disorders and dementia in CKD: the neglected kidney-brain axis. Journal of the American Society of Nephrology : JASN. https://doi.org/10.1681/asn.2012050536
Vancouver
Bugnicourt JM, Godefroy O, Chillon JM, Choukroun G, Massy ZA. Cognitive disorders and dementia in CKD: the neglected kidney-brain axis. Journal of the American Society of Nephrology : JASN. 2013. doi:10.1681/asn.2012050536. PMID: 23291474.
BibTeX
@article{bugnicourt2013-23291474,
author = {Bugnicourt, J. M. and Godefroy, O. and Chillon, J. M. and Choukroun, G. and Massy, Z. A.},
title = {{Cognitive disorders and dementia in CKD: the neglected kidney-brain axis}},
journal = {Journal of the American Society of Nephrology : JASN},
year = {2013},
doi = {10.1681/asn.2012050536},
pmid = {23291474},
url = {https://doi.org/10.1681/asn.2012050536}
}
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Key findings
- Epidemiologic data suggest that individuals at all stages of CKD have a higher risk of developing cognitive disorders and dementia.
Why it matters
This review reports that people at all stages of chronic kidney disease have a higher risk of developing cognitive disorders and dementia, possibly through cerebrovascular lesions or direct neuronal injury by uremic toxins. It discusses possible mechanisms but does not test any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 52/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the American Society of Nephrology : JASN) |
| Journal's citation record | 3 / 4 | Journal of the American Society of Nephrology: journal h-index 370 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 593 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 39.5 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 5 / 6 | Cited 21.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 3 / 4 | Cited 144 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Ziad A. Massy: h-index 100 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Inserm: institution h-index 1,988 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23291474) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 52 / 100 | — |
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