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Cerebellar volumes’ selective association with MoCA over MMSE: a diagnostic insight into mild cognitive impairment and mild dementia
Maria Devita, Chiara Ceolin, Chiara Begliomini, Michela Sarlo, Alessandra Coin, A. Bertoldo, Giuseppe Sergi, Daniela Mapelli et al.. Neurological Sciences, 2026-01-21
Topic: Risk, prevention and care in population studies
MoCA scores showed significant positive correlations with cognitive-related cerebellar regions, particularly the left Crus I lobule (r = 0.40, p = 0.02) and total Crus I volume (r = 0.36, p = 0.04). Regression analysis confirmed associations with the left Crus I (β = 0.08, p = 0.02) and right VIIB lobule (β = 0.033, p = 0.032), while MMSE scores correlated only with right Lobule X thickness (r = -0.35, p = 0.04). These findings suggest MoCA may better detect cerebellar-related cognitive impairments, underscoring the importance of including cerebellar evaluation in the early diagnosis of dementia.
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APA 7th
Devita, M., Ceolin, C., Begliomini, C., Sarlo, M., Coin, A., Bertoldo, A., et al. (2026). Cerebellar volumes’ selective association with MoCA over MMSE: a diagnostic insight into mild cognitive impairment and mild dementia. Neurological Sciences. https://doi.org/10.1007/s10072-026-08816-9
Vancouver
Devita M, Ceolin C, Begliomini C, Sarlo M, Coin A, Bertoldo A, et al. Cerebellar volumes’ selective association with MoCA over MMSE: a diagnostic insight into mild cognitive impairment and mild dementia. Neurological Sciences. 2026. doi:10.1007/s10072-026-08816-9. PMID: 41563581.
BibTeX
@article{devita2026-41563581,
author = {Devita, Maria and Ceolin, Chiara and Begliomini, Chiara and Sarlo, Michela and Coin, Alessandra and Bertoldo, A. and Sergi, Giuseppe and Mapelli, Daniela and others},
title = {{Cerebellar volumes’ selective association with MoCA over MMSE: a diagnostic insight into mild cognitive impairment and mild dementia}},
journal = {Neurological Sciences},
year = {2026},
doi = {10.1007/s10072-026-08816-9},
pmid = {41563581},
url = {https://doi.org/10.1007/s10072-026-08816-9}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- MoCA scores showed significant positive correlations with cognitive-related cerebellar regions, particularly the left Crus I lobule (r = 0.40, p = 0.02) and total Crus I volume (r = 0.36, p = 0.04).
- Regression analysis confirmed associations with the left Crus I (β = 0.08, p = 0.02) and right VIIB lobule (β = 0.033, p = 0.032), while MMSE scores correlated only with right Lobule X thickness (r = -0.35, p = 0.04).
- These findings suggest MoCA may better detect cerebellar-related cognitive impairments, underscoring the importance of including cerebellar evaluation in the early diagnosis of dementia.
Why it matters
In this imaging study, MoCA scores correlated with certain cerebellar regions while MMSE scores correlated with only one, suggesting MoCA may better detect cerebellar-related cognitive impairment. This concerns diagnosis and brain measurement, not treatment, cure or prevention.
Study details
- Evidence strengthLow
How this study scored 32/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurological Sciences) |
| Journal's citation record | 1 / 4 | Neurological Sciences: journal h-index 113 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Marina DE RUI: h-index 29 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Padua: institution h-index 1,158 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41563581) |
| Free to read | 2 / 2 | Free to read |
| Total | 32 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1007/s10072-026-08816-9
- PubMed: 41563581
- Original source →
- Free full text: Neurological Sciences →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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